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Gene: DMAP1 |
Gene summary for DMAP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DMAP1 | Gene ID | 55929 |
Gene name | DNA methyltransferase 1 associated protein 1 | |
Gene Alias | DNMAP1 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NPF5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55929 | DMAP1 | LZE4T | Human | Esophagus | ESCC | 8.31e-10 | 1.57e-01 | 0.0811 |
55929 | DMAP1 | LZE7T | Human | Esophagus | ESCC | 4.38e-11 | 5.03e-01 | 0.0667 |
55929 | DMAP1 | LZE8T | Human | Esophagus | ESCC | 6.34e-04 | 9.18e-02 | 0.067 |
55929 | DMAP1 | LZE20T | Human | Esophagus | ESCC | 1.99e-03 | 1.86e-01 | 0.0662 |
55929 | DMAP1 | LZE21D1 | Human | Esophagus | HGIN | 2.40e-03 | 1.88e-01 | 0.0632 |
55929 | DMAP1 | LZE22T | Human | Esophagus | ESCC | 4.53e-06 | 3.90e-01 | 0.068 |
55929 | DMAP1 | LZE24T | Human | Esophagus | ESCC | 2.82e-17 | 3.98e-01 | 0.0596 |
55929 | DMAP1 | LZE6T | Human | Esophagus | ESCC | 1.08e-04 | 1.13e-01 | 0.0845 |
55929 | DMAP1 | P1T-E | Human | Esophagus | ESCC | 1.41e-07 | 3.07e-01 | 0.0875 |
55929 | DMAP1 | P2T-E | Human | Esophagus | ESCC | 3.65e-32 | 5.23e-01 | 0.1177 |
55929 | DMAP1 | P4T-E | Human | Esophagus | ESCC | 2.38e-14 | 2.53e-01 | 0.1323 |
55929 | DMAP1 | P5T-E | Human | Esophagus | ESCC | 8.37e-08 | 2.04e-01 | 0.1327 |
55929 | DMAP1 | P8T-E | Human | Esophagus | ESCC | 8.67e-28 | 3.57e-01 | 0.0889 |
55929 | DMAP1 | P9T-E | Human | Esophagus | ESCC | 7.25e-16 | 1.78e-01 | 0.1131 |
55929 | DMAP1 | P10T-E | Human | Esophagus | ESCC | 4.31e-35 | 4.57e-01 | 0.116 |
55929 | DMAP1 | P11T-E | Human | Esophagus | ESCC | 1.04e-07 | 3.78e-01 | 0.1426 |
55929 | DMAP1 | P12T-E | Human | Esophagus | ESCC | 7.29e-21 | 3.05e-01 | 0.1122 |
55929 | DMAP1 | P15T-E | Human | Esophagus | ESCC | 7.62e-14 | 2.81e-01 | 0.1149 |
55929 | DMAP1 | P16T-E | Human | Esophagus | ESCC | 2.10e-18 | 2.51e-01 | 0.1153 |
55929 | DMAP1 | P17T-E | Human | Esophagus | ESCC | 7.47e-09 | 3.81e-01 | 0.1278 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003225911 | Thyroid | ATC | methylation | 148/6293 | 364/18723 | 2.69e-03 | 1.23e-02 | 148 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMAP1 | SNV | Missense_Mutation | novel | c.853G>A | p.Glu285Lys | p.E285K | Q9NPF5 | protein_coding | tolerated(0.31) | benign(0.333) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
DMAP1 | deletion | Frame_Shift_Del | novel | c.1016delA | p.Lys339ArgfsTer14 | p.K339Rfs*14 | Q9NPF5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
DMAP1 | SNV | Missense_Mutation | c.807N>C | p.Gln269His | p.Q269H | Q9NPF5 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
DMAP1 | SNV | Missense_Mutation | novel | c.448N>C | p.Asp150His | p.D150H | Q9NPF5 | protein_coding | deleterious(0.01) | possibly_damaging(0.737) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
DMAP1 | SNV | Missense_Mutation | c.904C>G | p.Pro302Ala | p.P302A | Q9NPF5 | protein_coding | tolerated(0.42) | benign(0.023) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DMAP1 | SNV | Missense_Mutation | c.70N>T | p.Thr24Ser | p.T24S | Q9NPF5 | protein_coding | tolerated(0.72) | benign(0.005) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
DMAP1 | SNV | Missense_Mutation | c.402N>T | p.Gln134His | p.Q134H | Q9NPF5 | protein_coding | tolerated(0.13) | benign(0.013) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
DMAP1 | SNV | Missense_Mutation | novel | c.1126G>A | p.Glu376Lys | p.E376K | Q9NPF5 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DMAP1 | SNV | Missense_Mutation | rs767182825 | c.1103G>A | p.Arg368Gln | p.R368Q | Q9NPF5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DMAP1 | SNV | Missense_Mutation | rs767182825 | c.1103G>A | p.Arg368Gln | p.R368Q | Q9NPF5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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