Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/GADD45A_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/GADD45A_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/GADD45A_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GADD45A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/GADD45A_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GADD45A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/GADD45A_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GADD45A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/GADD45A_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/GADD45A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GADD45A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00182095 | Lung | IAC | peptidyl-serine modification | 70/2061 | 338/18723 | 1.23e-07 | 1.10e-05 | 70 |
GO:00514037 | Lung | IAC | stress-activated MAPK cascade | 54/2061 | 239/18723 | 1.86e-07 | 1.56e-05 | 54 |
GO:00072544 | Lung | IAC | JNK cascade | 42/2061 | 167/18723 | 1.99e-07 | 1.62e-05 | 42 |
GO:00714796 | Lung | IAC | cellular response to ionizing radiation | 24/2061 | 72/18723 | 3.60e-07 | 2.57e-05 | 24 |
GO:00719006 | Lung | IAC | regulation of protein serine/threonine kinase activity | 71/2061 | 359/18723 | 6.33e-07 | 3.72e-05 | 71 |
GO:00703026 | Lung | IAC | regulation of stress-activated protein kinase signaling cascade | 45/2061 | 195/18723 | 1.03e-06 | 5.65e-05 | 45 |
GO:00423268 | Lung | IAC | negative regulation of phosphorylation | 74/2061 | 385/18723 | 1.15e-06 | 6.18e-05 | 74 |
GO:00463284 | Lung | IAC | regulation of JNK cascade | 34/2061 | 133/18723 | 1.88e-06 | 8.87e-05 | 34 |
GO:00380663 | Lung | IAC | p38MAPK cascade | 19/2061 | 55/18723 | 3.20e-06 | 1.38e-04 | 19 |
GO:00019338 | Lung | IAC | negative regulation of protein phosphorylation | 66/2061 | 342/18723 | 3.72e-06 | 1.55e-04 | 66 |
GO:00328726 | Lung | IAC | regulation of stress-activated MAPK cascade | 43/2061 | 192/18723 | 4.06e-06 | 1.66e-04 | 43 |
GO:00901328 | Lung | IAC | epithelium migration | 66/2061 | 360/18723 | 2.12e-05 | 5.97e-04 | 66 |
GO:00714968 | Lung | IAC | cellular response to external stimulus | 60/2061 | 320/18723 | 2.50e-05 | 6.76e-04 | 60 |
GO:00106318 | Lung | IAC | epithelial cell migration | 65/2061 | 357/18723 | 3.05e-05 | 7.82e-04 | 65 |
GO:00513488 | Lung | IAC | negative regulation of transferase activity | 52/2061 | 268/18723 | 3.30e-05 | 8.29e-04 | 52 |
GO:00901308 | Lung | IAC | tissue migration | 66/2061 | 365/18723 | 3.32e-05 | 8.30e-04 | 66 |
GO:00106328 | Lung | IAC | regulation of epithelial cell migration | 55/2061 | 292/18723 | 4.68e-05 | 1.08e-03 | 55 |
GO:00016677 | Lung | IAC | ameboidal-type cell migration | 80/2061 | 475/18723 | 6.90e-05 | 1.47e-03 | 80 |
GO:00093147 | Lung | IAC | response to radiation | 77/2061 | 456/18723 | 8.59e-05 | 1.74e-03 | 77 |
GO:1900744 | Lung | IAC | regulation of p38MAPK cascade | 15/2061 | 47/18723 | 9.77e-05 | 1.93e-03 | 15 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GADD45A | SNV | Missense_Mutation | rs374796115 | c.493N>T | p.Arg165Trp | p.R165W | P24522 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | novel | c.395C>T | p.Ser132Leu | p.S132L | P24522 | protein_coding | tolerated(0.18) | benign(0) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | novel | c.448N>G | p.Ser150Gly | p.S150G | P24522 | protein_coding | deleterious(0) | benign(0.328) | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | novel | c.63N>A | p.Asp21Glu | p.D21E | P24522 | protein_coding | tolerated(0.52) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GADD45A | SNV | Missense_Mutation | novel | c.53N>C | p.Lys18Thr | p.K18T | P24522 | protein_coding | tolerated(0.93) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45A | insertion | In_Frame_Ins | novel | c.64_65insCCCTGGAGGAAGTGCTCAGCA | p.Ser28_Lys29insThrLeuGluGluValLeuSer | p.S28_K29insTLEEVLS | P24522 | protein_coding | | | TCGA-AJ-A3EM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | | c.473C>T | p.Pro158Leu | p.P158L | P24522 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-6147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45A | SNV | Missense_Mutation | | c.338G>T | p.Ser113Ile | p.S113I | P24522 | protein_coding | tolerated(0.07) | benign(0.014) | TCGA-97-8547-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | CR |
GADD45A | SNV | Missense_Mutation | | c.344N>T | p.Gly115Val | p.G115V | P24522 | protein_coding | deleterious(0.03) | benign(0.056) | TCGA-66-2782-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unspecific | | PD |
GADD45A | insertion | In_Frame_Ins | novel | c.408_409insGATCCT | p.Asp137_Pro138dup | p.D137_P138dup | P24522 | protein_coding | | | TCGA-63-A5MT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | DOXORUBICIN | DOXORUBICIN | 7729953 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | WORTMANNIN | WORTMANNIN | 12066222 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | CISPLATIN | CISPLATIN | 9013707,10779360 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | CHELATORS | | 10397746 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | TROGLITAZONE | TROGLITAZONE | 15064713 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | GENISTEIN | GENISTEIN | 15527761 |
1647 | GADD45A | DNA REPAIR, TUMOR SUPPRESSOR, KINASE | | NB1011 | | 12477050 |