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Gene: TTN |
Gene summary for TTN |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TTN | Gene ID | 7273 |
| Gene name | titin | |
| Gene Alias | CMD1G | |
| Cytomap | 2q31.2 | |
| Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q8WZ42 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7273 | TTN | HCC1_Meng | Human | Liver | HCC | 1.93e-02 | -1.44e-01 | 0.0246 |
| 7273 | TTN | HCC5 | Human | Liver | HCC | 6.34e-15 | 2.72e+00 | 0.4932 |
| 7273 | TTN | S028 | Human | Liver | HCC | 7.08e-10 | 6.89e-01 | 0.2503 |
| 7273 | TTN | S029 | Human | Liver | HCC | 1.04e-02 | 3.61e-01 | 0.2581 |
| 7273 | TTN | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.80e-10 | 5.59e-01 | -0.2116 |
| 7273 | TTN | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.21e-06 | 7.26e-01 | -0.1941 |
| 7273 | TTN | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.26e-07 | 6.77e-01 | -0.2107 |
| 7273 | TTN | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.27e-10 | 6.99e-01 | -0.2119 |
| 7273 | TTN | HTA12-18-3 | Human | Pancreas | PDAC | 1.07e-02 | 5.78e-01 | 0.0716 |
| 7273 | TTN | HTA12-25-1 | Human | Pancreas | PDAC | 2.02e-02 | 4.06e-01 | 0.313 |
| 7273 | TTN | HTA12-26-1 | Human | Pancreas | PDAC | 1.84e-07 | 4.56e-01 | 0.3728 |
| 7273 | TTN | HTA12-29-1 | Human | Pancreas | PDAC | 3.65e-29 | 6.66e-01 | 0.3722 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00069371 | Colorectum | FAP | regulation of muscle contraction | 37/2622 | 169/18723 | 3.39e-03 | 2.47e-02 | 37 |
| GO:00970622 | Colorectum | FAP | dendritic spine maintenance | 8/2622 | 21/18723 | 5.43e-03 | 3.53e-02 | 8 |
| GO:0098885 | Colorectum | FAP | modification of postsynaptic actin cytoskeleton | 5/2622 | 10/18723 | 7.32e-03 | 4.38e-02 | 5 |
| GO:00070155 | Colorectum | CRC | actin filament organization | 104/2078 | 442/18723 | 4.75e-14 | 7.12e-11 | 104 |
| GO:00329705 | Colorectum | CRC | regulation of actin filament-based process | 89/2078 | 397/18723 | 5.25e-11 | 3.14e-08 | 89 |
| GO:00315894 | Colorectum | CRC | cell-substrate adhesion | 78/2078 | 363/18723 | 6.22e-09 | 1.49e-06 | 78 |
| GO:00432545 | Colorectum | CRC | regulation of protein-containing complex assembly | 87/2078 | 428/18723 | 1.38e-08 | 2.67e-06 | 87 |
| GO:00160494 | Colorectum | CRC | cell growth | 95/2078 | 482/18723 | 1.51e-08 | 2.75e-06 | 95 |
| GO:19029035 | Colorectum | CRC | regulation of supramolecular fiber organization | 80/2078 | 383/18723 | 1.52e-08 | 2.75e-06 | 80 |
| GO:00329565 | Colorectum | CRC | regulation of actin cytoskeleton organization | 76/2078 | 358/18723 | 1.68e-08 | 2.79e-06 | 76 |
| GO:01100535 | Colorectum | CRC | regulation of actin filament organization | 63/2078 | 278/18723 | 2.21e-08 | 3.23e-06 | 63 |
| GO:00325354 | Colorectum | CRC | regulation of cellular component size | 79/2078 | 383/18723 | 3.30e-08 | 4.60e-06 | 79 |
| GO:00322715 | Colorectum | CRC | regulation of protein polymerization | 55/2078 | 233/18723 | 3.97e-08 | 5.28e-06 | 55 |
| GO:00343294 | Colorectum | CRC | cell junction assembly | 83/2078 | 420/18723 | 1.08e-07 | 1.29e-05 | 83 |
| GO:00512585 | Colorectum | CRC | protein polymerization | 64/2078 | 297/18723 | 1.26e-07 | 1.45e-05 | 64 |
| GO:00081545 | Colorectum | CRC | actin polymerization or depolymerization | 51/2078 | 218/18723 | 1.65e-07 | 1.72e-05 | 51 |
| GO:00070444 | Colorectum | CRC | cell-substrate junction assembly | 29/2078 | 95/18723 | 2.34e-07 | 2.27e-05 | 29 |
| GO:00975815 | Colorectum | CRC | lamellipodium organization | 28/2078 | 90/18723 | 2.43e-07 | 2.27e-05 | 28 |
| GO:01501154 | Colorectum | CRC | cell-substrate junction organization | 30/2078 | 101/18723 | 2.85e-07 | 2.54e-05 | 30 |
| GO:00605603 | Colorectum | CRC | developmental growth involved in morphogenesis | 53/2078 | 234/18723 | 2.88e-07 | 2.54e-05 | 53 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa054142 | Lung | AIS | Dilated cardiomyopathy | 22/961 | 96/8465 | 9.02e-04 | 7.11e-03 | 4.55e-03 | 22 |
| hsa054102 | Lung | AIS | Hypertrophic cardiomyopathy | 20/961 | 90/8465 | 2.25e-03 | 1.37e-02 | 8.80e-03 | 20 |
| hsa054143 | Lung | AIS | Dilated cardiomyopathy | 22/961 | 96/8465 | 9.02e-04 | 7.11e-03 | 4.55e-03 | 22 |
| hsa054103 | Lung | AIS | Hypertrophic cardiomyopathy | 20/961 | 90/8465 | 2.25e-03 | 1.37e-02 | 8.80e-03 | 20 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TTN | SNV | Missense_Mutation | rs557526069 | c.35041G>A | p.Glu11681Lys | p.E11681K | protein_coding | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |||
| TTN | SNV | Missense_Mutation | novel | c.31372N>C | p.Val10458Leu | p.V10458L | protein_coding | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
| TTN | SNV | Missense_Mutation | c.69142N>A | p.Glu23048Lys | p.E23048K | protein_coding | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||||
| TTN | SNV | Missense_Mutation | novel | c.105331G>C | p.Glu35111Gln | p.E35111Q | protein_coding | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |||
| TTN | SNV | Missense_Mutation | novel | c.91713G>A | p.Met30571Ile | p.M30571I | protein_coding | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |||
| TTN | SNV | Missense_Mutation | c.31520A>T | p.Glu10507Val | p.E10507V | protein_coding | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||||
| TTN | SNV | Missense_Mutation | novel | c.43021N>A | p.Glu14341Lys | p.E14341K | protein_coding | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |||
| TTN | SNV | Missense_Mutation | c.58960N>T | p.Val19654Phe | p.V19654F | protein_coding | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | ||||
| TTN | SNV | Missense_Mutation | novel | c.38183N>T | p.Lys12728Ile | p.K12728I | protein_coding | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |||
| TTN | SNV | Missense_Mutation | novel | c.10739C>G | p.Ala3580Gly | p.A3580G | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7273 | TTN | DRUGGABLE GENOME, TYROSINE KINASE, SERINE THREONINE KINASE, KINASE, ENZYME | PROTEASE INHIBITORS | 9648223 |
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