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Gene: AKR1B1 |
Gene summary for AKR1B1 |
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Gene information | Species | Human | Gene symbol | AKR1B1 | Gene ID | 231 |
Gene name | aldo-keto reductase family 1 member B | |
Gene Alias | ADR | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R7A8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
231 | AKR1B1 | LZE2T | Human | Esophagus | ESCC | 1.51e-02 | 1.09e+00 | 0.082 |
231 | AKR1B1 | LZE4T | Human | Esophagus | ESCC | 6.20e-11 | 7.88e-01 | 0.0811 |
231 | AKR1B1 | LZE7T | Human | Esophagus | ESCC | 1.51e-10 | 1.05e+00 | 0.0667 |
231 | AKR1B1 | LZE22T | Human | Esophagus | ESCC | 3.10e-04 | 1.26e+00 | 0.068 |
231 | AKR1B1 | LZE24T | Human | Esophagus | ESCC | 6.70e-07 | 3.99e-01 | 0.0596 |
231 | AKR1B1 | LZE6T | Human | Esophagus | ESCC | 4.25e-05 | 5.32e-01 | 0.0845 |
231 | AKR1B1 | P1T-E | Human | Esophagus | ESCC | 4.15e-04 | 7.21e-01 | 0.0875 |
231 | AKR1B1 | P2T-E | Human | Esophagus | ESCC | 5.73e-42 | 8.95e-01 | 0.1177 |
231 | AKR1B1 | P4T-E | Human | Esophagus | ESCC | 2.55e-50 | 1.54e+00 | 0.1323 |
231 | AKR1B1 | P5T-E | Human | Esophagus | ESCC | 1.40e-33 | 9.45e-01 | 0.1327 |
231 | AKR1B1 | P8T-E | Human | Esophagus | ESCC | 6.61e-14 | 4.60e-01 | 0.0889 |
231 | AKR1B1 | P9T-E | Human | Esophagus | ESCC | 1.14e-44 | 1.47e+00 | 0.1131 |
231 | AKR1B1 | P10T-E | Human | Esophagus | ESCC | 5.64e-45 | 9.44e-01 | 0.116 |
231 | AKR1B1 | P11T-E | Human | Esophagus | ESCC | 1.02e-13 | 7.17e-01 | 0.1426 |
231 | AKR1B1 | P12T-E | Human | Esophagus | ESCC | 2.64e-59 | 1.44e+00 | 0.1122 |
231 | AKR1B1 | P15T-E | Human | Esophagus | ESCC | 1.99e-29 | 1.16e+00 | 0.1149 |
231 | AKR1B1 | P16T-E | Human | Esophagus | ESCC | 4.41e-36 | 7.11e-01 | 0.1153 |
231 | AKR1B1 | P17T-E | Human | Esophagus | ESCC | 2.89e-07 | 4.68e-01 | 0.1278 |
231 | AKR1B1 | P19T-E | Human | Esophagus | ESCC | 4.77e-12 | 1.40e+00 | 0.1662 |
231 | AKR1B1 | P20T-E | Human | Esophagus | ESCC | 3.62e-12 | 5.33e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007147015 | Thyroid | ATC | cellular response to osmotic stress | 23/6293 | 41/18723 | 2.53e-03 | 1.16e-02 | 23 |
GO:004866016 | Thyroid | ATC | regulation of smooth muscle cell proliferation | 78/6293 | 180/18723 | 4.00e-03 | 1.73e-02 | 78 |
GO:000756517 | Thyroid | ATC | female pregnancy | 82/6293 | 193/18723 | 6.04e-03 | 2.42e-02 | 82 |
GO:004636411 | Thyroid | ATC | monosaccharide biosynthetic process | 39/6293 | 82/18723 | 6.04e-03 | 2.42e-02 | 39 |
GO:00069721 | Thyroid | ATC | hyperosmotic response | 16/6293 | 28/18723 | 8.86e-03 | 3.36e-02 | 16 |
GO:009706621 | Thyroid | ATC | response to thyroid hormone | 15/6293 | 26/18723 | 9.95e-03 | 3.63e-02 | 15 |
GO:0050878112 | Thyroid | ATC | regulation of body fluid levels | 149/6293 | 379/18723 | 1.08e-02 | 3.90e-02 | 149 |
GO:00601358 | Thyroid | ATC | maternal process involved in female pregnancy | 30/6293 | 62/18723 | 1.12e-02 | 4.00e-02 | 30 |
GO:00016565 | Thyroid | ATC | metanephros development | 39/6293 | 85/18723 | 1.24e-02 | 4.38e-02 | 39 |
GO:00193194 | Thyroid | ATC | hexose biosynthetic process | 36/6293 | 78/18723 | 1.43e-02 | 4.92e-02 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKR1B1 | SNV | Missense_Mutation | novel | c.551A>T | p.Gln184Leu | p.Q184L | P15121 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
AKR1B1 | SNV | Missense_Mutation | rs770727307 | c.874T>C | p.Tyr292His | p.Y292H | P15121 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AKR1B1 | SNV | Missense_Mutation | c.591N>G | p.Ile197Met | p.I197M | P15121 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
AKR1B1 | SNV | Missense_Mutation | c.806N>A | p.Arg269His | p.R269H | P15121 | protein_coding | tolerated(0.18) | benign(0.014) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AKR1B1 | SNV | Missense_Mutation | novel | c.781A>T | p.Ile261Phe | p.I261F | P15121 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AKR1B1 | SNV | Missense_Mutation | novel | c.858N>T | p.Met286Ile | p.M286I | P15121 | protein_coding | tolerated(0.15) | possibly_damaging(0.476) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
AKR1B1 | SNV | Missense_Mutation | c.122N>A | p.Arg41His | p.R41H | P15121 | protein_coding | tolerated(0.1) | benign(0.014) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AKR1B1 | SNV | Missense_Mutation | rs755184764 | c.899N>T | p.Ala300Val | p.A300V | P15121 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AKR1B1 | SNV | Missense_Mutation | rs577826776 | c.29G>A | p.Gly10Asp | p.G10D | P15121 | protein_coding | deleterious(0.02) | benign(0.278) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AKR1B1 | SNV | Missense_Mutation | novel | c.816G>T | p.Glu272Asp | p.E272D | P15121 | protein_coding | deleterious(0.02) | benign(0.029) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | Ovine corticotropin-releasing hormone | |||
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | QR-333 | |||
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103983 | LIDORESTAT | |
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | Sulindac | SULINDAC | ||
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103990 | ZENARESTAT | |
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | Epalrestat | EPALRESTAT | ||
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | T2c-003 | |||
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | GROWTH AGENTS | 9371720 | ||
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | inhibitor | 178103991 | ZOPOLRESTAT | |
231 | AKR1B1 | DRUGGABLE GENOME, ENZYME | Oxilofrine | OXILOFRINE |
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