Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CYFIP1

Gene summary for CYFIP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CYFIP1

Gene ID

23191

Gene namecytoplasmic FMR1 interacting protein 1
Gene AliasP140SRA-1
Cytomap15q11.2
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q7L576


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23191CYFIP1HTA11_347_2000001011HumanColorectumAD6.93e-095.52e-01-0.1954
23191CYFIP1HTA11_1391_2000001011HumanColorectumAD3.70e-034.81e-01-0.059
23191CYFIP1A015-C-203HumanColorectumFAP7.36e-15-2.25e-01-0.1294
23191CYFIP1A015-C-204HumanColorectumFAP1.26e-03-1.81e-01-0.0228
23191CYFIP1A014-C-040HumanColorectumFAP8.71e-04-4.37e-01-0.1184
23191CYFIP1A002-C-201HumanColorectumFAP3.76e-08-2.33e-010.0324
23191CYFIP1A001-C-119HumanColorectumFAP5.05e-03-1.38e-01-0.1557
23191CYFIP1A001-C-108HumanColorectumFAP9.25e-05-5.58e-02-0.0272
23191CYFIP1A002-C-205HumanColorectumFAP1.40e-12-1.62e-01-0.1236
23191CYFIP1A015-C-005HumanColorectumFAP2.53e-03-2.39e-01-0.0336
23191CYFIP1A015-C-006HumanColorectumFAP3.87e-08-2.54e-01-0.0994
23191CYFIP1A015-C-106HumanColorectumFAP4.19e-05-5.14e-02-0.0511
23191CYFIP1A002-C-114HumanColorectumFAP5.16e-10-6.59e-02-0.1561
23191CYFIP1A015-C-104HumanColorectumFAP5.94e-17-1.63e-01-0.1899
23191CYFIP1A001-C-014HumanColorectumFAP3.69e-08-1.74e-010.0135
23191CYFIP1A002-C-016HumanColorectumFAP2.82e-14-1.78e-010.0521
23191CYFIP1A015-C-002HumanColorectumFAP1.80e-06-1.26e-01-0.0763
23191CYFIP1A001-C-203HumanColorectumFAP5.47e-05-1.27e-01-0.0481
23191CYFIP1A002-C-116HumanColorectumFAP3.76e-20-2.66e-01-0.0452
23191CYFIP1A014-C-008HumanColorectumFAP4.63e-06-1.92e-01-0.191
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00486384LiverNAFLDregulation of developmental growth48/1882330/187235.74e-034.37e-0248
GO:00105925LiverNAFLDpositive regulation of lamellipodium assembly8/188229/187236.40e-034.69e-028
GO:00615645LiverNAFLDaxon development64/1882467/187236.48e-034.69e-0264
GO:00364653LiverNAFLDsynaptic vesicle recycling15/188275/187237.02e-034.91e-0215
GO:00308337LiverNAFLDregulation of actin filament polymerization28/1882172/187237.15e-034.96e-0228
GO:00074095LiverNAFLDaxonogenesis58/1882418/187237.16e-034.96e-0258
GO:000641712LiverCirrhoticregulation of translation194/4634468/187237.28e-168.79e-14194
GO:004325412LiverCirrhoticregulation of protein-containing complex assembly169/4634428/187237.40e-124.99e-10169
GO:000701512LiverCirrhoticactin filament organization171/4634442/187233.93e-112.30e-09171
GO:002260412LiverCirrhoticregulation of cell morphogenesis127/4634309/187231.45e-107.44e-09127
GO:190290312LiverCirrhoticregulation of supramolecular fiber organization148/4634383/187238.85e-104.08e-08148
GO:003297012LiverCirrhoticregulation of actin filament-based process152/4634397/187231.12e-095.00e-08152
GO:003295612LiverCirrhoticregulation of actin cytoskeleton organization136/4634358/187231.47e-085.49e-07136
GO:005125812LiverCirrhoticprotein polymerization116/4634297/187232.87e-089.78e-07116
GO:000836012LiverCirrhoticregulation of cell shape69/4634154/187234.21e-081.36e-0669
GO:011005312LiverCirrhoticregulation of actin filament organization108/4634278/187231.17e-073.32e-06108
GO:00313347LiverCirrhoticpositive regulation of protein-containing complex assembly95/4634237/187231.21e-073.39e-0695
GO:190290512LiverCirrhoticpositive regulation of supramolecular fiber organization86/4634209/187231.21e-073.39e-0686
GO:004343412LiverCirrhoticresponse to peptide hormone149/4634414/187231.70e-074.49e-06149
GO:007137511LiverCirrhoticcellular response to peptide hormone stimulus110/4634290/187233.73e-078.82e-06110
