Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/WWOX_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/WWOX_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/WWOX_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/WWOX_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/WWOX_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/WWOX_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/WWOX_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/WWOX_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/WWOX_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/WWOX_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/WWOX_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/WWOX_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007156010 | Skin | AK | cellular response to transforming growth factor beta stimulus | 50/1910 | 250/18723 | 2.45e-06 | 6.76e-05 | 50 |
GO:200123818 | Skin | AK | positive regulation of extrinsic apoptotic signaling pathway | 15/1910 | 48/18723 | 5.33e-05 | 8.20e-04 | 15 |
GO:00301789 | Skin | AK | negative regulation of Wnt signaling pathway | 33/1910 | 170/18723 | 2.14e-04 | 2.39e-03 | 33 |
GO:2001233112 | Skin | SCCIS | regulation of apoptotic signaling pathway | 51/919 | 356/18723 | 5.51e-12 | 7.43e-09 | 51 |
GO:0097193112 | Skin | SCCIS | intrinsic apoptotic signaling pathway | 42/919 | 288/18723 | 2.40e-10 | 2.12e-07 | 42 |
GO:0001649110 | Skin | SCCIS | osteoblast differentiation | 34/919 | 229/18723 | 7.78e-09 | 2.95e-06 | 34 |
GO:001605519 | Skin | SCCIS | Wnt signaling pathway | 51/919 | 444/18723 | 1.48e-08 | 4.37e-06 | 51 |
GO:019873819 | Skin | SCCIS | cell-cell signaling by wnt | 51/919 | 446/18723 | 1.72e-08 | 4.81e-06 | 51 |
GO:003011119 | Skin | SCCIS | regulation of Wnt signaling pathway | 41/919 | 328/18723 | 3.79e-08 | 7.72e-06 | 41 |
GO:000150319 | Skin | SCCIS | ossification | 47/919 | 408/18723 | 5.02e-08 | 8.19e-06 | 47 |
GO:2001236112 | Skin | SCCIS | regulation of extrinsic apoptotic signaling pathway | 24/919 | 151/18723 | 3.42e-07 | 3.03e-05 | 24 |
GO:2001235111 | Skin | SCCIS | positive regulation of apoptotic signaling pathway | 20/919 | 126/18723 | 3.27e-06 | 1.53e-04 | 20 |
GO:200123819 | Skin | SCCIS | positive regulation of extrinsic apoptotic signaling pathway | 11/919 | 48/18723 | 1.59e-05 | 4.98e-04 | 11 |
GO:0072331112 | Skin | SCCIS | signal transduction by p53 class mediator | 22/919 | 163/18723 | 1.60e-05 | 4.98e-04 | 22 |
GO:0097191112 | Skin | SCCIS | extrinsic apoptotic signaling pathway | 26/919 | 219/18723 | 2.87e-05 | 7.82e-04 | 26 |
GO:003017814 | Skin | SCCIS | negative regulation of Wnt signaling pathway | 20/919 | 170/18723 | 2.62e-04 | 4.71e-03 | 20 |
GO:0072332112 | Skin | SCCIS | intrinsic apoptotic signaling pathway by p53 class mediator | 11/919 | 76/18723 | 1.16e-03 | 1.38e-02 | 11 |
GO:007156017 | Skin | SCCIS | cellular response to transforming growth factor beta stimulus | 22/919 | 250/18723 | 6.00e-03 | 4.61e-02 | 22 |
GO:009719329 | Skin | cSCC | intrinsic apoptotic signaling pathway | 150/4864 | 288/18723 | 1.76e-21 | 3.34e-19 | 150 |
GO:200123329 | Skin | cSCC | regulation of apoptotic signaling pathway | 173/4864 | 356/18723 | 2.25e-20 | 3.44e-18 | 173 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WWOX | SNV | Missense_Mutation | novel | c.863N>T | p.Trp288Leu | p.W288L | Q9NZC7 | protein_coding | tolerated(0.18) | benign(0.112) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WWOX | SNV | Missense_Mutation | | c.947T>C | p.Val316Ala | p.V316A | Q9NZC7 | protein_coding | deleterious(0) | possibly_damaging(0.64) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
WWOX | insertion | In_Frame_Ins | novel | c.1054_1055insTATTATCTT | p.Met352delinsIleLeuSerLeu | p.M352delinsILSL | Q9NZC7 | protein_coding | | | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WWOX | insertion | Frame_Shift_Ins | novel | c.1056_1056+1insAACTTCCTGTTGAAGGTTTTGAAAAATATAT | p.Gln353AsnfsTer186 | p.Q353Nfs*186 | Q9NZC7 | protein_coding | | | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WWOX | SNV | Missense_Mutation | | c.812C>G | p.Ser271Cys | p.S271C | Q9NZC7 | protein_coding | deleterious(0.01) | benign(0.285) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
WWOX | SNV | Missense_Mutation | | c.978N>A | p.Met326Ile | p.M326I | Q9NZC7 | protein_coding | deleterious(0.01) | possibly_damaging(0.718) | TCGA-Q1-A6DT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
WWOX | SNV | Missense_Mutation | | c.944N>A | p.Gly315Glu | p.G315E | Q9NZC7 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WWOX | SNV | Missense_Mutation | | c.497N>T | p.Ser166Leu | p.S166L | Q9NZC7 | protein_coding | tolerated(0.29) | benign(0.011) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
WWOX | SNV | Missense_Mutation | rs200815431 | c.1196N>T | p.Ala399Val | p.A399V | Q9NZC7 | protein_coding | tolerated(0.23) | benign(0.014) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WWOX | SNV | Missense_Mutation | rs764089824 | c.415N>A | p.Glu139Lys | p.E139K | Q9NZC7 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |