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Gene: UBAC2 |
Gene summary for UBAC2 |
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Gene information | Species | Human | Gene symbol | UBAC2 | Gene ID | 337867 |
Gene name | UBA domain containing 2 | |
Gene Alias | PHGDHL1 | |
Cytomap | 13q32.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A024RE02 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
337867 | UBAC2 | CCI_1 | Human | Cervix | CC | 4.37e-03 | 7.45e-01 | 0.528 |
337867 | UBAC2 | CCI_2 | Human | Cervix | CC | 1.36e-10 | 1.06e+00 | 0.5249 |
337867 | UBAC2 | CCI_3 | Human | Cervix | CC | 7.39e-12 | 9.27e-01 | 0.516 |
337867 | UBAC2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.14e-25 | -6.82e-01 | 0.0155 |
337867 | UBAC2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.18e-04 | -5.13e-01 | -0.1207 |
337867 | UBAC2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.53e-04 | -3.61e-01 | -0.1526 |
337867 | UBAC2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.13e-02 | -4.85e-01 | -0.0179 |
337867 | UBAC2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.12e-05 | -4.29e-01 | 0.096 |
337867 | UBAC2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.75e-05 | -4.87e-01 | 0.0528 |
337867 | UBAC2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.10e-03 | -4.08e-01 | 0.0338 |
337867 | UBAC2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.13e-11 | -4.40e-01 | 0.0674 |
337867 | UBAC2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.96e-11 | -4.36e-01 | 0.294 |
337867 | UBAC2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.82e-06 | 6.38e-01 | 0.281 |
337867 | UBAC2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.65e-09 | -3.88e-01 | 0.3005 |
337867 | UBAC2 | F007 | Human | Colorectum | FAP | 1.70e-02 | -3.10e-01 | 0.1176 |
337867 | UBAC2 | A001-C-207 | Human | Colorectum | FAP | 9.65e-05 | -3.23e-01 | 0.1278 |
337867 | UBAC2 | A015-C-203 | Human | Colorectum | FAP | 1.01e-44 | -7.77e-01 | -0.1294 |
337867 | UBAC2 | A015-C-204 | Human | Colorectum | FAP | 1.68e-12 | -5.07e-01 | -0.0228 |
337867 | UBAC2 | A014-C-040 | Human | Colorectum | FAP | 2.39e-08 | -6.89e-01 | -0.1184 |
337867 | UBAC2 | A002-C-201 | Human | Colorectum | FAP | 1.69e-21 | -5.67e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190382816 | Thyroid | ATC | negative regulation of cellular protein localization | 67/6293 | 117/18723 | 1.23e-07 | 2.06e-06 | 67 |
GO:003097015 | Thyroid | ATC | retrograde protein transport, ER to cytosol | 23/6293 | 29/18723 | 5.84e-07 | 8.19e-06 | 23 |
GO:190351315 | Thyroid | ATC | endoplasmic reticulum to cytosol transport | 23/6293 | 29/18723 | 5.84e-07 | 8.19e-06 | 23 |
GO:003252715 | Thyroid | ATC | protein exit from endoplasmic reticulum | 32/6293 | 48/18723 | 2.88e-06 | 3.30e-05 | 32 |
GO:003017815 | Thyroid | ATC | negative regulation of Wnt signaling pathway | 85/6293 | 170/18723 | 6.94e-06 | 7.16e-05 | 85 |
GO:009031712 | Thyroid | ATC | negative regulation of intracellular protein transport | 26/6293 | 42/18723 | 1.60e-04 | 1.10e-03 | 26 |
GO:003238713 | Thyroid | ATC | negative regulation of intracellular transport | 33/6293 | 58/18723 | 2.25e-04 | 1.46e-03 | 33 |
GO:009009014 | Thyroid | ATC | negative regulation of canonical Wnt signaling pathway | 66/6293 | 137/18723 | 2.82e-04 | 1.80e-03 | 66 |
GO:190495013 | Thyroid | ATC | negative regulation of establishment of protein localization | 61/6293 | 131/18723 | 1.38e-03 | 7.16e-03 | 61 |
GO:007086113 | Thyroid | ATC | regulation of protein exit from endoplasmic reticulum | 17/6293 | 27/18723 | 1.70e-03 | 8.47e-03 | 17 |
GO:005122413 | Thyroid | ATC | negative regulation of protein transport | 59/6293 | 127/18723 | 1.75e-03 | 8.71e-03 | 59 |
GO:190415212 | Thyroid | ATC | regulation of retrograde protein transport, ER to cytosol | 10/6293 | 14/18723 | 4.31e-03 | 1.80e-02 | 10 |
GO:005105114 | Thyroid | ATC | negative regulation of transport | 183/6293 | 470/18723 | 8.12e-03 | 3.13e-02 | 183 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBAC2 | SNV | Missense_Mutation | novel | c.378N>C | p.Leu126Phe | p.L126F | Q8NBM4 | protein_coding | tolerated(0.13) | benign(0.158) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
UBAC2 | SNV | Missense_Mutation | c.109N>C | p.Cys37Arg | p.C37R | Q8NBM4 | protein_coding | tolerated(0.21) | benign(0.1) | TCGA-B6-A1KN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
UBAC2 | SNV | Missense_Mutation | rs150911743 | c.877N>A | p.Gly293Ser | p.G293S | Q8NBM4 | protein_coding | tolerated(0.67) | benign(0.028) | TCGA-EW-A1J6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
UBAC2 | insertion | Frame_Shift_Ins | novel | c.151_152insCATATGT | p.Asp51AlafsTer18 | p.D51Afs*18 | Q8NBM4 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
UBAC2 | insertion | In_Frame_Ins | novel | c.153_154insTCCCAAAATGTGTTCCCTAATATGTATCAA | p.Asp51_Phe52insSerGlnAsnValPheProAsnMetTyrGln | p.D51_F52insSQNVFPNMYQ | Q8NBM4 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
UBAC2 | SNV | Missense_Mutation | rs775996860 | c.854G>A | p.Arg285Gln | p.R285Q | Q8NBM4 | protein_coding | tolerated(0.11) | probably_damaging(0.976) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBAC2 | SNV | Missense_Mutation | rs765235078 | c.862N>A | p.Val288Ile | p.V288I | Q8NBM4 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBAC2 | SNV | Missense_Mutation | rs550310299 | c.38N>T | p.Ala13Val | p.A13V | Q8NBM4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-DM-A0XD-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
UBAC2 | SNV | Missense_Mutation | novel | c.182G>T | p.Arg61Ile | p.R61I | Q8NBM4 | protein_coding | deleterious(0) | possibly_damaging(0.648) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBAC2 | SNV | Missense_Mutation | novel | c.505N>A | p.Gly169Arg | p.G169R | Q8NBM4 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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