Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PPARA_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PPARA_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PPARA_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PPARA_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00061643 | Colorectum | FAP | purine nucleotide biosynthetic process | 44/2622 | 191/18723 | 4.96e-04 | 5.71e-03 | 44 |
GO:00973053 | Colorectum | FAP | response to alcohol | 55/2622 | 253/18723 | 5.05e-04 | 5.78e-03 | 55 |
GO:00507924 | Colorectum | FAP | regulation of viral process | 39/2622 | 164/18723 | 5.21e-04 | 5.91e-03 | 39 |
GO:00435022 | Colorectum | FAP | regulation of muscle adaptation | 26/2622 | 98/18723 | 7.75e-04 | 8.17e-03 | 26 |
GO:00463903 | Colorectum | FAP | ribose phosphate biosynthetic process | 43/2622 | 190/18723 | 8.40e-04 | 8.72e-03 | 43 |
GO:0010675 | Colorectum | FAP | regulation of cellular carbohydrate metabolic process | 35/2622 | 146/18723 | 8.41e-04 | 8.72e-03 | 35 |
GO:00091453 | Colorectum | FAP | purine nucleoside triphosphate biosynthetic process | 20/2622 | 69/18723 | 9.25e-04 | 9.26e-03 | 20 |
GO:19012153 | Colorectum | FAP | negative regulation of neuron death | 46/2622 | 208/18723 | 9.52e-04 | 9.42e-03 | 46 |
GO:00085441 | Colorectum | FAP | epidermis development | 66/2622 | 324/18723 | 9.63e-04 | 9.51e-03 | 66 |
GO:19039004 | Colorectum | FAP | regulation of viral life cycle | 35/2622 | 148/18723 | 1.09e-03 | 1.05e-02 | 35 |
GO:00160423 | Colorectum | FAP | lipid catabolic process | 65/2622 | 320/18723 | 1.13e-03 | 1.08e-02 | 65 |
GO:00450693 | Colorectum | FAP | regulation of viral genome replication | 23/2622 | 85/18723 | 1.14e-03 | 1.09e-02 | 23 |
GO:00620131 | Colorectum | FAP | positive regulation of small molecule metabolic process | 34/2622 | 143/18723 | 1.15e-03 | 1.10e-02 | 34 |
GO:0017015 | Colorectum | FAP | regulation of transforming growth factor beta receptor signaling pathway | 31/2622 | 128/18723 | 1.35e-03 | 1.24e-02 | 31 |
GO:00725223 | Colorectum | FAP | purine-containing compound biosynthetic process | 44/2622 | 200/18723 | 1.35e-03 | 1.24e-02 | 44 |
GO:00091414 | Colorectum | FAP | nucleoside triphosphate metabolic process | 28/2622 | 112/18723 | 1.35e-03 | 1.24e-02 | 28 |
GO:2001171 | Colorectum | FAP | positive regulation of ATP biosynthetic process | 7/2622 | 14/18723 | 1.45e-03 | 1.31e-02 | 7 |
GO:19035792 | Colorectum | FAP | negative regulation of ATP metabolic process | 11/2622 | 30/18723 | 1.66e-03 | 1.46e-02 | 11 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:00071621 | Colorectum | FAP | negative regulation of cell adhesion | 61/2622 | 303/18723 | 1.96e-03 | 1.65e-02 | 61 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa051601 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa049322 | Colorectum | SER | Non-alcoholic fatty liver disease | 75/1580 | 155/8465 | 2.16e-17 | 5.99e-16 | 4.35e-16 | 75 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa054153 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa049323 | Colorectum | SER | Non-alcoholic fatty liver disease | 75/1580 | 155/8465 | 2.16e-17 | 5.99e-16 | 4.35e-16 | 75 |
hsa049223 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa054158 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa049328 | Colorectum | FAP | Non-alcoholic fatty liver disease | 54/1404 | 155/8465 | 1.98e-08 | 6.20e-07 | 3.77e-07 | 54 |
hsa049226 | Colorectum | FAP | Glucagon signaling pathway | 32/1404 | 107/8465 | 4.08e-04 | 3.10e-03 | 1.89e-03 | 32 |
hsa049312 | Colorectum | FAP | Insulin resistance | 32/1404 | 108/8465 | 4.90e-04 | 3.56e-03 | 2.16e-03 | 32 |
hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa054159 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PPARA | MVA | Breast | Healthy | TNFRSF4,SH3TC1,SLFN11, etc. | 1.51e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
PPARA | MVA | Breast | Precancer | TNFRSF4,SH3TC1,SLFN11, etc. | 2.91e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
PPARA | PVA | Breast | Precancer | TNFRSF4,SH3TC1,SLFN11, etc. | 2.39e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
PPARA | cDC | Lung | IAC | CEP112,PIGL,AL683807.1, etc. | 1.94e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
PPARA | M1MAC | Prostate | Healthy | SLC18B1,PTPN9,TGFBR1, etc. | 1.52e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
PPARA | PTC | Thyroid | ADJ | CCDC69,SAA2,USP43, etc. | 2.14e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
PPARA | TFC | Thyroid | ATC | CCDC69,SAA2,USP43, etc. | 8.84e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
PPARA | iATC | Thyroid | ATC | CCDC69,SAA2,USP43, etc. | 1.25e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | T091317 | T091317 | 20350005 |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | simvastatin | SIMVASTATIN | 23930676,24598718,23252946 |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | BMS-687453 | CHEMBL1089501 | 20218621 |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | GTF505 | | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | ZYH-1 | | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | agonist | 135650110 | CLOFIBRATE | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | GFT14 | | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | agonist | 135650558 | LY-510929 | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | OLEIC ACID | OLEIC ACID | |
5465 | PPARA | TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR | | CIPROFIBRATE | CIPROFIBRATE | |