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Gene: LSM14A |
Gene summary for LSM14A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LSM14A | Gene ID | 26065 |
| Gene name | LSM14A mRNA processing body assembly factor | |
| Gene Alias | C19orf13 | |
| Cytomap | 19q13.11 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8ND56 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 26065 | LSM14A | CA_HPV_3 | Human | Cervix | CC | 1.29e-02 | 1.01e-01 | 0.0414 |
| 26065 | LSM14A | CCI_1 | Human | Cervix | CC | 1.72e-02 | 4.84e-01 | 0.528 |
| 26065 | LSM14A | CCI_2 | Human | Cervix | CC | 2.28e-06 | 7.43e-01 | 0.5249 |
| 26065 | LSM14A | CCI_3 | Human | Cervix | CC | 2.90e-04 | 6.28e-01 | 0.516 |
| 26065 | LSM14A | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.75e-09 | -4.16e-01 | 0.0155 |
| 26065 | LSM14A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.83e-02 | 4.43e-01 | 0.281 |
| 26065 | LSM14A | A001-C-207 | Human | Colorectum | FAP | 1.10e-03 | -2.48e-01 | 0.1278 |
| 26065 | LSM14A | A015-C-203 | Human | Colorectum | FAP | 1.51e-26 | -4.68e-01 | -0.1294 |
| 26065 | LSM14A | A015-C-204 | Human | Colorectum | FAP | 3.00e-08 | -2.24e-01 | -0.0228 |
| 26065 | LSM14A | A014-C-040 | Human | Colorectum | FAP | 8.16e-07 | -5.55e-01 | -0.1184 |
| 26065 | LSM14A | A002-C-201 | Human | Colorectum | FAP | 4.07e-16 | -3.64e-01 | 0.0324 |
| 26065 | LSM14A | A002-C-203 | Human | Colorectum | FAP | 1.04e-05 | -1.76e-01 | 0.2786 |
| 26065 | LSM14A | A001-C-119 | Human | Colorectum | FAP | 2.04e-08 | -3.36e-01 | -0.1557 |
| 26065 | LSM14A | A001-C-108 | Human | Colorectum | FAP | 4.55e-19 | -3.33e-01 | -0.0272 |
| 26065 | LSM14A | A002-C-205 | Human | Colorectum | FAP | 2.57e-26 | -4.64e-01 | -0.1236 |
| 26065 | LSM14A | A014-C-108 | Human | Colorectum | FAP | 2.75e-03 | -4.01e-01 | -0.124 |
| 26065 | LSM14A | A001-C-104 | Human | Colorectum | FAP | 2.27e-09 | -3.63e-01 | 0.0184 |
| 26065 | LSM14A | A015-C-005 | Human | Colorectum | FAP | 2.26e-07 | -3.65e-01 | -0.0336 |
| 26065 | LSM14A | A015-C-006 | Human | Colorectum | FAP | 4.76e-18 | -4.91e-01 | -0.0994 |
| 26065 | LSM14A | A015-C-106 | Human | Colorectum | FAP | 3.04e-11 | -2.80e-01 | -0.0511 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
| GO:190285017 | Thyroid | ATC | microtubule cytoskeleton organization involved in mitosis | 95/6293 | 147/18723 | 1.29e-14 | 7.62e-13 | 95 |
| GO:000641735 | Thyroid | ATC | regulation of translation | 236/6293 | 468/18723 | 2.39e-14 | 1.34e-12 | 236 |
| GO:000705222 | Thyroid | ATC | mitotic spindle organization | 80/6293 | 120/18723 | 1.27e-13 | 6.46e-12 | 80 |
| GO:000705122 | Thyroid | ATC | spindle organization | 109/6293 | 184/18723 | 7.99e-13 | 3.46e-11 | 109 |
| GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
| GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
| GO:0030522112 | Thyroid | ATC | intracellular receptor signaling pathway | 134/6293 | 265/18723 | 7.58e-09 | 1.63e-07 | 134 |
| GO:0009615111 | Thyroid | ATC | response to virus | 173/6293 | 367/18723 | 4.23e-08 | 7.71e-07 | 173 |
| GO:005122521 | Thyroid | ATC | spindle assembly | 66/6293 | 117/18723 | 3.28e-07 | 4.88e-06 | 66 |
| GO:003434015 | Thyroid | ATC | response to type I interferon | 38/6293 | 58/18723 | 6.67e-07 | 9.13e-06 | 38 |
| GO:009030721 | Thyroid | ATC | mitotic spindle assembly | 41/6293 | 65/18723 | 1.10e-06 | 1.43e-05 | 41 |
| GO:003406323 | Thyroid | ATC | stress granule assembly | 20/6293 | 26/18723 | 7.65e-06 | 7.83e-05 | 20 |
| GO:007135714 | Thyroid | ATC | cellular response to type I interferon | 33/6293 | 52/18723 | 1.01e-05 | 1.00e-04 | 33 |
| GO:006033714 | Thyroid | ATC | type I interferon signaling pathway | 32/6293 | 50/18723 | 1.06e-05 | 1.05e-04 | 32 |
| GO:000283123 | Thyroid | ATC | regulation of response to biotic stimulus | 144/6293 | 327/18723 | 4.94e-05 | 3.91e-04 | 144 |
| GO:003952815 | Thyroid | ATC | cytoplasmic pattern recognition receptor signaling pathway in response to virus | 23/6293 | 34/18723 | 5.15e-05 | 3.99e-04 | 23 |
| GO:000275315 | Thyroid | ATC | cytoplasmic pattern recognition receptor signaling pathway | 35/6293 | 60/18723 | 7.31e-05 | 5.56e-04 | 35 |
| GO:003424923 | Thyroid | ATC | negative regulation of cellular amide metabolic process | 121/6293 | 273/18723 | 1.36e-04 | 9.57e-04 | 121 |
| GO:006076012 | Thyroid | ATC | positive regulation of response to cytokine stimulus | 33/6293 | 57/18723 | 1.43e-04 | 9.91e-04 | 33 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| LSM14A | SNV | Missense_Mutation | c.1180N>A | p.Glu394Lys | p.E394K | Q8ND56 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| LSM14A | deletion | In_Frame_Del | novel | c.104_118delCCGTAGCCCTTGCCA | p.Thr35_Ala39del | p.T35_A39del | Q8ND56 | protein_coding | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | ||
| LSM14A | SNV | Missense_Mutation | novel | c.1345N>C | p.Glu449Gln | p.E449Q | Q8ND56 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.584) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
| LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| LSM14A | SNV | Missense_Mutation | novel | c.1312C>T | p.Arg438Cys | p.R438C | Q8ND56 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.648) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| LSM14A | SNV | Missense_Mutation | c.580N>G | p.Thr194Ala | p.T194A | Q8ND56 | protein_coding | tolerated(0.1) | benign(0.083) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
| LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| LSM14A | SNV | Missense_Mutation | rs377088182 | c.158N>A | p.Arg53His | p.R53H | Q8ND56 | protein_coding | tolerated(0.05) | possibly_damaging(0.76) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
| LSM14A | SNV | Missense_Mutation | c.526C>A | p.Gln176Lys | p.Q176K | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.392) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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