Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/TK1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TK1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TK1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TK1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TK1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TK1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TK1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TK1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19908454 | Oral cavity | OSCC | adaptive thermogenesis | 76/7305 | 157/18723 | 1.02e-02 | 3.52e-02 | 76 |
GO:00518967 | Oral cavity | OSCC | regulation of protein kinase B signaling | 88/7305 | 185/18723 | 1.07e-02 | 3.64e-02 | 88 |
GO:200037717 | Oral cavity | LP | regulation of reactive oxygen species metabolic process | 67/4623 | 157/18723 | 5.54e-07 | 1.51e-05 | 67 |
GO:190165711 | Oral cavity | LP | glycosyl compound metabolic process | 43/4623 | 88/18723 | 7.80e-07 | 2.05e-05 | 43 |
GO:000912411 | Oral cavity | LP | nucleoside monophosphate biosynthetic process | 24/4623 | 42/18723 | 7.17e-06 | 1.37e-04 | 24 |
GO:007189715 | Oral cavity | LP | DNA biosynthetic process | 71/4623 | 180/18723 | 8.04e-06 | 1.52e-04 | 71 |
GO:000912312 | Oral cavity | LP | nucleoside monophosphate metabolic process | 36/4623 | 76/18723 | 1.46e-05 | 2.57e-04 | 36 |
GO:000911611 | Oral cavity | LP | nucleoside metabolic process | 31/4623 | 62/18723 | 1.46e-05 | 2.57e-04 | 31 |
GO:000675319 | Oral cavity | LP | nucleoside phosphate metabolic process | 161/4623 | 497/18723 | 5.31e-05 | 7.39e-04 | 161 |
GO:00512591 | Oral cavity | LP | protein complex oligomerization | 85/4623 | 238/18723 | 8.81e-05 | 1.11e-03 | 85 |
GO:007259317 | Oral cavity | LP | reactive oxygen species metabolic process | 85/4623 | 239/18723 | 1.04e-04 | 1.26e-03 | 85 |
GO:00443461 | Oral cavity | LP | fibroblast apoptotic process | 13/4623 | 22/18723 | 6.11e-04 | 5.58e-03 | 13 |
GO:005126211 | Oral cavity | LP | protein tetramerization | 35/4623 | 87/18723 | 9.81e-04 | 8.28e-03 | 35 |
GO:000963619 | Oral cavity | LP | response to toxic substance | 86/4623 | 262/18723 | 1.74e-03 | 1.32e-02 | 86 |
GO:190129315 | Oral cavity | LP | nucleoside phosphate biosynthetic process | 84/4623 | 256/18723 | 1.98e-03 | 1.47e-02 | 84 |
GO:199074819 | Oral cavity | LP | cellular detoxification | 43/4623 | 116/18723 | 1.99e-03 | 1.47e-02 | 43 |
GO:000657512 | Oral cavity | LP | cellular modified amino acid metabolic process | 64/4623 | 188/18723 | 2.43e-03 | 1.73e-02 | 64 |
GO:000679012 | Oral cavity | LP | sulfur compound metabolic process | 106/4623 | 339/18723 | 3.36e-03 | 2.25e-02 | 106 |
GO:00091623 | Oral cavity | LP | deoxyribonucleoside monophosphate metabolic process | 12/4623 | 23/18723 | 4.14e-03 | 2.66e-02 | 12 |
GO:009723719 | Oral cavity | LP | cellular response to toxic substance | 44/4623 | 124/18723 | 4.61e-03 | 2.93e-02 | 44 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TK1 | SNV | Missense_Mutation | rs373525383 | c.197G>A | p.Cys66Tyr | p.C66Y | P04183 | protein_coding | tolerated(0.66) | benign(0) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TK1 | insertion | Nonsense_Mutation | novel | c.124_125insATTTGAACATTGAATGATTCAAATCAGCACACTTTCCAAGG | p.Arg42HisfsTer6 | p.R42Hfs*6 | P04183 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TK1 | insertion | Nonsense_Mutation | novel | c.177_178insTGGTTTGGCCTGCACGTTGATTTTTGTTTAATTTTTTAGTTGTC | p.Arg60TrpfsTer13 | p.R60Wfs*13 | P04183 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
TK1 | SNV | Missense_Mutation | | c.697N>A | p.Ala233Thr | p.A233T | P04183 | protein_coding | tolerated_low_confidence(0.05) | benign(0.001) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TK1 | SNV | Missense_Mutation | novel | c.536N>G | p.Asp179Gly | p.D179G | P04183 | protein_coding | deleterious(0.01) | benign(0.228) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
TK1 | SNV | Missense_Mutation | rs375708499 | c.245G>A | p.Arg82Gln | p.R82Q | P04183 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-CM-5349-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TK1 | SNV | Missense_Mutation | | c.527N>T | p.Gly176Val | p.G176V | P04183 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DM-A28F-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TK1 | SNV | Missense_Mutation | rs746414831 | c.224N>T | p.Ala75Val | p.A75V | P04183 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TK1 | SNV | Missense_Mutation | novel | c.236N>A | p.Cys79Tyr | p.C79Y | P04183 | protein_coding | deleterious(0.04) | benign(0.08) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TK1 | SNV | Missense_Mutation | | c.612G>T | p.Glu204Asp | p.E204D | P04183 | protein_coding | tolerated(0.08) | benign(0.132) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | zidovudine | ZIDOVUDINE | 22960662 |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy | | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | Ad-OC-hsvTK/valacyclovir | | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | HQK-1004 | ARGININE BUTYRATE | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | Radiosensitizer gene therapy | | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | TK-DLI | | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | FV-100 | VALNIVUDINE HYDROCHLORIDE | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | Penciclovir | PENCICLOVIR | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | DEOXYCYTIDINE | DEOXYCYTIDINE | |
7083 | TK1 | ENZYME, KINASE, DRUGGABLE GENOME | | Rilapladib | RILAPLADIB | |