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Gene: EIF3H |
Gene summary for EIF3H |
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Gene information | Species | Human | Gene symbol | EIF3H | Gene ID | 8667 |
Gene name | eukaryotic translation initiation factor 3 subunit H | |
Gene Alias | EIF3S3 | |
Cytomap | 8q23.3-q24.11 | |
Gene Type | protein-coding | GO ID | GO:0001732 | UniProtAcc | O15372 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8667 | EIF3H | GSM4909281 | Human | Breast | IDC | 8.81e-26 | 4.78e-01 | 0.21 |
8667 | EIF3H | GSM4909282 | Human | Breast | IDC | 1.96e-03 | 1.85e-01 | -0.0288 |
8667 | EIF3H | GSM4909285 | Human | Breast | IDC | 1.18e-36 | 5.55e-01 | 0.21 |
8667 | EIF3H | GSM4909286 | Human | Breast | IDC | 1.35e-29 | 5.27e-01 | 0.1081 |
8667 | EIF3H | GSM4909288 | Human | Breast | IDC | 2.51e-03 | -1.30e-01 | 0.0988 |
8667 | EIF3H | GSM4909290 | Human | Breast | IDC | 4.64e-65 | 7.72e-01 | 0.2096 |
8667 | EIF3H | GSM4909291 | Human | Breast | IDC | 5.82e-16 | 3.93e-01 | 0.1753 |
8667 | EIF3H | GSM4909294 | Human | Breast | IDC | 1.33e-13 | 1.72e-02 | 0.2022 |
8667 | EIF3H | GSM4909296 | Human | Breast | IDC | 1.80e-34 | 3.66e-01 | 0.1524 |
8667 | EIF3H | GSM4909297 | Human | Breast | IDC | 2.48e-32 | -2.23e-01 | 0.1517 |
8667 | EIF3H | GSM4909301 | Human | Breast | IDC | 2.25e-22 | -5.47e-01 | 0.1577 |
8667 | EIF3H | GSM4909305 | Human | Breast | IDC | 2.13e-09 | 3.80e-01 | 0.0436 |
8667 | EIF3H | GSM4909306 | Human | Breast | IDC | 6.40e-09 | 3.12e-01 | 0.1564 |
8667 | EIF3H | GSM4909307 | Human | Breast | IDC | 5.68e-33 | 5.15e-01 | 0.1569 |
8667 | EIF3H | GSM4909308 | Human | Breast | IDC | 1.07e-104 | 8.68e-01 | 0.158 |
8667 | EIF3H | GSM4909309 | Human | Breast | IDC | 3.16e-07 | -9.62e-02 | 0.0483 |
8667 | EIF3H | GSM4909311 | Human | Breast | IDC | 2.50e-59 | 7.91e-02 | 0.1534 |
8667 | EIF3H | GSM4909312 | Human | Breast | IDC | 1.70e-107 | 9.46e-01 | 0.1552 |
8667 | EIF3H | GSM4909313 | Human | Breast | IDC | 2.72e-04 | -1.84e-02 | 0.0391 |
8667 | EIF3H | GSM4909315 | Human | Breast | IDC | 8.24e-32 | 4.37e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
GO:004217612 | Liver | Cirrhotic | regulation of protein catabolic process | 181/4634 | 391/18723 | 7.94e-21 | 2.77e-18 | 181 |
GO:000641312 | Liver | Cirrhotic | translational initiation | 76/4634 | 118/18723 | 8.36e-20 | 2.18e-17 | 76 |
GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
GO:007182612 | Liver | Cirrhotic | ribonucleoprotein complex subunit organization | 115/4634 | 227/18723 | 2.67e-17 | 3.63e-15 | 115 |
GO:002261812 | Liver | Cirrhotic | ribonucleoprotein complex assembly | 112/4634 | 220/18723 | 4.35e-17 | 5.81e-15 | 112 |
GO:190336212 | Liver | Cirrhotic | regulation of cellular protein catabolic process | 124/4634 | 255/18723 | 9.85e-17 | 1.26e-14 | 124 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
GO:190305012 | Liver | Cirrhotic | regulation of proteolysis involved in cellular protein catabolic process | 103/4634 | 221/18723 | 1.14e-12 | 8.61e-11 | 103 |
GO:200005812 | Liver | Cirrhotic | regulation of ubiquitin-dependent protein catabolic process | 81/4634 | 164/18723 | 7.22e-12 | 4.92e-10 | 81 |
GO:000644612 | Liver | Cirrhotic | regulation of translational initiation | 48/4634 | 79/18723 | 1.14e-11 | 7.14e-10 | 48 |
GO:000218312 | Liver | Cirrhotic | cytoplasmic translational initiation | 26/4634 | 34/18723 | 3.38e-10 | 1.63e-08 | 26 |
GO:006113612 | Liver | Cirrhotic | regulation of proteasomal protein catabolic process | 84/4634 | 187/18723 | 1.28e-09 | 5.56e-08 | 84 |
GO:004586112 | Liver | Cirrhotic | negative regulation of proteolysis | 136/4634 | 351/18723 | 3.46e-09 | 1.42e-07 | 136 |
GO:003243412 | Liver | Cirrhotic | regulation of proteasomal ubiquitin-dependent protein catabolic process | 64/4634 | 134/18723 | 6.16e-09 | 2.40e-07 | 64 |
GO:000989512 | Liver | Cirrhotic | negative regulation of catabolic process | 121/4634 | 320/18723 | 1.21e-07 | 3.39e-06 | 121 |
GO:003133012 | Liver | Cirrhotic | negative regulation of cellular catabolic process | 101/4634 | 262/18723 | 4.57e-07 | 1.05e-05 | 101 |
GO:00017327 | Liver | Cirrhotic | formation of cytoplasmic translation initiation complex | 13/4634 | 16/18723 | 3.31e-06 | 5.74e-05 | 13 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051629 | Esophagus | ESCC | Measles | 90/4205 | 139/8465 | 2.16e-04 | 7.87e-04 | 4.03e-04 | 90 |
hsa0516213 | Esophagus | ESCC | Measles | 90/4205 | 139/8465 | 2.16e-04 | 7.87e-04 | 4.03e-04 | 90 |
hsa051628 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa0516212 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa0516221 | Oral cavity | LP | Measles | 59/2418 | 139/8465 | 2.90e-04 | 1.60e-03 | 1.03e-03 | 59 |
hsa0516231 | Oral cavity | LP | Measles | 59/2418 | 139/8465 | 2.90e-04 | 1.60e-03 | 1.03e-03 | 59 |
hsa0516241 | Oral cavity | EOLP | Measles | 42/1218 | 139/8465 | 1.11e-06 | 9.96e-06 | 5.87e-06 | 42 |
hsa051625 | Oral cavity | EOLP | Measles | 42/1218 | 139/8465 | 1.11e-06 | 9.96e-06 | 5.87e-06 | 42 |
hsa051626 | Oral cavity | NEOLP | Measles | 35/1112 | 139/8465 | 8.30e-05 | 6.14e-04 | 3.86e-04 | 35 |
hsa051627 | Oral cavity | NEOLP | Measles | 35/1112 | 139/8465 | 8.30e-05 | 6.14e-04 | 3.86e-04 | 35 |
hsa051624 | Prostate | BPH | Measles | 42/1718 | 139/8465 | 3.35e-03 | 1.23e-02 | 7.61e-03 | 42 |
hsa0516211 | Prostate | BPH | Measles | 42/1718 | 139/8465 | 3.35e-03 | 1.23e-02 | 7.61e-03 | 42 |
hsa051622 | Prostate | Tumor | Measles | 44/1791 | 139/8465 | 2.33e-03 | 8.85e-03 | 5.49e-03 | 44 |
hsa051623 | Prostate | Tumor | Measles | 44/1791 | 139/8465 | 2.33e-03 | 8.85e-03 | 5.49e-03 | 44 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF3H | SNV | Missense_Mutation | rs765673805 | c.947N>T | p.Ser316Leu | p.S316L | O15372 | protein_coding | deleterious(0.02) | benign(0.062) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EIF3H | SNV | Missense_Mutation | c.685N>A | p.Glu229Lys | p.E229K | O15372 | protein_coding | tolerated(0.27) | benign(0.095) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
EIF3H | SNV | Missense_Mutation | novel | c.150N>G | p.Ile50Met | p.I50M | O15372 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
EIF3H | SNV | Missense_Mutation | c.101N>T | p.Ser34Leu | p.S34L | O15372 | protein_coding | tolerated(0.05) | benign(0.034) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EIF3H | SNV | Missense_Mutation | rs776462055 | c.550C>A | p.Pro184Thr | p.P184T | O15372 | protein_coding | tolerated(0.22) | benign(0.039) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EIF3H | SNV | Missense_Mutation | novel | c.766N>A | p.Asp256Asn | p.D256N | O15372 | protein_coding | deleterious(0) | benign(0.042) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF3H | SNV | Missense_Mutation | novel | c.7N>C | p.Ser3Pro | p.S3P | O15372 | protein_coding | deleterious_low_confidence(0.01) | benign(0.027) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
EIF3H | SNV | Missense_Mutation | c.85N>T | p.Gly29Cys | p.G29C | O15372 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EIF3H | SNV | Missense_Mutation | c.314N>A | p.Arg105Gln | p.R105Q | O15372 | protein_coding | deleterious(0.03) | benign(0.266) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EIF3H | SNV | Missense_Mutation | rs367787019 | c.340N>T | p.His114Tyr | p.H114Y | O15372 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A023-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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