Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CAPN2_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/CAPN2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CAPN2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CAPN2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CAPN2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAPN2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAPN2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CAPN2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAPN2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAPN2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CAPN2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CAPN2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697913 | Lung | AIS | response to oxidative stress | 75/1849 | 446/18723 | 2.97e-06 | 1.60e-04 | 75 |
GO:000170112 | Lung | AIS | in utero embryonic development | 59/1849 | 367/18723 | 1.20e-04 | 2.75e-03 | 59 |
GO:007099713 | Lung | AIS | neuron death | 58/1849 | 361/18723 | 1.39e-04 | 3.05e-03 | 58 |
GO:003629313 | Lung | AIS | response to decreased oxygen levels | 53/1849 | 322/18723 | 1.42e-04 | 3.09e-03 | 53 |
GO:000166613 | Lung | AIS | response to hypoxia | 50/1849 | 307/18723 | 2.79e-04 | 5.26e-03 | 50 |
GO:007048213 | Lung | AIS | response to oxygen levels | 54/1849 | 347/18723 | 5.15e-04 | 8.38e-03 | 54 |
GO:190121413 | Lung | AIS | regulation of neuron death | 50/1849 | 319/18723 | 6.90e-04 | 1.02e-02 | 50 |
GO:00426921 | Lung | AIS | muscle cell differentiation | 58/1849 | 384/18723 | 7.00e-04 | 1.03e-02 | 58 |
GO:190121613 | Lung | AIS | positive regulation of neuron death | 20/1849 | 97/18723 | 1.12e-03 | 1.44e-02 | 20 |
GO:01501721 | Lung | AIS | regulation of phosphatidylcholine metabolic process | 5/1849 | 10/18723 | 1.54e-03 | 1.82e-02 | 5 |
GO:000030213 | Lung | AIS | response to reactive oxygen species | 35/1849 | 222/18723 | 3.69e-03 | 3.46e-02 | 35 |
GO:00511461 | Lung | AIS | striated muscle cell differentiation | 42/1849 | 283/18723 | 4.88e-03 | 4.24e-02 | 42 |
GO:00464701 | Lung | AIS | phosphatidylcholine metabolic process | 15/1849 | 74/18723 | 5.25e-03 | 4.49e-02 | 15 |
GO:01501722 | Lung | AAH | regulation of phosphatidylcholine metabolic process | 4/613 | 10/18723 | 2.04e-04 | 1.13e-02 | 4 |
GO:000170121 | Lung | AAH | in utero embryonic development | 24/613 | 367/18723 | 1.09e-03 | 3.25e-02 | 24 |
GO:00426922 | Lung | MIAC | muscle cell differentiation | 39/967 | 384/18723 | 4.51e-05 | 2.36e-03 | 39 |
GO:000697923 | Lung | MIAC | response to oxidative stress | 43/967 | 446/18723 | 6.39e-05 | 3.12e-03 | 43 |
GO:0007520 | Lung | MIAC | myoblast fusion | 8/967 | 42/18723 | 1.21e-03 | 2.30e-02 | 8 |
GO:000166622 | Lung | MIAC | response to hypoxia | 29/967 | 307/18723 | 1.30e-03 | 2.42e-02 | 29 |
GO:003629322 | Lung | MIAC | response to decreased oxygen levels | 30/967 | 322/18723 | 1.35e-03 | 2.48e-02 | 30 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPN2 | SNV | Missense_Mutation | | c.1121N>A | p.Cys374Tyr | p.C374Y | P17655 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN2 | SNV | Missense_Mutation | rs550161035 | c.2003N>A | p.Arg668Gln | p.R668Q | P17655 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPN2 | SNV | Missense_Mutation | rs368366230 | c.1192N>A | p.Glu398Lys | p.E398K | P17655 | protein_coding | tolerated(0.21) | benign(0.043) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
CAPN2 | SNV | Missense_Mutation | novel | c.754G>A | p.Ala252Thr | p.A252T | P17655 | protein_coding | tolerated(0.14) | benign(0.302) | TCGA-AC-A2BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN2 | SNV | Missense_Mutation | | c.564N>G | p.Ile188Met | p.I188M | P17655 | protein_coding | deleterious(0.02) | benign(0.059) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
CAPN2 | SNV | Missense_Mutation | novel | c.2059N>G | p.Ile687Val | p.I687V | P17655 | protein_coding | tolerated(0.5) | benign(0.014) | TCGA-S3-A6ZG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
CAPN2 | insertion | Nonsense_Mutation | novel | c.594_595insACTTGAGAAGGA | p.Gly198_Ala199insThrTerGluGly | p.G198_A199insT*EG | P17655 | protein_coding | | | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CAPN2 | insertion | Nonsense_Mutation | novel | c.596_597insTCTACTTCCTTGACAGGACACATTTGTAT | p.Thr200LeufsTer4 | p.T200Lfs*4 | P17655 | protein_coding | | | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CAPN2 | insertion | Nonsense_Mutation | novel | c.680_681insACCGCGCCCGGCCTGAGATTTTCTTTAAAACA | p.Ile228ProfsTer5 | p.I228Pfs*5 | P17655 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAPN2 | deletion | Frame_Shift_Del | novel | c.1601delT | p.Phe534SerfsTer24 | p.F534Sfs*24 | P17655 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | Carboxamide derivative 10 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | Carboxamide derivative 6 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | inhibitor | 252166770 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | Carboxamide derivative 9 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | ABT-957 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | Epoxysuccinate derivative 4 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | Epoxysuccinate derivative 6 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | Epoxysuccinate derivative 3 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | PMID25399719-Compound-17 | | |
824 | CAPN2 | PROTEASE, DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE | | Carboxamide derivative 7 | | |