Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ZFAND2A_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZFAND2A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/ZFAND2A_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZFAND2A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ZFAND2A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ZFAND2A_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ZFAND2A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ZFAND2A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200005841 | Stomach | WIM | regulation of ubiquitin-dependent protein catabolic process | 11/426 | 164/18723 | 1.36e-03 | 1.86e-02 | 11 |
GO:007097211 | Stomach | WIM | protein localization to endoplasmic reticulum | 7/426 | 74/18723 | 1.46e-03 | 1.97e-02 | 7 |
GO:004573241 | Stomach | WIM | positive regulation of protein catabolic process | 13/426 | 231/18723 | 2.53e-03 | 2.92e-02 | 13 |
GO:00450471 | Stomach | WIM | protein targeting to ER | 5/426 | 42/18723 | 2.53e-03 | 2.92e-02 | 5 |
GO:190336441 | Stomach | WIM | positive regulation of cellular protein catabolic process | 10/426 | 155/18723 | 2.94e-03 | 3.16e-02 | 10 |
GO:003243441 | Stomach | WIM | regulation of proteasomal ubiquitin-dependent protein catabolic process | 9/426 | 134/18723 | 3.59e-03 | 3.60e-02 | 9 |
GO:00725991 | Stomach | WIM | establishment of protein localization to endoplasmic reticulum | 5/426 | 46/18723 | 3.79e-03 | 3.71e-02 | 5 |
GO:003133141 | Stomach | WIM | positive regulation of cellular catabolic process | 19/426 | 427/18723 | 4.39e-03 | 4.12e-02 | 19 |
GO:000989641 | Stomach | WIM | positive regulation of catabolic process | 21/426 | 492/18723 | 4.55e-03 | 4.16e-02 | 21 |
GO:007259451 | Stomach | SIM | establishment of protein localization to organelle | 35/708 | 422/18723 | 1.25e-05 | 4.36e-04 | 35 |
GO:004586251 | Stomach | SIM | positive regulation of proteolysis | 32/708 | 372/18723 | 1.41e-05 | 4.83e-04 | 32 |
GO:000660551 | Stomach | SIM | protein targeting | 27/708 | 314/18723 | 6.56e-05 | 1.70e-03 | 27 |
GO:190336251 | Stomach | SIM | regulation of cellular protein catabolic process | 23/708 | 255/18723 | 1.10e-04 | 2.63e-03 | 23 |
GO:004217651 | Stomach | SIM | regulation of protein catabolic process | 30/708 | 391/18723 | 2.06e-04 | 4.26e-03 | 30 |
GO:00450472 | Stomach | SIM | protein targeting to ER | 7/708 | 42/18723 | 9.13e-04 | 1.24e-02 | 7 |
GO:200005851 | Stomach | SIM | regulation of ubiquitin-dependent protein catabolic process | 15/708 | 164/18723 | 1.43e-03 | 1.73e-02 | 15 |
GO:00725992 | Stomach | SIM | establishment of protein localization to endoplasmic reticulum | 7/708 | 46/18723 | 1.59e-03 | 1.85e-02 | 7 |
GO:003243451 | Stomach | SIM | regulation of proteasomal ubiquitin-dependent protein catabolic process | 13/708 | 134/18723 | 1.72e-03 | 1.97e-02 | 13 |
GO:007097221 | Stomach | SIM | protein localization to endoplasmic reticulum | 9/708 | 74/18723 | 1.85e-03 | 2.06e-02 | 9 |
GO:190305051 | Stomach | SIM | regulation of proteolysis involved in cellular protein catabolic process | 18/708 | 221/18723 | 1.91e-03 | 2.12e-02 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFAND2A | SNV | Missense_Mutation | novel | c.157N>T | p.His53Tyr | p.H53Y | Q8N6M9 | protein_coding | deleterious(0.02) | benign(0) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
ZFAND2A | SNV | Missense_Mutation | | c.283N>T | p.Ile95Phe | p.I95F | Q8N6M9 | protein_coding | deleterious(0) | possibly_damaging(0.643) | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZFAND2A | SNV | Missense_Mutation | novel | c.196G>T | p.Val66Leu | p.V66L | Q8N6M9 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFAND2A | SNV | Missense_Mutation | novel | c.196N>T | p.Val66Leu | p.V66L | Q8N6M9 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFAND2A | SNV | Missense_Mutation | novel | c.413G>A | p.Ser138Asn | p.S138N | Q8N6M9 | protein_coding | tolerated(0.08) | benign(0.013) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFAND2A | SNV | Missense_Mutation | novel | c.26N>G | p.His9Arg | p.H9R | Q8N6M9 | protein_coding | deleterious(0.02) | possibly_damaging(0.703) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZFAND2A | SNV | Missense_Mutation | | c.91G>T | p.Asp31Tyr | p.D31Y | Q8N6M9 | protein_coding | deleterious(0.02) | possibly_damaging(0.454) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ZFAND2A | SNV | Missense_Mutation | novel | c.380G>T | p.Arg127Ile | p.R127I | Q8N6M9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZFAND2A | SNV | Missense_Mutation | rs748607914 | c.295N>T | p.Arg99Cys | p.R99C | Q8N6M9 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZFAND2A | insertion | Frame_Shift_Ins | novel | c.129_130insCCAATCAGGAAGGCAGTAAATACGCTTATTGATTTGAATAACTGCA | p.Cys44ProfsTer33 | p.C44Pfs*33 | Q8N6M9 | protein_coding | | | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |