![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CCT5 |
Gene summary for CCT5 |
![]() |
Gene information | Species | Human | Gene symbol | CCT5 | Gene ID | 22948 |
Gene name | chaperonin containing TCP1 subunit 5 | |
Gene Alias | CCT-epsilon | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DX08 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22948 | CCT5 | GSM4909282 | Human | Breast | IDC | 2.85e-20 | 5.90e-01 | -0.0288 |
22948 | CCT5 | GSM4909285 | Human | Breast | IDC | 4.43e-23 | 6.30e-01 | 0.21 |
22948 | CCT5 | GSM4909286 | Human | Breast | IDC | 1.57e-03 | -6.90e-02 | 0.1081 |
22948 | CCT5 | GSM4909288 | Human | Breast | IDC | 3.72e-04 | 3.12e-01 | 0.0988 |
22948 | CCT5 | GSM4909293 | Human | Breast | IDC | 9.82e-03 | -1.12e-01 | 0.1581 |
22948 | CCT5 | GSM4909296 | Human | Breast | IDC | 2.19e-11 | -3.38e-01 | 0.1524 |
22948 | CCT5 | GSM4909297 | Human | Breast | IDC | 3.63e-07 | -8.96e-02 | 0.1517 |
22948 | CCT5 | GSM4909301 | Human | Breast | IDC | 2.05e-04 | -2.72e-01 | 0.1577 |
22948 | CCT5 | GSM4909307 | Human | Breast | IDC | 6.30e-06 | -2.84e-01 | 0.1569 |
22948 | CCT5 | GSM4909311 | Human | Breast | IDC | 1.89e-25 | -2.72e-01 | 0.1534 |
22948 | CCT5 | GSM4909312 | Human | Breast | IDC | 1.01e-06 | -4.73e-02 | 0.1552 |
22948 | CCT5 | GSM4909313 | Human | Breast | IDC | 6.29e-05 | -2.99e-01 | 0.0391 |
22948 | CCT5 | GSM4909318 | Human | Breast | IDC | 3.11e-09 | 7.13e-01 | 0.2031 |
22948 | CCT5 | GSM4909319 | Human | Breast | IDC | 8.51e-27 | -3.80e-01 | 0.1563 |
22948 | CCT5 | GSM4909320 | Human | Breast | IDC | 1.30e-02 | -3.16e-01 | 0.1575 |
22948 | CCT5 | GSM4909321 | Human | Breast | IDC | 9.26e-09 | -1.47e-01 | 0.1559 |
22948 | CCT5 | brca1 | Human | Breast | Precancer | 8.88e-31 | 6.44e-01 | -0.0338 |
22948 | CCT5 | brca2 | Human | Breast | Precancer | 2.36e-11 | 4.02e-01 | -0.024 |
22948 | CCT5 | brca3 | Human | Breast | Precancer | 4.68e-05 | 3.82e-01 | -0.0263 |
22948 | CCT5 | M2 | Human | Breast | IDC | 1.03e-18 | 7.91e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190435611 | Liver | Cirrhotic | regulation of telomere maintenance via telomere lengthening | 28/4634 | 61/18723 | 2.59e-04 | 2.31e-03 | 28 |
GO:00322103 | Liver | Cirrhotic | regulation of telomere maintenance via telomerase | 25/4634 | 53/18723 | 3.24e-04 | 2.81e-03 | 25 |
GO:00322002 | Liver | Cirrhotic | telomere organization | 58/4634 | 159/18723 | 6.31e-04 | 4.82e-03 | 58 |
GO:005105211 | Liver | Cirrhotic | regulation of DNA metabolic process | 114/4634 | 359/18723 | 1.48e-03 | 9.85e-03 | 114 |
GO:0034502 | Liver | Cirrhotic | protein localization to chromosome | 36/4634 | 92/18723 | 1.58e-03 | 1.03e-02 | 36 |
GO:20005737 | Liver | Cirrhotic | positive regulation of DNA biosynthetic process | 27/4634 | 66/18723 | 2.78e-03 | 1.62e-02 | 27 |
GO:20002787 | Liver | Cirrhotic | regulation of DNA biosynthetic process | 39/4634 | 106/18723 | 3.80e-03 | 2.08e-02 | 39 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:190382922 | Liver | HCC | positive regulation of cellular protein localization | 199/7958 | 276/18723 | 1.15e-23 | 2.62e-21 | 199 |
GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:000640321 | Liver | HCC | RNA localization | 151/7958 | 201/18723 | 3.72e-21 | 5.89e-19 | 151 |
GO:005082122 | Liver | HCC | protein stabilization | 139/7958 | 191/18723 | 1.61e-17 | 1.71e-15 | 139 |
GO:003450421 | Liver | HCC | protein localization to nucleus | 194/7958 | 290/18723 | 2.84e-17 | 2.85e-15 | 194 |
GO:190495122 | Liver | HCC | positive regulation of establishment of protein localization | 207/7958 | 319/18723 | 3.95e-16 | 3.29e-14 | 207 |
GO:003304421 | Liver | HCC | regulation of chromosome organization | 125/7958 | 187/18723 | 1.35e-11 | 5.40e-10 | 125 |
GO:190018212 | Liver | HCC | positive regulation of protein localization to nucleus | 67/7958 | 87/18723 | 5.43e-11 | 2.00e-09 | 67 |
GO:190018012 | Liver | HCC | regulation of protein localization to nucleus | 95/7958 | 136/18723 | 9.26e-11 | 3.26e-09 | 95 |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:000072311 | Liver | HCC | telomere maintenance | 85/7958 | 131/18723 | 1.86e-07 | 3.40e-06 | 85 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT5 | SNV | Missense_Mutation | rs762786367 | c.1046N>T | p.Thr349Ile | p.T349I | P48643 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
CCT5 | SNV | Missense_Mutation | c.1031G>T | p.Arg344Met | p.R344M | P48643 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCT5 | SNV | Missense_Mutation | c.1018C>T | p.Arg340Trp | p.R340W | P48643 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CCT5 | SNV | Missense_Mutation | c.1018N>T | p.Arg340Trp | p.R340W | P48643 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
CCT5 | SNV | Missense_Mutation | rs768768696 | c.1006G>A | p.Ala336Thr | p.A336T | P48643 | protein_coding | tolerated(0.07) | benign(0.325) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT5 | SNV | Missense_Mutation | novel | c.359N>T | p.Ala120Val | p.A120V | P48643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CCT5 | SNV | Missense_Mutation | rs768768696 | c.1006N>A | p.Ala336Thr | p.A336T | P48643 | protein_coding | tolerated(0.07) | benign(0.325) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CCT5 | SNV | Missense_Mutation | c.338N>A | p.Ala113Asp | p.A113D | P48643 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CCT5 | SNV | Missense_Mutation | novel | c.819N>G | p.Asp273Glu | p.D273E | P48643 | protein_coding | tolerated(1) | benign(0.019) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CCT5 | SNV | Missense_Mutation | c.1400N>A | p.Gly467Asp | p.G467D | P48643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |