Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00427692 | Colorectum | MSI-H | DNA damage response, detection of DNA damage | 6/1319 | 13/18723 | 1.35e-04 | 3.98e-03 | 6 |
GO:00423263 | Colorectum | MSI-H | negative regulation of phosphorylation | 45/1319 | 385/18723 | 5.71e-04 | 1.14e-02 | 45 |
GO:00485453 | Colorectum | MSI-H | response to steroid hormone | 40/1319 | 339/18723 | 9.37e-04 | 1.64e-02 | 40 |
GO:00019333 | Colorectum | MSI-H | negative regulation of protein phosphorylation | 40/1319 | 342/18723 | 1.11e-03 | 1.86e-02 | 40 |
GO:0009408 | Colorectum | MSI-H | response to heat | 17/1319 | 110/18723 | 1.74e-03 | 2.52e-02 | 17 |
GO:00434013 | Colorectum | MSI-H | steroid hormone mediated signaling pathway | 19/1319 | 136/18723 | 3.19e-03 | 3.93e-02 | 19 |
GO:00097553 | Colorectum | MSI-H | hormone-mediated signaling pathway | 24/1319 | 190/18723 | 3.88e-03 | 4.51e-02 | 24 |
GO:00434093 | Colorectum | MSI-H | negative regulation of MAPK cascade | 23/1319 | 180/18723 | 4.02e-03 | 4.63e-02 | 23 |
GO:00713834 | Colorectum | CRC | cellular response to steroid hormone stimulus | 51/2078 | 204/18723 | 1.67e-08 | 2.79e-06 | 51 |
GO:00305224 | Colorectum | CRC | intracellular receptor signaling pathway | 61/2078 | 265/18723 | 2.00e-08 | 3.23e-06 | 61 |
GO:00434015 | Colorectum | CRC | steroid hormone mediated signaling pathway | 37/2078 | 136/18723 | 1.52e-07 | 1.66e-05 | 37 |
GO:00097555 | Colorectum | CRC | hormone-mediated signaling pathway | 46/2078 | 190/18723 | 2.28e-07 | 2.27e-05 | 46 |
GO:00305184 | Colorectum | CRC | intracellular steroid hormone receptor signaling pathway | 32/2078 | 116/18723 | 7.37e-07 | 4.79e-05 | 32 |
GO:00485455 | Colorectum | CRC | response to steroid hormone | 67/2078 | 339/18723 | 1.77e-06 | 8.92e-05 | 67 |
GO:19033205 | Colorectum | CRC | regulation of protein modification by small protein conjugation or removal | 51/2078 | 242/18723 | 4.55e-06 | 1.87e-04 | 51 |
GO:00313975 | Colorectum | CRC | negative regulation of protein ubiquitination | 24/2078 | 83/18723 | 7.18e-06 | 2.67e-04 | 24 |
GO:00310984 | Colorectum | CRC | stress-activated protein kinase signaling cascade | 51/2078 | 247/18723 | 8.35e-06 | 3.00e-04 | 51 |
GO:19033215 | Colorectum | CRC | negative regulation of protein modification by small protein conjugation or removal | 26/2078 | 95/18723 | 9.16e-06 | 3.19e-04 | 26 |
GO:00971935 | Colorectum | CRC | intrinsic apoptotic signaling pathway | 57/2078 | 288/18723 | 9.77e-06 | 3.31e-04 | 57 |
GO:00305214 | Colorectum | CRC | androgen receptor signaling pathway | 16/2078 | 44/18723 | 9.94e-06 | 3.31e-04 | 16 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0414125 | Cervix | HSIL_HPV | Protein processing in endoplasmic reticulum | 21/459 | 174/8465 | 4.54e-04 | 3.80e-03 | 3.07e-03 | 21 |
hsa0414135 | Cervix | HSIL_HPV | Protein processing in endoplasmic reticulum | 21/459 | 174/8465 | 4.54e-04 | 3.80e-03 | 3.07e-03 | 21 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041416 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa041417 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |