Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CTNNB1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CTNNB1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CTNNB1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CTNNB1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CTNNB1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CTNNB1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CTNNB1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CTNNB1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CTNNB1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CTNNB1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CTNNB1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CTNNB1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00031585 | Stomach | GC | endothelium development | 19/1159 | 136/18723 | 7.19e-04 | 9.47e-03 | 19 |
GO:00435256 | Stomach | GC | positive regulation of neuron apoptotic process | 11/1159 | 58/18723 | 7.54e-04 | 9.71e-03 | 11 |
GO:00511016 | Stomach | GC | regulation of DNA binding | 17/1159 | 118/18723 | 9.47e-04 | 1.14e-02 | 17 |
GO:19028826 | Stomach | GC | regulation of response to oxidative stress | 15/1159 | 98/18723 | 9.86e-04 | 1.18e-02 | 15 |
GO:1902105 | Stomach | GC | regulation of leukocyte differentiation | 31/1159 | 279/18723 | 1.17e-03 | 1.34e-02 | 31 |
GO:0070663 | Stomach | GC | regulation of leukocyte proliferation | 28/1159 | 245/18723 | 1.29e-03 | 1.45e-02 | 28 |
GO:00072493 | Stomach | GC | I-kappaB kinase/NF-kappaB signaling | 31/1159 | 281/18723 | 1.31e-03 | 1.46e-02 | 31 |
GO:19032026 | Stomach | GC | negative regulation of oxidative stress-induced cell death | 10/1159 | 53/18723 | 1.35e-03 | 1.49e-02 | 10 |
GO:00300996 | Stomach | GC | myeloid cell differentiation | 39/1159 | 381/18723 | 1.42e-03 | 1.55e-02 | 39 |
GO:00506784 | Stomach | GC | regulation of epithelial cell proliferation | 39/1159 | 381/18723 | 1.42e-03 | 1.55e-02 | 39 |
GO:1902106 | Stomach | GC | negative regulation of leukocyte differentiation | 15/1159 | 102/18723 | 1.49e-03 | 1.62e-02 | 15 |
GO:00343295 | Stomach | GC | cell junction assembly | 42/1159 | 420/18723 | 1.50e-03 | 1.62e-02 | 42 |
GO:0042129 | Stomach | GC | regulation of T cell proliferation | 21/1159 | 171/18723 | 2.08e-03 | 2.09e-02 | 21 |
GO:00433885 | Stomach | GC | positive regulation of DNA binding | 10/1159 | 56/18723 | 2.08e-03 | 2.09e-02 | 10 |
GO:00519726 | Stomach | GC | regulation of telomerase activity | 9/1159 | 47/18723 | 2.08e-03 | 2.09e-02 | 9 |
GO:00973055 | Stomach | GC | response to alcohol | 28/1159 | 253/18723 | 2.09e-03 | 2.09e-02 | 28 |
GO:1903707 | Stomach | GC | negative regulation of hemopoiesis | 15/1159 | 106/18723 | 2.21e-03 | 2.18e-02 | 15 |
GO:20002786 | Stomach | GC | regulation of DNA biosynthetic process | 15/1159 | 106/18723 | 2.21e-03 | 2.18e-02 | 15 |
GO:00510996 | Stomach | GC | positive regulation of binding | 21/1159 | 173/18723 | 2.40e-03 | 2.30e-02 | 21 |
GO:00454464 | Stomach | GC | endothelial cell differentiation | 16/1159 | 118/18723 | 2.50e-03 | 2.36e-02 | 16 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0516718 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0541818 | Breast | Precancer | Fluid shear stress and atherosclerosis | 28/684 | 139/8465 | 4.74e-06 | 6.00e-05 | 4.59e-05 | 28 |
hsa0510018 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0467018 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
hsa0520514 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0516316 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0516719 | Breast | Precancer | Kaposi sarcoma-associated herpesvirus infection | 36/684 | 194/8465 | 1.68e-06 | 2.53e-05 | 1.94e-05 | 36 |
hsa0541819 | Breast | Precancer | Fluid shear stress and atherosclerosis | 28/684 | 139/8465 | 4.74e-06 | 6.00e-05 | 4.59e-05 | 28 |
hsa0510019 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0467019 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
hsa0520515 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0452019 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0516317 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
CTNNB1 | NK | Endometrium | ADJ | GALNT2,PLEKHA5,SEC14L1, etc. | 4.03e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
CTNNB1 | GDT | Endometrium | AEH | GALNT2,PLEKHA5,SEC14L1, etc. | 2.12e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
CTNNB1 | NK | Endometrium | AEH | GALNT2,PLEKHA5,SEC14L1, etc. | 1.16e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
CTNNB1 | GDT | Endometrium | EEC | GALNT2,PLEKHA5,SEC14L1, etc. | 1.23e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_EEC/regulons_activity_in_dotplot.png) |
CTNNB1 | NK | Endometrium | EEC | GALNT2,PLEKHA5,SEC14L1, etc. | 5.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_EEC/regulons_activity_in_dotplot.png) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | NVP-TNKS656 | | 26224873 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | BC21 | | 22224445 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | Triciribine | TRICIRIBINE | 26224873 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | CEQ508 | | |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | dexamethasone | DEXAMETHASONE | 26521987 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | ANTI-PD-L1 MONOCLONAL ANTIBODY | | 25970248 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | EOSIN_Y | EOSIN_Y | 22889313 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | (+/-)-HYDNOCARPIN | CHEMBL91638 | 24018191 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | ANTI-CTLA-4 MONOCLONAL ANTIBODY | | 25970248 |
1499 | CTNNB1 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR COMPLEX, DRUGGABLE GENOME, DRUG RESISTANCE | | FLUORESCEIN SODIUM | FLUORESCEIN SODIUM | 22889313 |