GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
GO:00313301 | Colorectum | SER | negative regulation of cellular catabolic process | 70/2897 | 262/18723 | 1.79e-06 | 7.70e-05 | 70 |
GO:00070431 | Colorectum | SER | cell-cell junction assembly | 45/2897 | 146/18723 | 2.23e-06 | 9.31e-05 | 45 |
GO:00341091 | Colorectum | SER | homotypic cell-cell adhesion | 32/2897 | 90/18723 | 2.23e-06 | 9.31e-05 | 32 |
GO:19033631 | Colorectum | SER | negative regulation of cellular protein catabolic process | 28/2897 | 75/18723 | 3.17e-06 | 1.25e-04 | 28 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:00421771 | Colorectum | SER | negative regulation of protein catabolic process | 38/2897 | 121/18723 | 8.20e-06 | 2.76e-04 | 38 |
GO:00313971 | Colorectum | SER | negative regulation of protein ubiquitination | 29/2897 | 83/18723 | 9.72e-06 | 3.22e-04 | 29 |
GO:00433931 | Colorectum | SER | regulation of protein binding | 54/2897 | 196/18723 | 1.00e-05 | 3.31e-04 | 54 |
GO:00468221 | Colorectum | SER | regulation of nucleocytoplasmic transport | 34/2897 | 106/18723 | 1.46e-05 | 4.47e-04 | 34 |
GO:00971911 | Colorectum | SER | extrinsic apoptotic signaling pathway | 58/2897 | 219/18723 | 1.76e-05 | 5.22e-04 | 58 |
GO:00066111 | Colorectum | SER | protein export from nucleus | 22/2897 | 57/18723 | 1.91e-05 | 5.58e-04 | 22 |
GO:00468241 | Colorectum | SER | positive regulation of nucleocytoplasmic transport | 23/2897 | 62/18723 | 2.64e-05 | 7.21e-04 | 23 |
GO:19022531 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 14/2897 | 29/18723 | 3.36e-05 | 8.85e-04 | 14 |
GO:19030511 | Colorectum | SER | negative regulation of proteolysis involved in cellular protein catabolic process | 23/2897 | 64/18723 | 4.75e-05 | 1.18e-03 | 23 |
GO:19033211 | Colorectum | SER | negative regulation of protein modification by small protein conjugation or removal | 30/2897 | 95/18723 | 6.29e-05 | 1.46e-03 | 30 |
GO:00510991 | Colorectum | SER | positive regulation of binding | 46/2897 | 173/18723 | 1.12e-04 | 2.34e-03 | 46 |
GO:00511681 | Colorectum | SER | nuclear export | 42/2897 | 154/18723 | 1.19e-04 | 2.46e-03 | 42 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F7 | SNV | Missense_Mutation | novel | c.308N>A | p.Ser103Tyr | p.S103Y | P08709 | protein_coding | tolerated(0.17) | benign(0.028) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F7 | SNV | Missense_Mutation | | c.729N>G | p.Ile243Met | p.I243M | P08709 | protein_coding | deleterious(0.04) | benign(0.157) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F7 | SNV | Missense_Mutation | novel | c.1132N>A | p.Gly378Arg | p.G378R | P08709 | protein_coding | tolerated(0.22) | benign(0) | TCGA-AR-A2LJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
F7 | SNV | Missense_Mutation | rs749760143 | c.973N>A | p.Glu325Lys | p.E325K | P08709 | protein_coding | tolerated(0.05) | probably_damaging(0.933) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
F7 | insertion | Frame_Shift_Ins | novel | c.731_732insGGGAAAATGGGCAGGTCAGC | p.Asn244LysfsTer28 | p.N244Kfs*28 | P08709 | protein_coding | | | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F7 | insertion | Frame_Shift_Ins | novel | c.757_758insGCAA | p.His253ArgfsTer29 | p.H253Rfs*29 | P08709 | protein_coding | | | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
F7 | insertion | In_Frame_Ins | novel | c.759_760insCCCAAGGCCGAATTGTGGGGGGCAAGG | p.His253_Cys254insProLysAlaGluLeuTrpGlyAlaArg | p.H253_C254insPKAELWGAR | P08709 | protein_coding | | | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
F7 | SNV | Missense_Mutation | | c.475N>C | p.Glu159Gln | p.E159Q | P08709 | protein_coding | deleterious(0.04) | benign(0.115) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
F7 | SNV | Missense_Mutation | novel | c.348N>C | p.Gln116His | p.Q116H | P08709 | protein_coding | deleterious(0.02) | probably_damaging(0.961) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
F7 | SNV | Missense_Mutation | | c.160N>A | p.Val54Ile | p.V54I | P08709 | protein_coding | tolerated(0.2) | benign(0.01) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | Vatreptacog alfa (activated) | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | Factor viia | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | Recombinant factor VIIa PEGylated liposomal | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | F-7TG | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | BAX-817 | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | inhibitor | 178103166 | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | CB-813 | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | Activated recombinant FVII-albumin fusion protein | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | inhibitor | 252166701 | | |
2155 | F7 | ENZYME, DRUGGABLE GENOME, PROTEASE | | Eptacog alfa intravenous | | |