Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CCT7_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CCT7_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CCT7_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CCT7_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CCT7_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CCT7_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CCT7_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CCT7_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CCT7_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003220611 | Liver | HCC | positive regulation of telomere maintenance | 35/7958 | 52/18723 | 2.63e-04 | 1.94e-03 | 35 |
GO:007019811 | Liver | HCC | protein localization to chromosome, telomeric region | 22/7958 | 29/18723 | 2.73e-04 | 1.98e-03 | 22 |
GO:00718975 | Liver | HCC | DNA biosynthetic process | 99/7958 | 180/18723 | 4.66e-04 | 3.08e-03 | 99 |
GO:19048721 | Liver | HCC | regulation of telomerase RNA localization to Cajal body | 15/7958 | 18/18723 | 4.74e-04 | 3.12e-03 | 15 |
GO:19048741 | Liver | HCC | positive regulation of telomerase RNA localization to Cajal body | 13/7958 | 15/18723 | 5.67e-04 | 3.61e-03 | 13 |
GO:190435812 | Liver | HCC | positive regulation of telomere maintenance via telomere lengthening | 26/7958 | 37/18723 | 5.88e-04 | 3.74e-03 | 26 |
GO:007020212 | Liver | HCC | regulation of establishment of protein localization to chromosome | 11/7958 | 12/18723 | 5.97e-04 | 3.75e-03 | 11 |
GO:190340511 | Liver | HCC | protein localization to nuclear body | 11/7958 | 12/18723 | 5.97e-04 | 3.75e-03 | 11 |
GO:190481611 | Liver | HCC | positive regulation of protein localization to chromosome, telomeric region | 11/7958 | 12/18723 | 5.97e-04 | 3.75e-03 | 11 |
GO:190486711 | Liver | HCC | protein localization to Cajal body | 11/7958 | 12/18723 | 5.97e-04 | 3.75e-03 | 11 |
GO:00345021 | Liver | HCC | protein localization to chromosome | 55/7958 | 92/18723 | 6.12e-04 | 3.82e-03 | 55 |
GO:003221211 | Liver | HCC | positive regulation of telomere maintenance via telomerase | 24/7958 | 34/18723 | 8.62e-04 | 5.13e-03 | 24 |
GO:200057312 | Liver | HCC | positive regulation of DNA biosynthetic process | 41/7958 | 66/18723 | 1.02e-03 | 5.86e-03 | 41 |
GO:19048141 | Liver | HCC | regulation of protein localization to chromosome, telomeric region | 12/7958 | 14/18723 | 1.17e-03 | 6.54e-03 | 12 |
GO:007020311 | Liver | HCC | regulation of establishment of protein localization to telomere | 10/7958 | 11/18723 | 1.30e-03 | 7.01e-03 | 10 |
GO:00906701 | Liver | HCC | RNA localization to Cajal body | 15/7958 | 19/18723 | 1.36e-03 | 7.28e-03 | 15 |
GO:00906711 | Liver | HCC | telomerase RNA localization to Cajal body | 15/7958 | 19/18723 | 1.36e-03 | 7.28e-03 | 15 |
GO:00906721 | Liver | HCC | telomerase RNA localization | 15/7958 | 19/18723 | 1.36e-03 | 7.28e-03 | 15 |
GO:00906851 | Liver | HCC | RNA localization to nucleus | 15/7958 | 19/18723 | 1.36e-03 | 7.28e-03 | 15 |
GO:00322001 | Liver | HCC | telomere organization | 86/7958 | 159/18723 | 2.06e-03 | 1.04e-02 | 86 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT7 | SNV | Missense_Mutation | novel | c.938G>C | p.Arg313Pro | p.R313P | Q99832 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-A2-A3XV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CCT7 | SNV | Missense_Mutation | | c.667N>C | p.Ala223Pro | p.A223P | Q99832 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT7 | SNV | Missense_Mutation | rs541718985 | c.1339N>T | p.Arg447Cys | p.R447C | Q99832 | protein_coding | deleterious(0) | benign(0.12) | TCGA-AR-A1AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT7 | SNV | Missense_Mutation | novel | c.256N>A | p.Gln86Lys | p.Q86K | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCT7 | SNV | Missense_Mutation | novel | c.257N>T | p.Gln86Leu | p.Q86L | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCT7 | insertion | Frame_Shift_Ins | novel | c.117_118insT | p.Leu40SerfsTer21 | p.L40Sfs*21 | Q99832 | protein_coding | | | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CCT7 | insertion | Frame_Shift_Ins | novel | c.118_119insAAGCTCTTGGCATCTTGCATTT | p.Leu40GlnfsTer28 | p.L40Qfs*28 | Q99832 | protein_coding | | | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CCT7 | SNV | Missense_Mutation | novel | c.1242N>C | p.Met414Ile | p.M414I | Q99832 | protein_coding | deleterious(0.04) | possibly_damaging(0.744) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
CCT7 | SNV | Missense_Mutation | | c.779N>C | p.Val260Ala | p.V260A | Q99832 | protein_coding | tolerated(0.18) | possibly_damaging(0.672) | TCGA-F5-6811-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT7 | SNV | Missense_Mutation | novel | c.656N>T | p.Thr219Ile | p.T219I | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |