Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003295611 | Stomach | CAG with IM | regulation of actin cytoskeleton organization | 47/1050 | 358/18723 | 4.93e-08 | 3.70e-06 | 47 |
GO:190290511 | Stomach | CAG with IM | positive regulation of supramolecular fiber organization | 31/1050 | 209/18723 | 6.83e-07 | 3.55e-05 | 31 |
GO:005125811 | Stomach | CAG with IM | protein polymerization | 38/1050 | 297/18723 | 1.77e-06 | 8.13e-05 | 38 |
GO:003227111 | Stomach | CAG with IM | regulation of protein polymerization | 32/1050 | 233/18723 | 2.53e-06 | 1.07e-04 | 32 |
GO:000815411 | Stomach | CAG with IM | actin polymerization or depolymerization | 30/1050 | 218/18723 | 4.95e-06 | 1.88e-04 | 30 |
GO:003227311 | Stomach | CAG with IM | positive regulation of protein polymerization | 22/1050 | 138/18723 | 8.56e-06 | 2.96e-04 | 22 |
GO:003004111 | Stomach | CAG with IM | actin filament polymerization | 27/1050 | 191/18723 | 8.80e-06 | 2.99e-04 | 27 |
GO:000806411 | Stomach | CAG with IM | regulation of actin polymerization or depolymerization | 26/1050 | 188/18723 | 1.90e-05 | 5.75e-04 | 26 |
GO:003083211 | Stomach | CAG with IM | regulation of actin filament length | 26/1050 | 189/18723 | 2.09e-05 | 6.09e-04 | 26 |
GO:005149511 | Stomach | CAG with IM | positive regulation of cytoskeleton organization | 29/1050 | 226/18723 | 2.73e-05 | 7.70e-04 | 29 |
GO:003083311 | Stomach | CAG with IM | regulation of actin filament polymerization | 24/1050 | 172/18723 | 3.39e-05 | 9.45e-04 | 24 |
GO:003253511 | Stomach | CAG with IM | regulation of cellular component size | 41/1050 | 383/18723 | 5.55e-05 | 1.38e-03 | 41 |
GO:003083811 | Stomach | CAG with IM | positive regulation of actin filament polymerization | 16/1050 | 99/18723 | 1.19e-04 | 2.53e-03 | 16 |
GO:000701521 | Stomach | CSG | actin filament organization | 62/1034 | 442/18723 | 1.18e-11 | 2.70e-09 | 62 |
GO:004325421 | Stomach | CSG | regulation of protein-containing complex assembly | 56/1034 | 428/18723 | 1.67e-09 | 2.16e-07 | 56 |
GO:003297021 | Stomach | CSG | regulation of actin filament-based process | 53/1034 | 397/18723 | 2.26e-09 | 2.65e-07 | 53 |
GO:190290321 | Stomach | CSG | regulation of supramolecular fiber organization | 51/1034 | 383/18723 | 4.96e-09 | 5.04e-07 | 51 |
GO:003133421 | Stomach | CSG | positive regulation of protein-containing complex assembly | 37/1034 | 237/18723 | 9.86e-09 | 9.00e-07 | 37 |
GO:011005321 | Stomach | CSG | regulation of actin filament organization | 40/1034 | 278/18723 | 2.66e-08 | 2.20e-06 | 40 |
GO:003295621 | Stomach | CSG | regulation of actin cytoskeleton organization | 47/1034 | 358/18723 | 3.10e-08 | 2.49e-06 | 47 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARPC1A | SNV | Missense_Mutation | | c.322N>C | p.Glu108Gln | p.E108Q | Q92747 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ARPC1A | SNV | Missense_Mutation | | c.875N>A | p.Ser292Asn | p.S292N | Q92747 | protein_coding | tolerated(0.26) | probably_damaging(0.979) | TCGA-D8-A1XV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARPC1A | SNV | Missense_Mutation | novel | c.43N>T | p.Ala15Ser | p.A15S | Q92747 | protein_coding | tolerated(0.23) | probably_damaging(0.971) | TCGA-OL-A5RU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
ARPC1A | insertion | Nonsense_Mutation | novel | c.365_366insGTTAAATGAGTCATGGTGAATTTTGCTC | p.Cys123LeufsTer6 | p.C123Lfs*6 | Q92747 | protein_coding | | | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ARPC1A | SNV | Missense_Mutation | rs760596520 | c.682G>A | p.Val228Met | p.V228M | Q92747 | protein_coding | deleterious(0.01) | benign(0.04) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARPC1A | SNV | Missense_Mutation | rs773348651 | c.944N>A | p.Arg315His | p.R315H | Q92747 | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-C5-A7CO-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
ARPC1A | SNV | Missense_Mutation | | c.638N>G | p.Ser213Cys | p.S213C | Q92747 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A7UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC1A | SNV | Missense_Mutation | | c.313N>C | p.Ser105Pro | p.S105P | Q92747 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ARPC1A | SNV | Missense_Mutation | | c.589G>C | p.Glu197Gln | p.E197Q | Q92747 | protein_coding | deleterious(0) | benign(0.108) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARPC1A | SNV | Missense_Mutation | | c.548N>T | p.Thr183Met | p.T183M | Q92747 | protein_coding | deleterious(0.01) | possibly_damaging(0.533) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |