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Gene: AK3 |
Gene summary for AK3 |
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Gene information | Species | Human | Gene symbol | AK3 | Gene ID | 50808 |
Gene name | adenylate kinase 3 | |
Gene Alias | AK3L1 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7Z4Y4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50808 | AK3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.56e-10 | -4.96e-01 | 0.0155 |
50808 | AK3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.84e-12 | 6.58e-01 | -0.1954 |
50808 | AK3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.62e-11 | 9.83e-01 | 0.281 |
50808 | AK3 | A001-C-207 | Human | Colorectum | FAP | 9.64e-03 | -1.41e-01 | 0.1278 |
50808 | AK3 | A015-C-203 | Human | Colorectum | FAP | 5.10e-30 | 1.10e-03 | -0.1294 |
50808 | AK3 | A015-C-204 | Human | Colorectum | FAP | 1.59e-04 | -2.18e-01 | -0.0228 |
50808 | AK3 | A014-C-040 | Human | Colorectum | FAP | 7.34e-05 | -4.12e-01 | -0.1184 |
50808 | AK3 | A002-C-201 | Human | Colorectum | FAP | 6.66e-10 | -1.98e-01 | 0.0324 |
50808 | AK3 | A002-C-203 | Human | Colorectum | FAP | 3.24e-03 | -5.46e-02 | 0.2786 |
50808 | AK3 | A001-C-119 | Human | Colorectum | FAP | 2.55e-04 | -1.54e-01 | -0.1557 |
50808 | AK3 | A001-C-108 | Human | Colorectum | FAP | 1.02e-15 | -1.60e-01 | -0.0272 |
50808 | AK3 | A002-C-205 | Human | Colorectum | FAP | 1.20e-22 | -2.14e-01 | -0.1236 |
50808 | AK3 | A015-C-005 | Human | Colorectum | FAP | 2.74e-02 | -2.10e-01 | -0.0336 |
50808 | AK3 | A015-C-006 | Human | Colorectum | FAP | 4.14e-16 | -2.43e-01 | -0.0994 |
50808 | AK3 | A015-C-106 | Human | Colorectum | FAP | 8.21e-12 | -1.32e-03 | -0.0511 |
50808 | AK3 | A002-C-114 | Human | Colorectum | FAP | 3.65e-18 | -2.23e-01 | -0.1561 |
50808 | AK3 | A015-C-104 | Human | Colorectum | FAP | 6.02e-33 | -3.61e-03 | -0.1899 |
50808 | AK3 | A015-C-202 | Human | Colorectum | FAP | 2.06e-03 | 3.31e-01 | -0.0849 |
50808 | AK3 | A001-C-014 | Human | Colorectum | FAP | 1.12e-14 | -2.71e-01 | 0.0135 |
50808 | AK3 | A002-C-016 | Human | Colorectum | FAP | 2.89e-21 | -2.19e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000916711 | Liver | HCC | purine ribonucleoside monophosphate metabolic process | 28/7958 | 41/18723 | 7.54e-04 | 4.55e-03 | 28 |
GO:00508172 | Liver | HCC | coagulation | 118/7958 | 222/18723 | 8.41e-04 | 5.03e-03 | 118 |
GO:200057312 | Liver | HCC | positive regulation of DNA biosynthetic process | 41/7958 | 66/18723 | 1.02e-03 | 5.86e-03 | 41 |
GO:005087822 | Liver | HCC | regulation of body fluid levels | 191/7958 | 379/18723 | 1.06e-03 | 6.11e-03 | 191 |
GO:00725271 | Liver | HCC | pyrimidine-containing compound metabolic process | 49/7958 | 82/18723 | 1.20e-03 | 6.68e-03 | 49 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:0010976 | Liver | HCC | positive regulation of neuron projection development | 88/7958 | 163/18723 | 1.98e-03 | 1.00e-02 | 88 |
GO:0009147 | Liver | HCC | pyrimidine nucleoside triphosphate metabolic process | 18/7958 | 25/18723 | 2.74e-03 | 1.31e-02 | 18 |
GO:0010762 | Liver | HCC | regulation of fibroblast migration | 24/7958 | 36/18723 | 2.95e-03 | 1.38e-02 | 24 |
GO:00507674 | Liver | HCC | regulation of neurogenesis | 181/7958 | 364/18723 | 3.00e-03 | 1.40e-02 | 181 |
GO:00450881 | Liver | HCC | regulation of innate immune response | 113/7958 | 218/18723 | 3.27e-03 | 1.50e-02 | 113 |
GO:0060999 | Liver | HCC | positive regulation of dendritic spine development | 27/7958 | 42/18723 | 3.60e-03 | 1.60e-02 | 27 |
GO:00092181 | Liver | HCC | pyrimidine ribonucleotide metabolic process | 20/7958 | 29/18723 | 3.61e-03 | 1.60e-02 | 20 |
GO:00507693 | Liver | HCC | positive regulation of neurogenesis | 116/7958 | 225/18723 | 3.67e-03 | 1.63e-02 | 116 |
GO:0002218 | Liver | HCC | activation of innate immune response | 32/7958 | 52/18723 | 4.35e-03 | 1.89e-02 | 32 |
GO:006099611 | Liver | HCC | dendritic spine development | 54/7958 | 99/18723 | 1.03e-02 | 3.86e-02 | 54 |
GO:0050775 | Liver | HCC | positive regulation of dendrite morphogenesis | 23/7958 | 37/18723 | 1.25e-02 | 4.53e-02 | 23 |
GO:001635811 | Liver | HCC | dendrite development | 121/7958 | 243/18723 | 1.26e-02 | 4.56e-02 | 121 |
GO:000166721 | Liver | HCC | ameboidal-type cell migration | 226/7958 | 475/18723 | 1.35e-02 | 4.81e-02 | 226 |
GO:00609981 | Liver | HCC | regulation of dendritic spine development | 35/7958 | 61/18723 | 1.35e-02 | 4.82e-02 | 35 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0124021 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0124031 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AK3 | SNV | Missense_Mutation | novel | c.593G>A | p.Gly198Glu | p.G198E | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
AK3 | SNV | Missense_Mutation | rs773321603 | c.53N>G | p.Ser18Trp | p.S18W | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AK3 | SNV | Missense_Mutation | c.456N>G | p.Asp152Glu | p.D152E | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
AK3 | SNV | Missense_Mutation | novel | c.359T>G | p.Val120Gly | p.V120G | Q9UIJ7 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
AK3 | SNV | Missense_Mutation | c.88C>G | p.His30Asp | p.H30D | Q9UIJ7 | protein_coding | tolerated(0.78) | benign(0) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
AK3 | deletion | Frame_Shift_Del | c.7delN | p.Ala3ArgfsTer9 | p.A3Rfs*9 | Q9UIJ7 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
AK3 | deletion | Frame_Shift_Del | c.7delG | p.Ala3ArgfsTer9 | p.A3Rfs*9 | Q9UIJ7 | protein_coding | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |||
AK3 | SNV | Missense_Mutation | novel | c.115N>A | p.Gly39Arg | p.G39R | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AK3 | SNV | Missense_Mutation | rs750035551 | c.370N>T | p.Arg124Cys | p.R124C | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
AK3 | SNV | Missense_Mutation | novel | c.436N>C | p.Lys146Gln | p.K146Q | Q9UIJ7 | protein_coding | tolerated(0.27) | benign(0.106) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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