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Gene: PDLIM5 |
Gene summary for PDLIM5 |
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Gene information | Species | Human | Gene symbol | PDLIM5 | Gene ID | 10611 |
Gene name | PDZ and LIM domain 5 | |
Gene Alias | ENH | |
Cytomap | 4q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q96HC4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10611 | PDLIM5 | GSM4909282 | Human | Breast | IDC | 6.96e-06 | -3.35e-01 | -0.0288 |
10611 | PDLIM5 | GSM4909285 | Human | Breast | IDC | 1.36e-11 | -4.31e-01 | 0.21 |
10611 | PDLIM5 | GSM4909286 | Human | Breast | IDC | 7.58e-05 | -2.91e-01 | 0.1081 |
10611 | PDLIM5 | GSM4909293 | Human | Breast | IDC | 1.51e-10 | -4.20e-01 | 0.1581 |
10611 | PDLIM5 | GSM4909294 | Human | Breast | IDC | 2.23e-16 | -4.69e-01 | 0.2022 |
10611 | PDLIM5 | GSM4909296 | Human | Breast | IDC | 8.65e-16 | -3.89e-01 | 0.1524 |
10611 | PDLIM5 | GSM4909297 | Human | Breast | IDC | 2.88e-12 | -4.11e-01 | 0.1517 |
10611 | PDLIM5 | GSM4909298 | Human | Breast | IDC | 1.23e-04 | 9.56e-02 | 0.1551 |
10611 | PDLIM5 | GSM4909304 | Human | Breast | IDC | 4.33e-02 | -2.89e-01 | 0.1636 |
10611 | PDLIM5 | GSM4909306 | Human | Breast | IDC | 6.30e-05 | -3.61e-01 | 0.1564 |
10611 | PDLIM5 | GSM4909311 | Human | Breast | IDC | 4.62e-24 | -4.38e-01 | 0.1534 |
10611 | PDLIM5 | GSM4909312 | Human | Breast | IDC | 3.34e-09 | -3.16e-01 | 0.1552 |
10611 | PDLIM5 | GSM4909315 | Human | Breast | IDC | 4.30e-10 | -4.20e-01 | 0.21 |
10611 | PDLIM5 | GSM4909319 | Human | Breast | IDC | 4.80e-27 | -4.47e-01 | 0.1563 |
10611 | PDLIM5 | GSM4909320 | Human | Breast | IDC | 9.16e-05 | -4.28e-01 | 0.1575 |
10611 | PDLIM5 | GSM4909321 | Human | Breast | IDC | 2.85e-25 | -5.30e-01 | 0.1559 |
10611 | PDLIM5 | ctrl6 | Human | Breast | Precancer | 5.08e-07 | 5.07e-01 | -0.0061 |
10611 | PDLIM5 | NCCBC14 | Human | Breast | DCIS | 2.88e-08 | -2.69e-01 | 0.2021 |
10611 | PDLIM5 | NCCBC2 | Human | Breast | DCIS | 8.01e-03 | 2.02e-01 | 0.1554 |
10611 | PDLIM5 | NCCBC3 | Human | Breast | DCIS | 1.53e-03 | -2.84e-01 | 0.1198 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00970619 | Skin | AK | dendritic spine organization | 21/1910 | 84/18723 | 7.93e-05 | 1.09e-03 | 21 |
GO:00609975 | Skin | AK | dendritic spine morphogenesis | 17/1910 | 61/18723 | 8.79e-05 | 1.20e-03 | 17 |
GO:00488138 | Skin | AK | dendrite morphogenesis | 30/1910 | 146/18723 | 1.44e-04 | 1.73e-03 | 30 |
GO:00147069 | Skin | AK | striated muscle tissue development | 62/1910 | 384/18723 | 1.79e-04 | 2.06e-03 | 62 |
GO:00991753 | Skin | AK | regulation of postsynapse organization | 21/1910 | 90/18723 | 2.27e-04 | 2.51e-03 | 21 |
GO:00991737 | Skin | AK | postsynapse organization | 32/1910 | 168/18723 | 3.77e-04 | 3.65e-03 | 32 |
GO:00508031 | Skin | AK | regulation of synapse structure or activity | 38/1910 | 218/18723 | 7.06e-04 | 6.01e-03 | 38 |
GO:00508073 | Skin | AK | regulation of synapse organization | 37/1910 | 211/18723 | 7.35e-04 | 6.20e-03 | 37 |
GO:00148965 | Skin | AK | muscle hypertrophy | 21/1910 | 104/18723 | 1.70e-03 | 1.20e-02 | 21 |
GO:00148974 | Skin | AK | striated muscle hypertrophy | 20/1910 | 102/18723 | 3.10e-03 | 1.93e-02 | 20 |
GO:00030129 | Skin | AK | muscle system process | 64/1910 | 452/18723 | 4.32e-03 | 2.52e-02 | 64 |
GO:00033005 | Skin | AK | cardiac muscle hypertrophy | 19/1910 | 99/18723 | 4.96e-03 | 2.79e-02 | 19 |
GO:00550014 | Skin | AK | muscle cell development | 30/1910 | 184/18723 | 6.62e-03 | 3.50e-02 | 30 |
GO:00352653 | Skin | AK | organ growth | 29/1910 | 178/18723 | 7.57e-03 | 3.86e-02 | 29 |
GO:00511468 | Skin | AK | striated muscle cell differentiation | 42/1910 | 283/18723 | 8.46e-03 | 4.19e-02 | 42 |
GO:0034329110 | Skin | SCCIS | cell junction assembly | 52/919 | 420/18723 | 7.89e-10 | 5.23e-07 | 52 |
GO:001635818 | Skin | SCCIS | dendrite development | 36/919 | 243/18723 | 3.00e-09 | 1.45e-06 | 36 |
GO:0016049111 | Skin | SCCIS | cell growth | 49/919 | 482/18723 | 1.17e-06 | 7.78e-05 | 49 |
GO:006053717 | Skin | SCCIS | muscle tissue development | 43/919 | 403/18723 | 1.50e-06 | 8.89e-05 | 43 |
GO:004881314 | Skin | SCCIS | dendrite morphogenesis | 22/919 | 146/18723 | 2.61e-06 | 1.28e-04 | 22 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDLIM5 | SNV | Missense_Mutation | c.160G>C | p.Asp54His | p.D54H | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
PDLIM5 | SNV | Missense_Mutation | c.151N>G | p.Leu51Val | p.L51V | Q96HC4 | protein_coding | tolerated(0.57) | benign(0.017) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PDLIM5 | SNV | Missense_Mutation | novel | c.1148C>T | p.Ser383Phe | p.S383F | Q96HC4 | protein_coding | deleterious(0.01) | benign(0.311) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDLIM5 | SNV | Missense_Mutation | novel | c.82N>A | p.Leu28Met | p.L28M | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A9U7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDLIM5 | SNV | Missense_Mutation | novel | c.1387G>A | p.Ala463Thr | p.A463T | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PDLIM5 | SNV | Missense_Mutation | rs201891054 | c.427N>T | p.Arg143Cys | p.R143C | Q96HC4 | protein_coding | deleterious(0.03) | possibly_damaging(0.764) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
PDLIM5 | SNV | Missense_Mutation | novel | c.218N>A | p.Cys73Tyr | p.C73Y | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
PDLIM5 | SNV | Missense_Mutation | novel | c.1076N>C | p.Leu359Pro | p.L359P | Q96HC4 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PDLIM5 | SNV | Missense_Mutation | novel | c.1334N>A | p.Arg445Gln | p.R445Q | Q96HC4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDLIM5 | SNV | Missense_Mutation | c.1090N>G | p.Ser364Ala | p.S364A | Q96HC4 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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