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Gene: OSBPL8 |
Gene summary for OSBPL8 |
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Gene information | Species | Human | Gene symbol | OSBPL8 | Gene ID | 114882 |
Gene name | oxysterol binding protein like 8 | |
Gene Alias | MST120 | |
Cytomap | 12q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q5HYM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114882 | OSBPL8 | CA_HPV_1 | Human | Cervix | CC | 1.79e-06 | -2.16e-01 | 0.0264 |
114882 | OSBPL8 | CCI_2 | Human | Cervix | CC | 4.99e-06 | 6.05e-01 | 0.5249 |
114882 | OSBPL8 | CCII_1 | Human | Cervix | CC | 1.09e-10 | -6.13e-01 | 0.3249 |
114882 | OSBPL8 | Tumor | Human | Cervix | CC | 9.77e-19 | -5.28e-01 | 0.1241 |
114882 | OSBPL8 | sample1 | Human | Cervix | CC | 2.03e-03 | -4.83e-01 | 0.0959 |
114882 | OSBPL8 | sample3 | Human | Cervix | CC | 1.24e-14 | -4.38e-01 | 0.1387 |
114882 | OSBPL8 | H2 | Human | Cervix | HSIL_HPV | 1.14e-08 | -3.61e-01 | 0.0632 |
114882 | OSBPL8 | L1 | Human | Cervix | CC | 9.00e-09 | -4.87e-01 | 0.0802 |
114882 | OSBPL8 | T1 | Human | Cervix | CC | 1.19e-11 | -5.14e-01 | 0.0918 |
114882 | OSBPL8 | T3 | Human | Cervix | CC | 4.72e-14 | -4.21e-01 | 0.1389 |
114882 | OSBPL8 | LZE4T | Human | Esophagus | ESCC | 8.60e-18 | 5.71e-01 | 0.0811 |
114882 | OSBPL8 | LZE5T | Human | Esophagus | ESCC | 5.94e-05 | 4.97e-01 | 0.0514 |
114882 | OSBPL8 | LZE7T | Human | Esophagus | ESCC | 2.61e-06 | 5.05e-01 | 0.0667 |
114882 | OSBPL8 | LZE8T | Human | Esophagus | ESCC | 3.13e-04 | -8.14e-03 | 0.067 |
114882 | OSBPL8 | LZE20T | Human | Esophagus | ESCC | 1.54e-05 | 1.61e-01 | 0.0662 |
114882 | OSBPL8 | LZE22D1 | Human | Esophagus | HGIN | 2.06e-06 | 7.18e-02 | 0.0595 |
114882 | OSBPL8 | LZE22T | Human | Esophagus | ESCC | 3.02e-04 | 2.21e-01 | 0.068 |
114882 | OSBPL8 | LZE24T | Human | Esophagus | ESCC | 4.02e-14 | 3.84e-01 | 0.0596 |
114882 | OSBPL8 | LZE21T | Human | Esophagus | ESCC | 7.15e-08 | 3.09e-01 | 0.0655 |
114882 | OSBPL8 | LZE6T | Human | Esophagus | ESCC | 6.73e-06 | 1.20e-01 | 0.0845 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005127117 | Thyroid | ATC | negative regulation of cellular component movement | 150/6293 | 367/18723 | 1.99e-03 | 9.54e-03 | 150 |
GO:200014617 | Thyroid | ATC | negative regulation of cell motility | 147/6293 | 359/18723 | 2.01e-03 | 9.60e-03 | 147 |
GO:000657522 | Thyroid | ATC | cellular modified amino acid metabolic process | 82/6293 | 188/18723 | 2.60e-03 | 1.20e-02 | 82 |
GO:004349116 | Thyroid | ATC | protein kinase B signaling | 87/6293 | 211/18723 | 1.20e-02 | 4.27e-02 | 87 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBPL8 | SNV | Missense_Mutation | c.1103C>A | p.Pro368His | p.P368H | Q9BZF1 | protein_coding | tolerated(0.09) | benign(0.416) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
OSBPL8 | SNV | Missense_Mutation | rs201177828 | c.1601N>T | p.Gly534Val | p.G534V | Q9BZF1 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
OSBPL8 | SNV | Missense_Mutation | rs201177828 | c.1601G>T | p.Gly534Val | p.G534V | Q9BZF1 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBPL8 | SNV | Missense_Mutation | rs201177828 | c.1601N>T | p.Gly534Val | p.G534V | Q9BZF1 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBPL8 | SNV | Missense_Mutation | c.1654N>C | p.Glu552Gln | p.E552Q | Q9BZF1 | protein_coding | deleterious(0.01) | benign(0.061) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OSBPL8 | SNV | Missense_Mutation | novel | c.386N>A | p.Arg129Gln | p.R129Q | Q9BZF1 | protein_coding | deleterious(0.02) | probably_damaging(0.957) | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
OSBPL8 | SNV | Missense_Mutation | rs201177828 | c.1601G>T | p.Gly534Val | p.G534V | Q9BZF1 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
OSBPL8 | SNV | Missense_Mutation | c.442G>A | p.Val148Ile | p.V148I | Q9BZF1 | protein_coding | tolerated(0.09) | possibly_damaging(0.562) | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
OSBPL8 | SNV | Missense_Mutation | novel | c.2608N>C | p.Asp870His | p.D870H | Q9BZF1 | protein_coding | tolerated(0.58) | benign(0.001) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
OSBPL8 | SNV | Missense_Mutation | c.602N>A | p.Arg201His | p.R201H | Q9BZF1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D8-A1XF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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