GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003530321 | Stomach | SIM | regulation of dephosphorylation | 13/708 | 128/18723 | 1.13e-03 | 1.45e-02 | 13 |
GO:001092131 | Stomach | SIM | regulation of phosphatase activity | 10/708 | 84/18723 | 1.24e-03 | 1.56e-02 | 10 |
GO:003103231 | Stomach | SIM | actomyosin structure organization | 17/708 | 196/18723 | 1.28e-03 | 1.59e-02 | 17 |
GO:007132241 | Stomach | SIM | cellular response to carbohydrate stimulus | 15/708 | 163/18723 | 1.35e-03 | 1.66e-02 | 15 |
GO:001092211 | Stomach | SIM | positive regulation of phosphatase activity | 6/708 | 34/18723 | 1.56e-03 | 1.83e-02 | 6 |
GO:190018011 | Stomach | SIM | regulation of protein localization to nucleus | 13/708 | 136/18723 | 1.96e-03 | 2.16e-02 | 13 |
GO:004259331 | Stomach | SIM | glucose homeostasis | 20/708 | 258/18723 | 1.99e-03 | 2.16e-02 | 20 |
GO:003350031 | Stomach | SIM | carbohydrate homeostasis | 20/708 | 259/18723 | 2.08e-03 | 2.23e-02 | 20 |
GO:00507145 | Stomach | SIM | positive regulation of protein secretion | 13/708 | 137/18723 | 2.10e-03 | 2.24e-02 | 13 |
GO:00357741 | Stomach | SIM | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 6/708 | 36/18723 | 2.11e-03 | 2.25e-02 | 6 |
GO:190382931 | Stomach | SIM | positive regulation of cellular protein localization | 20/708 | 276/18723 | 4.29e-03 | 3.81e-02 | 20 |
GO:00515921 | Stomach | SIM | response to calcium ion | 13/708 | 149/18723 | 4.35e-03 | 3.86e-02 | 13 |
GO:190290431 | Stomach | SIM | negative regulation of supramolecular fiber organization | 14/708 | 167/18723 | 4.50e-03 | 3.94e-02 | 14 |
GO:190018211 | Stomach | SIM | positive regulation of protein localization to nucleus | 9/708 | 87/18723 | 5.57e-03 | 4.60e-02 | 9 |
GO:002261330 | Thyroid | HT | ribonucleoprotein complex biogenesis | 74/1272 | 463/18723 | 4.05e-12 | 8.05e-10 | 74 |
GO:005134830 | Thyroid | HT | negative regulation of transferase activity | 45/1272 | 268/18723 | 1.49e-08 | 1.20e-06 | 45 |
GO:004225429 | Thyroid | HT | ribosome biogenesis | 48/1272 | 299/18723 | 2.16e-08 | 1.70e-06 | 48 |
GO:004227329 | Thyroid | HT | ribosomal large subunit biogenesis | 19/1272 | 72/18723 | 2.08e-07 | 1.07e-05 | 19 |
GO:000640325 | Thyroid | HT | RNA localization | 35/1272 | 201/18723 | 2.37e-07 | 1.19e-05 | 35 |
GO:007048227 | Thyroid | HT | response to oxygen levels | 50/1272 | 347/18723 | 3.61e-07 | 1.65e-05 | 50 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HP | SNV | Missense_Mutation | novel | c.593T>A | p.Leu198Gln | p.L198Q | P00738 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HP | insertion | Nonsense_Mutation | novel | c.594_595insTTTTAA | p.Leu198_Thr199insPheTer | p.L198_T199insF* | P00738 | protein_coding | | | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HP | insertion | Frame_Shift_Ins | novel | c.593_594insTCTTGCCCAAATTCAG | p.Thr199LeufsTer9 | p.T199Lfs*9 | P00738 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
HP | insertion | Frame_Shift_Ins | novel | c.125_126insA | p.Tyr43LeufsTer11 | p.Y43Lfs*11 | P00738 | protein_coding | | | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
HP | insertion | In_Frame_Ins | novel | c.127_128insCAGGCA | p.Tyr43delinsSerGlyAsn | p.Y43delinsSGN | P00738 | protein_coding | | | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
HP | SNV | Missense_Mutation | novel | c.218A>C | p.Gln73Pro | p.Q73P | P00738 | protein_coding | tolerated(0.17) | benign(0.278) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HP | SNV | Missense_Mutation | novel | c.1153N>C | p.Glu385Gln | p.E385Q | P00738 | protein_coding | tolerated(0.09) | possibly_damaging(0.624) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
HP | SNV | Missense_Mutation | | c.91G>A | p.Asp31Asn | p.D31N | P00738 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.709) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
HP | SNV | Missense_Mutation | | c.140C>T | p.Ser47Leu | p.S47L | P00738 | protein_coding | tolerated(0.23) | benign(0) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HP | SNV | Missense_Mutation | | c.791N>A | p.Pro264His | p.P264H | P00738 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | | HEPATITIS B VACCINE | | 8256500 |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | | 17 BETA-ESTRADIOL | | 2078644 |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | | PYRIDOXINE | PYRIDOXINE | 6935482 |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | | AT1001 | | 22731712 |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | | STREPTOZOTOCIN | STREPTOZOCIN | 16713232 |
3240 | HP | DRUGGABLE GENOME, PROTEASE, ENZYME | | VACCINE | | 8228935 |