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Gene: SNAI2 |
Gene summary for SNAI2 |
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Gene information | Species | Human | Gene symbol | SNAI2 | Gene ID | 6591 |
Gene name | snail family transcriptional repressor 2 | |
Gene Alias | SLUG | |
Cytomap | 8q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O43623 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6591 | SNAI2 | LZE4T | Human | Esophagus | ESCC | 7.04e-08 | 5.18e-01 | 0.0811 |
6591 | SNAI2 | P2T-E | Human | Esophagus | ESCC | 8.09e-25 | 6.78e-01 | 0.1177 |
6591 | SNAI2 | P4T-E | Human | Esophagus | ESCC | 2.85e-06 | 4.37e-01 | 0.1323 |
6591 | SNAI2 | P5T-E | Human | Esophagus | ESCC | 1.69e-14 | 3.65e-01 | 0.1327 |
6591 | SNAI2 | P8T-E | Human | Esophagus | ESCC | 7.07e-03 | -1.94e-02 | 0.0889 |
6591 | SNAI2 | P9T-E | Human | Esophagus | ESCC | 4.77e-13 | 6.01e-01 | 0.1131 |
6591 | SNAI2 | P10T-E | Human | Esophagus | ESCC | 2.78e-26 | 7.35e-01 | 0.116 |
6591 | SNAI2 | P11T-E | Human | Esophagus | ESCC | 4.46e-06 | 1.04e+00 | 0.1426 |
6591 | SNAI2 | P12T-E | Human | Esophagus | ESCC | 3.92e-11 | 5.65e-01 | 0.1122 |
6591 | SNAI2 | P15T-E | Human | Esophagus | ESCC | 1.80e-18 | 7.42e-01 | 0.1149 |
6591 | SNAI2 | P16T-E | Human | Esophagus | ESCC | 1.49e-41 | 1.16e+00 | 0.1153 |
6591 | SNAI2 | P20T-E | Human | Esophagus | ESCC | 7.73e-19 | 7.65e-01 | 0.1124 |
6591 | SNAI2 | P21T-E | Human | Esophagus | ESCC | 3.58e-26 | 1.07e+00 | 0.1617 |
6591 | SNAI2 | P22T-E | Human | Esophagus | ESCC | 1.94e-34 | 9.31e-01 | 0.1236 |
6591 | SNAI2 | P23T-E | Human | Esophagus | ESCC | 6.10e-10 | 8.17e-01 | 0.108 |
6591 | SNAI2 | P26T-E | Human | Esophagus | ESCC | 2.56e-26 | 8.40e-01 | 0.1276 |
6591 | SNAI2 | P27T-E | Human | Esophagus | ESCC | 3.40e-14 | 3.81e-01 | 0.1055 |
6591 | SNAI2 | P28T-E | Human | Esophagus | ESCC | 4.22e-07 | 3.55e-01 | 0.1149 |
6591 | SNAI2 | P30T-E | Human | Esophagus | ESCC | 8.36e-41 | 2.05e+00 | 0.137 |
6591 | SNAI2 | P31T-E | Human | Esophagus | ESCC | 3.75e-24 | 7.89e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000704316 | Prostate | BPH | cell-cell junction assembly | 39/3107 | 146/18723 | 1.30e-03 | 7.83e-03 | 39 |
GO:00380345 | Prostate | BPH | signal transduction in absence of ligand | 21/3107 | 65/18723 | 1.37e-03 | 8.19e-03 | 21 |
GO:00971925 | Prostate | BPH | extrinsic apoptotic signaling pathway in absence of ligand | 21/3107 | 65/18723 | 1.37e-03 | 8.19e-03 | 21 |
GO:01201929 | Prostate | BPH | tight junction assembly | 23/3107 | 74/18723 | 1.49e-03 | 8.85e-03 | 23 |
GO:00436165 | Prostate | BPH | keratinocyte proliferation | 16/3107 | 46/18723 | 2.11e-03 | 1.18e-02 | 16 |
GO:00301786 | Prostate | BPH | negative regulation of Wnt signaling pathway | 43/3107 | 170/18723 | 2.42e-03 | 1.31e-02 | 43 |
GO:00030073 | Prostate | BPH | heart morphogenesis | 58/3107 | 246/18723 | 2.86e-03 | 1.50e-02 | 58 |
GO:00900903 | Prostate | BPH | negative regulation of canonical Wnt signaling pathway | 35/3107 | 137/18723 | 4.90e-03 | 2.32e-02 | 35 |
GO:2000810 | Prostate | BPH | regulation of bicellular tight junction assembly | 9/3107 | 23/18723 | 8.32e-03 | 3.60e-02 | 9 |
GO:00708307 | Prostate | BPH | bicellular tight junction assembly | 20/3107 | 70/18723 | 8.38e-03 | 3.62e-02 | 20 |
GO:19017973 | Prostate | BPH | negative regulation of signal transduction by p53 class mediator | 11/3107 | 31/18723 | 8.57e-03 | 3.68e-02 | 11 |
GO:00072195 | Prostate | BPH | Notch signaling pathway | 41/3107 | 172/18723 | 8.95e-03 | 3.83e-02 | 41 |
GO:00075848 | Prostate | BPH | response to nutrient | 41/3107 | 174/18723 | 1.09e-02 | 4.50e-02 | 41 |
GO:20010212 | Prostate | BPH | negative regulation of response to DNA damage stimulus | 22/3107 | 81/18723 | 1.10e-02 | 4.53e-02 | 22 |
GO:200123319 | Prostate | Tumor | regulation of apoptotic signaling pathway | 137/3246 | 356/18723 | 1.01e-21 | 1.25e-18 | 137 |
GO:009719319 | Prostate | Tumor | intrinsic apoptotic signaling pathway | 113/3246 | 288/18723 | 6.79e-19 | 2.64e-16 | 113 |
GO:200124219 | Prostate | Tumor | regulation of intrinsic apoptotic signaling pathway | 72/3246 | 164/18723 | 1.63e-15 | 2.81e-13 | 72 |
GO:009719119 | Prostate | Tumor | extrinsic apoptotic signaling pathway | 81/3246 | 219/18723 | 2.48e-12 | 2.20e-10 | 81 |
GO:200123419 | Prostate | Tumor | negative regulation of apoptotic signaling pathway | 81/3246 | 224/18723 | 9.57e-12 | 7.53e-10 | 81 |
GO:007149619 | Prostate | Tumor | cellular response to external stimulus | 103/3246 | 320/18723 | 5.29e-11 | 3.41e-09 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0452029 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa04520113 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0452027 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa0439010 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa04520112 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa0439015 | Prostate | BPH | Hippo signaling pathway | 52/1718 | 157/8465 | 9.93e-05 | 6.00e-04 | 3.71e-04 | 52 |
hsa0452028 | Prostate | Tumor | Adherens junction | 53/1791 | 93/8465 | 3.68e-14 | 8.11e-13 | 5.03e-13 | 53 |
hsa0439024 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
hsa0452036 | Prostate | Tumor | Adherens junction | 53/1791 | 93/8465 | 3.68e-14 | 8.11e-13 | 5.03e-13 | 53 |
hsa0439034 | Prostate | Tumor | Hippo signaling pathway | 54/1791 | 157/8465 | 7.52e-05 | 5.30e-04 | 3.28e-04 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNAI2 | SNV | Missense_Mutation | novel | c.709N>A | p.Asp237Asn | p.D237N | O43623 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | novel | c.750N>A | p.Phe250Leu | p.F250L | O43623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNAI2 | SNV | Missense_Mutation | novel | c.473N>A | p.Ser158Tyr | p.S158Y | O43623 | protein_coding | tolerated(1) | benign(0.025) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNAI2 | SNV | Missense_Mutation | novel | c.373N>A | p.Ala125Thr | p.A125T | O43623 | protein_coding | tolerated(0.11) | benign(0.283) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNAI2 | SNV | Missense_Mutation | c.89C>T | p.Ser30Phe | p.S30F | O43623 | protein_coding | tolerated(0.65) | possibly_damaging(0.459) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SNAI2 | SNV | Missense_Mutation | novel | c.783N>T | p.Glu261Asp | p.E261D | O43623 | protein_coding | tolerated(0.1) | benign(0.062) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SNAI2 | SNV | Missense_Mutation | c.422N>T | p.Ser141Phe | p.S141F | O43623 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNAI2 | SNV | Missense_Mutation | novel | c.359C>T | p.Pro120Leu | p.P120L | O43623 | protein_coding | deleterious(0.02) | benign(0.01) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | novel | c.750C>A | p.Phe250Leu | p.F250L | O43623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNAI2 | SNV | Missense_Mutation | c.83N>G | p.Ile28Ser | p.I28S | O43623 | protein_coding | tolerated(0.5) | benign(0.006) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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