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Gene: BSG |
Gene summary for BSG |
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Gene information | Species | Human | Gene symbol | BSG | Gene ID | 682 |
Gene name | basigin (Ok blood group) | |
Gene Alias | 5F7 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P35613 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
682 | BSG | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.28e-33 | 1.30e+00 | -0.1808 |
682 | BSG | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.15e-07 | 6.01e-01 | -0.0811 |
682 | BSG | HTA11_78_2000001011 | Human | Colorectum | AD | 2.17e-03 | 5.22e-01 | -0.1088 |
682 | BSG | HTA11_347_2000001011 | Human | Colorectum | AD | 2.49e-43 | 1.14e+00 | -0.1954 |
682 | BSG | HTA11_411_2000001011 | Human | Colorectum | SER | 2.15e-08 | 1.30e+00 | -0.2602 |
682 | BSG | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.69e-04 | 8.94e-01 | -0.2196 |
682 | BSG | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.71e-23 | 1.09e+00 | -0.1207 |
682 | BSG | HTA11_83_2000001011 | Human | Colorectum | SER | 6.90e-20 | 1.19e+00 | -0.1526 |
682 | BSG | HTA11_696_2000001011 | Human | Colorectum | AD | 2.90e-28 | 9.61e-01 | -0.1464 |
682 | BSG | HTA11_866_2000001011 | Human | Colorectum | AD | 4.31e-12 | 6.39e-01 | -0.1001 |
682 | BSG | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.33e-22 | 8.52e-01 | -0.059 |
682 | BSG | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.29e-06 | 7.53e-01 | -0.1706 |
682 | BSG | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.04e-19 | 1.42e+00 | -0.2061 |
682 | BSG | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.61e-10 | 1.39e+00 | -0.1462 |
682 | BSG | HTA11_546_2000001011 | Human | Colorectum | AD | 1.64e-05 | 6.74e-01 | -0.0842 |
682 | BSG | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.00e-03 | 5.87e-01 | -0.00410000000000005 |
682 | BSG | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.65e-05 | 5.02e-01 | -0.0179 |
682 | BSG | HTA11_866_3004761011 | Human | Colorectum | AD | 1.53e-02 | 2.64e-01 | 0.096 |
682 | BSG | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.67e-04 | 7.66e-01 | 0.0446 |
682 | BSG | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.65e-05 | 6.58e-01 | 0.0528 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018939 | Thyroid | HT | maternal placenta development | 8/1272 | 35/18723 | 2.00e-03 | 1.77e-02 | 8 |
GO:19902669 | Thyroid | HT | neutrophil migration | 17/1272 | 122/18723 | 3.65e-03 | 2.75e-02 | 17 |
GO:000189025 | Thyroid | HT | placenta development | 19/1272 | 144/18723 | 4.08e-03 | 2.99e-02 | 19 |
GO:009753014 | Thyroid | HT | granulocyte migration | 19/1272 | 148/18723 | 5.50e-03 | 3.62e-02 | 19 |
GO:00466976 | Thyroid | HT | decidualization | 6/1272 | 26/18723 | 6.89e-03 | 4.20e-02 | 6 |
GO:0016032113 | Thyroid | PTC | viral process | 236/5968 | 415/18723 | 2.48e-26 | 8.24e-24 | 236 |
GO:0019058113 | Thyroid | PTC | viral life cycle | 167/5968 | 317/18723 | 8.87e-15 | 5.89e-13 | 167 |
GO:0072659112 | Thyroid | PTC | protein localization to plasma membrane | 153/5968 | 284/18723 | 9.90e-15 | 6.50e-13 | 153 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:0044403113 | Thyroid | PTC | biological process involved in symbiotic interaction | 151/5968 | 290/18723 | 5.83e-13 | 2.85e-11 | 151 |
GO:0051701113 | Thyroid | PTC | biological process involved in interaction with host | 109/5968 | 203/18723 | 8.64e-11 | 2.99e-09 | 109 |
GO:0043434113 | Thyroid | PTC | response to peptide hormone | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:0052126113 | Thyroid | PTC | movement in host environment | 91/5968 | 175/18723 | 2.41e-08 | 5.43e-07 | 91 |
GO:006156419 | Thyroid | PTC | axon development | 199/5968 | 467/18723 | 5.27e-07 | 8.53e-06 | 199 |
GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
GO:0010038112 | Thyroid | PTC | response to metal ion | 157/5968 | 373/18723 | 1.80e-05 | 1.86e-04 | 157 |
GO:0044409113 | Thyroid | PTC | entry into host | 72/5968 | 151/18723 | 3.48e-05 | 3.29e-04 | 72 |
GO:0046718112 | Thyroid | PTC | viral entry into host cell | 68/5968 | 144/18723 | 8.26e-05 | 7.00e-04 | 68 |
GO:0061458112 | Thyroid | PTC | reproductive system development | 173/5968 | 427/18723 | 8.70e-05 | 7.23e-04 | 173 |
GO:0048608111 | Thyroid | PTC | reproductive structure development | 170/5968 | 424/18723 | 1.86e-04 | 1.41e-03 | 170 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BSG | SNV | Missense_Mutation | c.620C>T | p.Pro207Leu | p.P207L | P35613 | protein_coding | tolerated(0.47) | probably_damaging(0.915) | TCGA-A1-A0SP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
BSG | SNV | Missense_Mutation | novel | c.121G>C | p.Glu41Gln | p.E41Q | P35613 | protein_coding | deleterious(0.04) | benign(0.282) | TCGA-OL-A5DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BSG | SNV | Missense_Mutation | c.688G>C | p.Glu230Gln | p.E230Q | P35613 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
BSG | SNV | Missense_Mutation | novel | c.1000G>A | p.Glu334Lys | p.E334K | P35613 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BSG | SNV | Missense_Mutation | novel | c.862G>C | p.Glu288Gln | p.E288Q | P35613 | protein_coding | tolerated(0.58) | benign(0.003) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BSG | SNV | Missense_Mutation | novel | c.8C>T | p.Ala3Val | p.A3V | P35613 | protein_coding | tolerated(0.34) | benign(0.02) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BSG | SNV | Missense_Mutation | c.238N>T | p.His80Tyr | p.H80Y | P35613 | protein_coding | tolerated(0.06) | possibly_damaging(0.686) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BSG | SNV | Missense_Mutation | rs780701101 | c.386N>A | p.Arg129His | p.R129H | P35613 | protein_coding | tolerated(0.05) | benign(0.074) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BSG | SNV | Missense_Mutation | c.968N>T | p.Ala323Val | p.A323V | P35613 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BSG | deletion | Frame_Shift_Del | c.519delN | p.Gly175AlafsTer4 | p.G175Afs*4 | P35613 | protein_coding | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
682 | BSG | DRUGGABLE GENOME, TRANSPORTER | [131I]-Metuximab injection | |||
682 | BSG | DRUGGABLE GENOME, TRANSPORTER | Gavilimomab | GAVILIMOMAB | ||
682 | BSG | DRUGGABLE GENOME, TRANSPORTER | CHEMBL2109193 | GAVILIMOMAB | ||
682 | BSG | DRUGGABLE GENOME, TRANSPORTER | antibody | 405560467 |
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