Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TNFRSF21_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TNFRSF21_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TNFRSF21_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/TNFRSF21_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TNFRSF21_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/TNFRSF21_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TNFRSF21_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/TNFRSF21_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TNFRSF21_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071595 | Stomach | SIM | leukocyte cell-cell adhesion | 33/708 | 371/18723 | 5.16e-06 | 2.08e-04 | 33 |
GO:00508635 | Stomach | SIM | regulation of T cell activation | 29/708 | 329/18723 | 2.26e-05 | 7.00e-04 | 29 |
GO:00706614 | Stomach | SIM | leukocyte proliferation | 28/708 | 318/18723 | 3.17e-05 | 9.35e-04 | 28 |
GO:00420984 | Stomach | SIM | T cell proliferation | 20/708 | 199/18723 | 6.96e-05 | 1.79e-03 | 20 |
GO:00421104 | Stomach | SIM | T cell activation | 36/708 | 487/18723 | 1.05e-04 | 2.54e-03 | 36 |
GO:00069595 | Stomach | SIM | humoral immune response | 26/708 | 317/18723 | 1.91e-04 | 4.00e-03 | 26 |
GO:00026835 | Stomach | SIM | negative regulation of immune system process | 32/708 | 434/18723 | 2.63e-04 | 5.10e-03 | 32 |
GO:00706634 | Stomach | SIM | regulation of leukocyte proliferation | 21/708 | 245/18723 | 4.29e-04 | 7.26e-03 | 21 |
GO:00466514 | Stomach | SIM | lymphocyte proliferation | 23/708 | 288/18723 | 6.35e-04 | 9.41e-03 | 23 |
GO:00329433 | Stomach | SIM | mononuclear cell proliferation | 23/708 | 291/18723 | 7.32e-04 | 1.04e-02 | 23 |
GO:00421294 | Stomach | SIM | regulation of T cell proliferation | 16/708 | 171/18723 | 7.91e-04 | 1.08e-02 | 16 |
GO:00224082 | Stomach | SIM | negative regulation of cell-cell adhesion | 17/708 | 196/18723 | 1.28e-03 | 1.59e-02 | 17 |
GO:007099751 | Stomach | SIM | neuron death | 26/708 | 361/18723 | 1.34e-03 | 1.66e-02 | 26 |
GO:00506703 | Stomach | SIM | regulation of lymphocyte proliferation | 18/708 | 225/18723 | 2.32e-03 | 2.36e-02 | 18 |
GO:00329442 | Stomach | SIM | regulation of mononuclear cell proliferation | 18/708 | 227/18723 | 2.55e-03 | 2.54e-02 | 18 |
GO:000716221 | Stomach | SIM | negative regulation of cell adhesion | 22/708 | 303/18723 | 2.76e-03 | 2.69e-02 | 22 |
GO:005140251 | Stomach | SIM | neuron apoptotic process | 18/708 | 246/18723 | 5.93e-03 | 4.81e-02 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF21 | SNV | Missense_Mutation | | c.1600N>A | p.Ala534Thr | p.A534T | O75509 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
TNFRSF21 | insertion | In_Frame_Ins | novel | c.420_421insTATACCAAAGATGTTTTCTCCATTTCGTGTATTCCAAAG | p.Ser140_Asn141insTyrThrLysAspValPheSerIleSerCysIleProLys | p.S140_N141insYTKDVFSISCIPK | O75509 | protein_coding | | | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
TNFRSF21 | insertion | Frame_Shift_Ins | novel | c.1319_1320insACACACACACACACGCATACGCCTGCACA | p.Ser441HisfsTer48 | p.S441Hfs*48 | O75509 | protein_coding | | | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TNFRSF21 | SNV | Missense_Mutation | rs781439087 | c.1414G>A | p.Glu472Lys | p.E472K | O75509 | protein_coding | deleterious(0.01) | benign(0.266) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNFRSF21 | SNV | Missense_Mutation | | c.1224N>G | p.Ile408Met | p.I408M | O75509 | protein_coding | deleterious(0.04) | possibly_damaging(0.779) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | | c.1036N>G | p.Ile346Val | p.I346V | O75509 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EK-A2RE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | rs778427574 | c.1769N>A | p.Arg590His | p.R590H | O75509 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | | c.1376N>T | p.Ala459Val | p.A459V | O75509 | protein_coding | deleterious(0) | possibly_damaging(0.64) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | rs867596127 | c.1483N>T | p.Arg495Cys | p.R495C | O75509 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TNFRSF21 | SNV | Missense_Mutation | | c.1363G>A | p.Asp455Asn | p.D455N | O75509 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |