Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: C6

Gene summary for C6

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

C6

Gene ID

729

Gene namecomplement C6
Gene AliasC6
Cytomap5p13.1
Gene Typeprotein-coding
GO ID

GO:0001701

UniProtAcc

P13671


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
729C6NAFLD1HumanLiverNAFLD2.68e-111.17e+00-0.04
729C6S43HumanLiverCirrhotic1.89e-083.61e-02-0.0187
729C6HCC1_MengHumanLiverHCC9.17e-29-5.13e-010.0246
729C6HCC2_MengHumanLiverHCC1.09e-10-5.29e-010.0107
729C6cirrhotic1HumanLiverCirrhotic7.08e-14-3.02e-010.0202
729C6cirrhotic2HumanLiverCirrhotic1.54e-20-1.89e-010.0201
729C6cirrhotic3HumanLiverCirrhotic1.26e-10-2.75e-010.0215
729C6HCC5HumanLiverHCC1.54e-047.50e-010.4932
729C6Pt13.aHumanLiverHCC1.32e-09-4.40e-010.021
729C6Pt13.bHumanLiverHCC4.54e-10-3.65e-010.0251
729C6Pt14.dHumanLiverHCC9.20e-09-4.71e-010.0143
729C6S014HumanLiverHCC2.49e-03-5.07e-010.2254
729C6S015HumanLiverHCC3.42e-03-5.37e-010.2375
729C6S016HumanLiverHCC4.74e-11-5.59e-010.2243
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0016072112ThyroidPTCrRNA metabolic process160/5968236/187235.68e-303.58e-27160
GO:0042176113ThyroidPTCregulation of protein catabolic process231/5968391/187234.76e-292.14e-26231
GO:0072594112ThyroidPTCestablishment of protein localization to organelle244/5968422/187231.18e-284.97e-26244
GO:004819320ThyroidPTCGolgi vesicle transport186/5968296/187233.09e-281.22e-25186
GO:1903311112ThyroidPTCregulation of mRNA metabolic process181/5968288/187231.60e-275.94e-25181
GO:1903362113ThyroidPTCregulation of cellular protein catabolic process162/5968255/187231.62e-255.12e-23162
GO:0034976113ThyroidPTCresponse to endoplasmic reticulum stress161/5968256/187231.14e-243.27e-22161
GO:1903050113ThyroidPTCregulation of proteolysis involved in cellular protein catabolic process140/5968221/187234.63e-221.01e-19140
GO:0006605113ThyroidPTCprotein targeting180/5968314/187236.81e-211.19e-18180
GO:003447018ThyroidPTCncRNA processing215/5968395/187237.14e-211.22e-18215
GO:0045732113ThyroidPTCpositive regulation of protein catabolic process142/5968231/187231.43e-202.38e-18142
GO:0006401112ThyroidPTCRNA catabolic process163/5968278/187232.13e-203.27e-18163
GO:0061136113ThyroidPTCregulation of proteasomal protein catabolic process121/5968187/187232.25e-203.37e-18121
GO:2001233113ThyroidPTCregulation of apoptotic signaling pathway197/5968356/187232.58e-203.69e-18197
GO:0006979113ThyroidPTCresponse to oxidative stress234/5968446/187236.97e-209.77e-18234
GO:0016236110ThyroidPTCmacroautophagy167/5968291/187231.51e-191.91e-17167
GO:1903364113ThyroidPTCpositive regulation of cellular protein catabolic process104/5968155/187231.93e-192.39e-17104
GO:0006402112ThyroidPTCmRNA catabolic process139/5968232/187239.59e-191.12e-16139
GO:0045862113ThyroidPTCpositive regulation of proteolysis198/5968372/187236.68e-186.91e-16198
GO:001657010ThyroidPTChistone modification235/5968463/187231.17e-171.15e-15235
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0517114LiverNAFLDCoronavirus disease - COVID-19111/1043232/84651.01e-413.32e-392.67e-39111
hsa04610LiverNAFLDComplement and coagulation cascades35/104386/84652.48e-112.04e-091.64e-0935
hsa0481010LiverNAFLDRegulation of actin cytoskeleton50/1043229/84653.01e-057.59e-046.11e-0450
hsa0517115LiverNAFLDCoronavirus disease - COVID-19111/1043232/84651.01e-413.32e-392.67e-39111
hsa046101LiverNAFLDComplement and coagulation cascades35/104386/84652.48e-112.04e-091.64e-0935
hsa0481011LiverNAFLDRegulation of actin cytoskeleton50/1043229/84653.01e-057.59e-046.11e-0450
hsa0517122LiverCirrhoticCoronavirus disease - COVID-19136/2530232/84653.28e-201.82e-181.12e-18136
hsa0502014LiverCirrhoticPrion disease152/2530273/84651.84e-198.78e-185.41e-18152
hsa046102LiverCirrhoticComplement and coagulation cascades48/253086/84654.41e-075.44e-063.35e-0648
hsa0481021LiverCirrhoticRegulation of actin cytoskeleton100/2530229/84655.28e-065.50e-053.39e-05100
hsa0517132LiverCirrhoticCoronavirus disease - COVID-19136/2530232/84653.28e-201.82e-181.12e-18136
hsa0502015LiverCirrhoticPrion disease152/2530273/84651.84e-198.78e-185.41e-18152
hsa046103LiverCirrhoticComplement and coagulation cascades48/253086/84654.41e-075.44e-063.35e-0648
hsa0481031LiverCirrhoticRegulation of actin cytoskeleton100/2530229/84655.28e-065.50e-053.39e-05100
hsa0502022LiverHCCPrion disease195/4020273/84653.26e-161.56e-148.67e-15195
hsa0517142LiverHCCCoronavirus disease - COVID-19167/4020232/84651.50e-144.19e-132.33e-13167
hsa046104LiverHCCComplement and coagulation cascades57/402086/84653.19e-041.45e-038.04e-0457
hsa0481041LiverHCCRegulation of actin cytoskeleton134/4020229/84654.48e-041.94e-031.08e-03134
hsa0502032LiverHCCPrion disease195/4020273/84653.26e-161.56e-148.67e-15195
hsa0517152LiverHCCCoronavirus disease - COVID-19167/4020232/84651.50e-144.19e-132.33e-13167
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
C6SNVMissense_Mutationc.201N>Cp.Lys67Asnp.K67NP13671protein_codingtolerated(0.09)possibly_damaging(0.717)TCGA-A8-A07W-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyexemestaneSD
C6SNVMissense_Mutationc.1672G>Ap.Asp558Asnp.D558NP13671protein_codingtolerated(0.09)benign(0.29)TCGA-A8-A09B-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapy5-fluorouracilSD
C6SNVMissense_Mutationc.1375N>Gp.Lys459Glup.K459EP13671protein_codingdeleterious(0)probably_damaging(0.934)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
C6SNVMissense_Mutationrs369381506c.1067N>Ap.Arg356Glnp.R356QP13671protein_codingtolerated(0.17)benign(0.098)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
C6SNVMissense_Mutationrs763860114c.2522G>Ap.Arg841Hisp.R841HP13671protein_codingtolerated(0.19)benign(0.35)TCGA-C8-A12Y-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
C6SNVMissense_Mutationc.311N>Tp.Arg104Ilep.R104IP13671protein_codingdeleterious(0)probably_damaging(0.993)TCGA-E9-A1NA-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
C6SNVMissense_Mutationnovelc.1177N>Ap.Glu393Lysp.E393KP13671protein_codingtolerated(0.24)benign(0.169)TCGA-PE-A5DE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
C6insertionFrame_Shift_Insrs762335076c.828_829insGp.Ser277GlufsTer15p.S277Efs*15P13671protein_codingTCGA-AN-A04C-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
C6deletionFrame_Shift_Delrs372345940c.828delNp.Ser277AlafsTer43p.S277Afs*43P13671protein_codingTCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
C6insertionFrame_Shift_Insrs762335076c.828dupGp.Ser277GlufsTer15p.S277Efs*15P13671protein_codingTCGA-E9-A1NC-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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