Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/COA1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/COA1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/COA1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/COA1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/COA1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/COA1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00097557 | Lung | IAC | hormone-mediated signaling pathway | 36/2061 | 190/18723 | 7.95e-04 | 1.02e-02 | 36 |
GO:00606695 | Lung | IAC | embryonic placenta morphogenesis | 9/2061 | 26/18723 | 1.27e-03 | 1.45e-02 | 9 |
GO:00309002 | Lung | IAC | forebrain development | 61/2061 | 379/18723 | 1.52e-03 | 1.61e-02 | 61 |
GO:00487328 | Lung | IAC | gland development | 68/2061 | 436/18723 | 1.94e-03 | 1.97e-02 | 68 |
GO:00323554 | Lung | IAC | response to estradiol | 27/2061 | 141/18723 | 2.89e-03 | 2.60e-02 | 27 |
GO:00485684 | Lung | IAC | embryonic organ development | 64/2061 | 427/18723 | 6.46e-03 | 4.59e-02 | 64 |
GO:004851112 | Lung | AIS | rhythmic process | 61/1849 | 298/18723 | 2.63e-08 | 3.40e-06 | 61 |
GO:001657012 | Lung | AIS | histone modification | 81/1849 | 463/18723 | 2.30e-07 | 2.16e-05 | 81 |
GO:003052213 | Lung | AIS | intracellular receptor signaling pathway | 53/1849 | 265/18723 | 4.57e-07 | 3.55e-05 | 53 |
GO:004854513 | Lung | AIS | response to steroid hormone | 59/1849 | 339/18723 | 1.15e-05 | 4.65e-04 | 59 |
GO:006145812 | Lung | AIS | reproductive system development | 70/1849 | 427/18723 | 1.52e-05 | 5.50e-04 | 70 |
GO:004860811 | Lung | AIS | reproductive structure development | 69/1849 | 424/18723 | 2.23e-05 | 7.42e-04 | 69 |
GO:000170112 | Lung | AIS | in utero embryonic development | 59/1849 | 367/18723 | 1.20e-04 | 2.75e-03 | 59 |
GO:003166813 | Lung | AIS | cellular response to extracellular stimulus | 41/1849 | 246/18723 | 5.90e-04 | 9.03e-03 | 41 |
GO:190165413 | Lung | AIS | response to ketone | 34/1849 | 194/18723 | 6.76e-04 | 1.01e-02 | 34 |
GO:007149613 | Lung | AIS | cellular response to external stimulus | 50/1849 | 320/18723 | 7.41e-04 | 1.07e-02 | 50 |
GO:00508788 | Lung | AIS | regulation of body fluid levels | 57/1849 | 379/18723 | 8.60e-04 | 1.17e-02 | 57 |
GO:000189212 | Lung | AIS | embryonic placenta development | 18/1849 | 82/18723 | 9.09e-04 | 1.21e-02 | 18 |
GO:000975512 | Lung | AIS | hormone-mediated signaling pathway | 33/1849 | 190/18723 | 9.44e-04 | 1.25e-02 | 33 |
GO:004873213 | Lung | AIS | gland development | 63/1849 | 436/18723 | 1.34e-03 | 1.66e-02 | 63 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COA1 | SNV | Missense_Mutation | novel | c.355G>A | p.Glu119Lys | p.E119K | Q9GZY4 | protein_coding | deleterious(0) | possibly_damaging(0.751) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COA1 | SNV | Missense_Mutation | | c.229G>A | p.Asp77Asn | p.D77N | Q9GZY4 | protein_coding | deleterious(0.03) | probably_damaging(0.91) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
COA1 | insertion | In_Frame_Ins | novel | c.340_341insAAGGAGTAGAGACGACCCAGAAGACCCAGCTTGCTTCTAGTCCAT | p.Arg114delinsLysGlyValGluThrThrGlnLysThrGlnLeuAlaSerSerProTrp | p.R114delinsKGVETTQKTQLASSPW | Q9GZY4 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
COA1 | SNV | Missense_Mutation | novel | c.247G>A | p.Asp83Asn | p.D83N | Q9GZY4 | protein_coding | deleterious(0.04) | possibly_damaging(0.833) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
COA1 | SNV | Missense_Mutation | | c.146T>C | p.Leu49Ser | p.L49S | Q9GZY4 | protein_coding | tolerated(0.11) | benign(0.079) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
COA1 | SNV | Missense_Mutation | rs140065703 | c.82N>A | p.Gly28Arg | p.G28R | Q9GZY4 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
COA1 | insertion | Frame_Shift_Ins | novel | c.365_366insT | p.Leu122PhefsTer20 | p.L122Ffs*20 | Q9GZY4 | protein_coding | | | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COA1 | SNV | Missense_Mutation | | c.229N>T | p.Asp77Tyr | p.D77Y | Q9GZY4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
COA1 | SNV | Missense_Mutation | rs751652291 | c.32N>A | p.Arg11Gln | p.R11Q | Q9GZY4 | protein_coding | tolerated(0.67) | benign(0) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COA1 | SNV | Missense_Mutation | | c.229G>A | p.Asp77Asn | p.D77N | Q9GZY4 | protein_coding | deleterious(0.03) | probably_damaging(0.91) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |