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Gene: PTGES3 |
Gene summary for PTGES3 |
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Gene information | Species | Human | Gene symbol | PTGES3 | Gene ID | 10728 |
Gene name | prostaglandin E synthase 3 | |
Gene Alias | P23 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q15185 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10728 | PTGES3 | GSM4909285 | Human | Breast | IDC | 3.31e-13 | 4.66e-01 | 0.21 |
10728 | PTGES3 | GSM4909286 | Human | Breast | IDC | 1.09e-07 | -1.84e-01 | 0.1081 |
10728 | PTGES3 | GSM4909288 | Human | Breast | IDC | 1.15e-03 | 4.81e-02 | 0.0988 |
10728 | PTGES3 | GSM4909293 | Human | Breast | IDC | 8.33e-06 | 2.24e-01 | 0.1581 |
10728 | PTGES3 | GSM4909294 | Human | Breast | IDC | 3.17e-22 | 2.98e-01 | 0.2022 |
10728 | PTGES3 | GSM4909296 | Human | Breast | IDC | 2.32e-23 | -4.90e-01 | 0.1524 |
10728 | PTGES3 | GSM4909297 | Human | Breast | IDC | 5.46e-23 | 1.75e-02 | 0.1517 |
10728 | PTGES3 | GSM4909301 | Human | Breast | IDC | 2.23e-02 | -2.27e-01 | 0.1577 |
10728 | PTGES3 | GSM4909302 | Human | Breast | IDC | 4.52e-04 | -2.84e-01 | 0.1545 |
10728 | PTGES3 | GSM4909311 | Human | Breast | IDC | 1.24e-52 | -6.49e-01 | 0.1534 |
10728 | PTGES3 | GSM4909312 | Human | Breast | IDC | 3.05e-14 | -2.09e-01 | 0.1552 |
10728 | PTGES3 | GSM4909313 | Human | Breast | IDC | 2.55e-07 | -2.76e-01 | 0.0391 |
10728 | PTGES3 | GSM4909315 | Human | Breast | IDC | 2.19e-28 | 5.13e-01 | 0.21 |
10728 | PTGES3 | GSM4909316 | Human | Breast | IDC | 6.81e-03 | 8.40e-02 | 0.21 |
10728 | PTGES3 | GSM4909317 | Human | Breast | IDC | 2.79e-05 | 3.30e-01 | 0.1355 |
10728 | PTGES3 | GSM4909318 | Human | Breast | IDC | 4.14e-09 | 4.08e-01 | 0.2031 |
10728 | PTGES3 | GSM4909319 | Human | Breast | IDC | 1.12e-53 | -5.35e-01 | 0.1563 |
10728 | PTGES3 | GSM4909320 | Human | Breast | IDC | 4.61e-09 | -5.48e-01 | 0.1575 |
10728 | PTGES3 | GSM4909321 | Human | Breast | IDC | 3.61e-36 | 3.98e-01 | 0.1559 |
10728 | PTGES3 | brca1 | Human | Breast | Precancer | 3.64e-05 | 2.84e-01 | -0.0338 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007182627 | Esophagus | HGIN | ribonucleoprotein complex subunit organization | 84/2587 | 227/18723 | 1.34e-18 | 5.37e-16 | 84 |
GO:002261827 | Esophagus | HGIN | ribonucleoprotein complex assembly | 82/2587 | 220/18723 | 2.07e-18 | 7.36e-16 | 82 |
GO:003164727 | Esophagus | HGIN | regulation of protein stability | 96/2587 | 298/18723 | 2.21e-16 | 5.76e-14 | 96 |
GO:000645720 | Esophagus | HGIN | protein folding | 75/2587 | 212/18723 | 1.61e-15 | 3.86e-13 | 75 |
GO:005082127 | Esophagus | HGIN | protein stabilization | 64/2587 | 191/18723 | 3.11e-12 | 4.24e-10 | 64 |
GO:006107720 | Esophagus | HGIN | chaperone-mediated protein folding | 27/2587 | 67/18723 | 7.99e-08 | 4.20e-06 | 27 |
GO:000645820 | Esophagus | HGIN | 'de novo' protein folding | 19/2587 | 43/18723 | 1.25e-06 | 4.83e-05 | 19 |
GO:000072318 | Esophagus | HGIN | telomere maintenance | 38/2587 | 131/18723 | 4.38e-06 | 1.42e-04 | 38 |
GO:005105214 | Esophagus | HGIN | regulation of DNA metabolic process | 79/2587 | 359/18723 | 1.38e-05 | 3.85e-04 | 79 |
GO:003052220 | Esophagus | HGIN | intracellular receptor signaling pathway | 62/2587 | 265/18723 | 1.63e-05 | 4.50e-04 | 62 |
GO:005108420 | Esophagus | HGIN | 'de novo' posttranslational protein folding | 16/2587 | 39/18723 | 2.70e-05 | 7.03e-04 | 16 |
GO:004854527 | Esophagus | HGIN | response to steroid hormone | 73/2587 | 339/18723 | 6.06e-05 | 1.40e-03 | 73 |
GO:005108520 | Esophagus | HGIN | chaperone cofactor-dependent protein refolding | 14/2587 | 34/18723 | 8.15e-05 | 1.80e-03 | 14 |
GO:007189710 | Esophagus | HGIN | DNA biosynthetic process | 44/2587 | 180/18723 | 8.97e-05 | 1.96e-03 | 44 |
GO:005105416 | Esophagus | HGIN | positive regulation of DNA metabolic process | 47/2587 | 201/18723 | 1.65e-04 | 3.21e-03 | 47 |
GO:00066929 | Esophagus | HGIN | prostanoid metabolic process | 17/2587 | 49/18723 | 1.84e-04 | 3.48e-03 | 17 |
GO:00066939 | Esophagus | HGIN | prostaglandin metabolic process | 17/2587 | 49/18723 | 1.84e-04 | 3.48e-03 | 17 |
GO:000700417 | Esophagus | HGIN | telomere maintenance via telomerase | 21/2587 | 69/18723 | 2.80e-04 | 4.80e-03 | 21 |
GO:00322007 | Esophagus | HGIN | telomere organization | 38/2587 | 159/18723 | 4.23e-04 | 6.39e-03 | 38 |
GO:200027819 | Esophagus | HGIN | regulation of DNA biosynthetic process | 28/2587 | 106/18723 | 4.30e-04 | 6.47e-03 | 28 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa052071 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGES3 | SNV | Missense_Mutation | novel | c.44N>A | p.Arg15Gln | p.R15Q | protein_coding | tolerated(0.06) | possibly_damaging(0.479) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | c.215G>C | p.Arg72Thr | p.R72T | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-D8-A27N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol+adriamycin+cyclophosphamide+herceptin | SD | ||
PTGES3 | SNV | Missense_Mutation | c.127A>G | p.Ser43Gly | p.S43G | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.112N>C | p.Ser38Pro | p.S38P | protein_coding | tolerated(0.08) | possibly_damaging(0.631) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PTGES3 | SNV | Missense_Mutation | c.365N>G | p.Ser122Cys | p.S122C | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.398A>G | p.Asn133Ser | p.N133S | protein_coding | tolerated(0.25) | benign(0.02) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | c.28G>A | p.Ala10Thr | p.A10T | protein_coding | tolerated(0.53) | benign(0.343) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.232T>G | p.Leu78Val | p.L78V | protein_coding | tolerated(0.38) | benign(0.143) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | novel | c.403N>T | p.Gly135Cys | p.G135C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | novel | c.20N>A | p.Pro7His | p.P7H | protein_coding | tolerated(0.24) | benign(0.108) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10728 | PTGES3 | ENZYME | GENISTEIN | GENISTEIN | 15229138 | |
10728 | PTGES3 | ENZYME | DIETHYLSTILBESTROL | DIETHYLSTILBESTROL | 15229138 | |
10728 | PTGES3 | ENZYME | GEDUNIN | GEDUNIN | 25756299 |
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