GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069371 | Colorectum | FAP | regulation of muscle contraction | 37/2622 | 169/18723 | 3.39e-03 | 2.47e-02 | 37 |
GO:00970622 | Colorectum | FAP | dendritic spine maintenance | 8/2622 | 21/18723 | 5.43e-03 | 3.53e-02 | 8 |
GO:0098885 | Colorectum | FAP | modification of postsynaptic actin cytoskeleton | 5/2622 | 10/18723 | 7.32e-03 | 4.38e-02 | 5 |
GO:00070155 | Colorectum | CRC | actin filament organization | 104/2078 | 442/18723 | 4.75e-14 | 7.12e-11 | 104 |
GO:00329705 | Colorectum | CRC | regulation of actin filament-based process | 89/2078 | 397/18723 | 5.25e-11 | 3.14e-08 | 89 |
GO:00315894 | Colorectum | CRC | cell-substrate adhesion | 78/2078 | 363/18723 | 6.22e-09 | 1.49e-06 | 78 |
GO:00432545 | Colorectum | CRC | regulation of protein-containing complex assembly | 87/2078 | 428/18723 | 1.38e-08 | 2.67e-06 | 87 |
GO:00160494 | Colorectum | CRC | cell growth | 95/2078 | 482/18723 | 1.51e-08 | 2.75e-06 | 95 |
GO:19029035 | Colorectum | CRC | regulation of supramolecular fiber organization | 80/2078 | 383/18723 | 1.52e-08 | 2.75e-06 | 80 |
GO:00329565 | Colorectum | CRC | regulation of actin cytoskeleton organization | 76/2078 | 358/18723 | 1.68e-08 | 2.79e-06 | 76 |
GO:01100535 | Colorectum | CRC | regulation of actin filament organization | 63/2078 | 278/18723 | 2.21e-08 | 3.23e-06 | 63 |
GO:00325354 | Colorectum | CRC | regulation of cellular component size | 79/2078 | 383/18723 | 3.30e-08 | 4.60e-06 | 79 |
GO:00322715 | Colorectum | CRC | regulation of protein polymerization | 55/2078 | 233/18723 | 3.97e-08 | 5.28e-06 | 55 |
GO:00343294 | Colorectum | CRC | cell junction assembly | 83/2078 | 420/18723 | 1.08e-07 | 1.29e-05 | 83 |
GO:00512585 | Colorectum | CRC | protein polymerization | 64/2078 | 297/18723 | 1.26e-07 | 1.45e-05 | 64 |
GO:00081545 | Colorectum | CRC | actin polymerization or depolymerization | 51/2078 | 218/18723 | 1.65e-07 | 1.72e-05 | 51 |
GO:00070444 | Colorectum | CRC | cell-substrate junction assembly | 29/2078 | 95/18723 | 2.34e-07 | 2.27e-05 | 29 |
GO:00975815 | Colorectum | CRC | lamellipodium organization | 28/2078 | 90/18723 | 2.43e-07 | 2.27e-05 | 28 |
GO:01501154 | Colorectum | CRC | cell-substrate junction organization | 30/2078 | 101/18723 | 2.85e-07 | 2.54e-05 | 30 |
GO:00605603 | Colorectum | CRC | developmental growth involved in morphogenesis | 53/2078 | 234/18723 | 2.88e-07 | 2.54e-05 | 53 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTN | SNV | Missense_Mutation | rs557526069 | c.35041G>A | p.Glu11681Lys | p.E11681K | | protein_coding | | | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
TTN | SNV | Missense_Mutation | novel | c.31372N>C | p.Val10458Leu | p.V10458L | | protein_coding | | | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TTN | SNV | Missense_Mutation | | c.69142N>A | p.Glu23048Lys | p.E23048K | | protein_coding | | | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TTN | SNV | Missense_Mutation | novel | c.105331G>C | p.Glu35111Gln | p.E35111Q | | protein_coding | | | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TTN | SNV | Missense_Mutation | novel | c.91713G>A | p.Met30571Ile | p.M30571I | | protein_coding | | | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TTN | SNV | Missense_Mutation | | c.31520A>T | p.Glu10507Val | p.E10507V | | protein_coding | | | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | | SD |
TTN | SNV | Missense_Mutation | novel | c.43021N>A | p.Glu14341Lys | p.E14341K | | protein_coding | | | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
TTN | SNV | Missense_Mutation | | c.58960N>T | p.Val19654Phe | p.V19654F | | protein_coding | | | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
TTN | SNV | Missense_Mutation | novel | c.38183N>T | p.Lys12728Ile | p.K12728I | | protein_coding | | | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
TTN | SNV | Missense_Mutation | novel | c.10739C>G | p.Ala3580Gly | p.A3580G | | protein_coding | | | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |