Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DDIT3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DDIT3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DDIT3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/DDIT3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DDIT3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200124218 | Prostate | BPH | regulation of intrinsic apoptotic signaling pathway | 70/3107 | 164/18723 | 2.34e-15 | 3.72e-13 | 70 |
GO:005109818 | Prostate | BPH | regulation of binding | 121/3107 | 363/18723 | 2.74e-15 | 4.14e-13 | 121 |
GO:000698618 | Prostate | BPH | response to unfolded protein | 61/3107 | 137/18723 | 1.40e-14 | 1.80e-12 | 61 |
GO:003596618 | Prostate | BPH | response to topologically incorrect protein | 66/3107 | 159/18723 | 7.35e-14 | 7.98e-12 | 66 |
GO:006219718 | Prostate | BPH | cellular response to chemical stress | 110/3107 | 337/18723 | 2.44e-13 | 2.40e-11 | 110 |
GO:004316118 | Prostate | BPH | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3107 | 412/18723 | 3.84e-13 | 3.60e-11 | 127 |
GO:00160559 | Prostate | BPH | Wnt signaling pathway | 126/3107 | 444/18723 | 2.27e-10 | 1.23e-08 | 126 |
GO:01987389 | Prostate | BPH | cell-cell signaling by wnt | 126/3107 | 446/18723 | 3.11e-10 | 1.67e-08 | 126 |
GO:003462017 | Prostate | BPH | cellular response to unfolded protein | 42/3107 | 96/18723 | 3.43e-10 | 1.81e-08 | 42 |
GO:005110118 | Prostate | BPH | regulation of DNA binding | 48/3107 | 118/18723 | 4.13e-10 | 2.15e-08 | 48 |
GO:20012359 | Prostate | BPH | positive regulation of apoptotic signaling pathway | 50/3107 | 126/18723 | 5.08e-10 | 2.56e-08 | 50 |
GO:004362018 | Prostate | BPH | regulation of DNA-templated transcription in response to stress | 28/3107 | 53/18723 | 1.57e-09 | 6.70e-08 | 28 |
GO:003596718 | Prostate | BPH | cellular response to topologically incorrect protein | 46/3107 | 116/18723 | 2.54e-09 | 1.01e-07 | 46 |
GO:00301119 | Prostate | BPH | regulation of Wnt signaling pathway | 95/3107 | 328/18723 | 1.23e-08 | 3.99e-07 | 95 |
GO:003096810 | Prostate | BPH | endoplasmic reticulum unfolded protein response | 33/3107 | 74/18723 | 1.47e-08 | 4.63e-07 | 33 |
GO:004361818 | Prostate | BPH | regulation of transcription from RNA polymerase II promoter in response to stress | 24/3107 | 47/18723 | 5.48e-08 | 1.50e-06 | 24 |
GO:190589718 | Prostate | BPH | regulation of response to endoplasmic reticulum stress | 34/3107 | 82/18723 | 8.14e-08 | 2.05e-06 | 34 |
GO:00608289 | Prostate | BPH | regulation of canonical Wnt signaling pathway | 75/3107 | 253/18723 | 1.47e-07 | 3.43e-06 | 75 |
GO:007099718 | Prostate | BPH | neuron death | 98/3107 | 361/18723 | 2.35e-07 | 5.12e-06 | 98 |
GO:190121618 | Prostate | BPH | positive regulation of neuron death | 37/3107 | 97/18723 | 2.88e-07 | 6.16e-06 | 37 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501239 | Esophagus | HGIN | Parkinson disease | 124/1383 | 266/8465 | 5.95e-32 | 9.70e-30 | 7.70e-30 | 124 |
hsa0502030 | Esophagus | HGIN | Prion disease | 117/1383 | 273/8465 | 4.15e-26 | 3.38e-24 | 2.69e-24 | 117 |
hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa0502230 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
hsa0501030 | Esophagus | HGIN | Alzheimer disease | 130/1383 | 384/8465 | 5.26e-18 | 1.71e-16 | 1.36e-16 | 130 |
hsa0493230 | Esophagus | HGIN | Non-alcoholic fatty liver disease | 66/1383 | 155/8465 | 5.21e-15 | 1.21e-13 | 9.64e-14 | 66 |
hsa0414139 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa0421020 | Esophagus | HGIN | Apoptosis | 36/1383 | 136/8465 | 1.67e-03 | 1.52e-02 | 1.20e-02 | 36 |
hsa0541739 | Esophagus | HGIN | Lipid and atherosclerosis | 51/1383 | 215/8465 | 2.95e-03 | 2.41e-02 | 1.91e-02 | 51 |
hsa05012114 | Esophagus | HGIN | Parkinson disease | 124/1383 | 266/8465 | 5.95e-32 | 9.70e-30 | 7.70e-30 | 124 |
hsa05020113 | Esophagus | HGIN | Prion disease | 117/1383 | 273/8465 | 4.15e-26 | 3.38e-24 | 2.69e-24 | 117 |
hsa05014113 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa05022113 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
hsa05010113 | Esophagus | HGIN | Alzheimer disease | 130/1383 | 384/8465 | 5.26e-18 | 1.71e-16 | 1.36e-16 | 130 |
hsa04932113 | Esophagus | HGIN | Non-alcoholic fatty liver disease | 66/1383 | 155/8465 | 5.21e-15 | 1.21e-13 | 9.64e-14 | 66 |
hsa04141114 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa04210110 | Esophagus | HGIN | Apoptosis | 36/1383 | 136/8465 | 1.67e-03 | 1.52e-02 | 1.20e-02 | 36 |
hsa05417114 | Esophagus | HGIN | Lipid and atherosclerosis | 51/1383 | 215/8465 | 2.95e-03 | 2.41e-02 | 1.91e-02 | 51 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
DDIT3 | CD8TRM | Cervix | CC | AKR1A1,DNAJB1,TNFAIP6, etc. | 1.55e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
DDIT3 | CD4TN | Endometrium | EEC | SNHG12,C6orf48,SLC3A2, etc. | 9.94e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_EEC/regulons_activity_in_dotplot.png) |
DDIT3 | CD8TRM | Esophagus | ESCC | TIAF1,FAM20B,DNAJB1, etc. | 4.71e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ESCC/regulons_activity_in_dotplot.png) |
DDIT3 | TFH | Lung | MIAC | HSPE1,HSPD1,HSP90AA1, etc. | 2.26e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_MIAC/regulons_activity_in_dotplot.png) |
DDIT3 | TFC | Thyroid | Healthy | ID3,SNHG5,LIMCH1, etc. | 2.75e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | FENRETINIDE | FENRETINIDE | 12234979,17273769 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | PROTEIN SYNTHESIS INHIBITOR | | 1735464 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | TAXOL | PACLITAXEL | 8554977 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | SURAMIN | SURAMIN | 9586958 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | DICLOFENAC | DICLOFENAC | 15131590 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | PHOTOSENSITIZER | | 15611953 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | QUINONE | | 8794898 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | TAXOTERE | TAXOTERE | 10470115 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | CISPLATIN | CISPLATIN | 10071988,8554977 |
1649 | DDIT3 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR | | STAUROSPORINE | STAUROSPORINE | 17167033 |