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa05130ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa04810ColorectumADRegulation of actin cytoskeleton75/2092229/84653.36e-031.76e-021.12e-0275
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa051301ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa048101ColorectumADRegulation of actin cytoskeleton75/2092229/84653.36e-031.76e-021.12e-0275
hsa051308ColorectumFAPPathogenic Escherichia coli infection62/1404197/84651.37e-073.08e-061.87e-0662
hsa048106ColorectumFAPRegulation of actin cytoskeleton65/1404229/84654.07e-065.91e-053.59e-0565
hsa051328ColorectumFAPSalmonella infection67/1404249/84652.04e-052.52e-041.53e-0467
hsa051309ColorectumFAPPathogenic Escherichia coli infection62/1404197/84651.37e-073.08e-061.87e-0662
hsa048107ColorectumFAPRegulation of actin cytoskeleton65/1404229/84654.07e-065.91e-053.59e-0565
hsa051329ColorectumFAPSalmonella infection67/1404249/84652.04e-052.52e-041.53e-0467
hsa0513010ColorectumCRCPathogenic Escherichia coli infection47/1091197/84651.49e-053.84e-042.60e-0447
hsa048108ColorectumCRCRegulation of actin cytoskeleton52/1091229/84652.34e-055.57e-043.78e-0452
hsa0513210ColorectumCRCSalmonella infection48/1091249/84652.43e-031.69e-021.15e-0248
hsa0513011ColorectumCRCPathogenic Escherichia coli infection47/1091197/84651.49e-053.84e-042.60e-0447
hsa048109ColorectumCRCRegulation of actin cytoskeleton52/1091229/84652.34e-055.57e-043.78e-0452
hsa0513211ColorectumCRCSalmonella infection48/1091249/84652.43e-031.69e-021.15e-0248
hsa05132211EsophagusESCCSalmonella infection191/4205249/84656.51e-195.45e-172.79e-17191
hsa05130211EsophagusESCCPathogenic Escherichia coli infection142/4205197/84658.21e-111.06e-095.42e-10142
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CYFIP1SNVMissense_Mutationrs748203521c.3367N>Ap.Glu1123Lysp.E1123KQ7L576protein_codingtolerated(0.06)benign(0.442)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
CYFIP1SNVMissense_Mutationnovelc.1339G>Ap.Glu447Lysp.E447KQ7L576protein_codingdeleterious(0)probably_damaging(0.975)TCGA-A1-A0SP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapySD
CYFIP1SNVMissense_Mutationnovelc.1986N>Cp.Glu662Aspp.E662DQ7L576protein_codingdeleterious(0.03)probably_damaging(0.998)TCGA-AN-A0AT-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
CYFIP1SNVMissense_Mutationnovelc.3055G>Ap.Val1019Metp.V1019MQ7L576protein_codingtolerated(0.08)possibly_damaging(0.873)TCGA-BH-A0BM-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
CYFIP1SNVMissense_Mutationnovelc.2717G>Tp.Arg906Leup.R906LQ7L576protein_codingtolerated(0.24)benign(0.175)TCGA-BH-A0GZ-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
CYFIP1SNVMissense_Mutationrs761297983c.29N>Tp.Ala10Valp.A10VQ7L576protein_codingdeleterious(0.01)probably_damaging(0.986)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CYFIP1SNVMissense_Mutationnovelc.506N>Tp.Ala169Valp.A169VQ7L576protein_codingdeleterious(0.03)benign(0.057)TCGA-C8-A27B-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
CYFIP1SNVMissense_Mutationnovelc.2357G>Ap.Arg786Glnp.R786QQ7L576protein_codingdeleterious(0.01)possibly_damaging(0.647)TCGA-GM-A2D9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
CYFIP1SNVMissense_Mutationnovelc.1066N>Ap.His356Asnp.H356NQ7L576protein_codingdeleterious(0.01)benign(0.056)TCGA-OL-A66P-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanCR
CYFIP1insertionNonsense_Mutationnovelc.2129_2130insCCTTCCCTGp.Ile710_Phe711insLeuProTerp.I710_F711insLP*Q7L576protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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