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Gene: ZBTB7B |
Gene summary for ZBTB7B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZBTB7B | Gene ID | 51043 |
| Gene name | zinc finger and BTB domain containing 7B | |
| Gene Alias | CKROX | |
| Cytomap | 1q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O15156 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51043 | ZBTB7B | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.48e-06 | 6.39e-01 | 0.0131 |
| 51043 | ZBTB7B | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.59e-06 | 6.76e-01 | -0.0177 |
| 51043 | ZBTB7B | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.85e-16 | 7.16e-01 | 0.0338 |
| 51043 | ZBTB7B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.19e-02 | 2.42e-01 | 0.0674 |
| 51043 | ZBTB7B | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.00e-27 | 1.61e+00 | 0.0112 |
| 51043 | ZBTB7B | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.53e-18 | 1.02e+00 | 0.0588 |
| 51043 | ZBTB7B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.45e-57 | 1.40e+00 | 0.3005 |
| 51043 | ZBTB7B | LZE7T | Human | Esophagus | ESCC | 2.17e-11 | 1.79e-01 | 0.0667 |
| 51043 | ZBTB7B | LZE20T | Human | Esophagus | ESCC | 4.95e-09 | 6.50e-02 | 0.0662 |
| 51043 | ZBTB7B | LZE24T | Human | Esophagus | ESCC | 4.44e-07 | 2.46e-01 | 0.0596 |
| 51043 | ZBTB7B | P1T-E | Human | Esophagus | ESCC | 8.18e-04 | 4.04e-01 | 0.0875 |
| 51043 | ZBTB7B | P2T-E | Human | Esophagus | ESCC | 3.30e-12 | 2.77e-02 | 0.1177 |
| 51043 | ZBTB7B | P4T-E | Human | Esophagus | ESCC | 7.44e-10 | 5.52e-02 | 0.1323 |
| 51043 | ZBTB7B | P5T-E | Human | Esophagus | ESCC | 1.92e-17 | 1.58e-01 | 0.1327 |
| 51043 | ZBTB7B | P8T-E | Human | Esophagus | ESCC | 2.68e-10 | 6.64e-02 | 0.0889 |
| 51043 | ZBTB7B | P9T-E | Human | Esophagus | ESCC | 1.65e-09 | 2.76e-02 | 0.1131 |
| 51043 | ZBTB7B | P10T-E | Human | Esophagus | ESCC | 9.30e-11 | -6.31e-03 | 0.116 |
| 51043 | ZBTB7B | P11T-E | Human | Esophagus | ESCC | 2.17e-03 | 8.62e-02 | 0.1426 |
| 51043 | ZBTB7B | P12T-E | Human | Esophagus | ESCC | 7.17e-09 | 1.32e-01 | 0.1122 |
| 51043 | ZBTB7B | P15T-E | Human | Esophagus | ESCC | 8.10e-13 | 2.35e-01 | 0.1149 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00706631 | Stomach | CAG with IM | regulation of leukocyte proliferation | 27/1050 | 245/18723 | 6.29e-04 | 8.92e-03 | 27 |
| GO:005087811 | Stomach | CAG with IM | regulation of body fluid levels | 37/1050 | 379/18723 | 7.56e-04 | 1.03e-02 | 37 |
| GO:19037071 | Stomach | CAG with IM | negative regulation of hemopoiesis | 15/1050 | 106/18723 | 8.29e-04 | 1.09e-02 | 15 |
| GO:00018191 | Stomach | CAG with IM | positive regulation of cytokine production | 43/1050 | 467/18723 | 9.84e-04 | 1.27e-02 | 43 |
| GO:004343411 | Stomach | CAG with IM | response to peptide hormone | 39/1050 | 414/18723 | 1.09e-03 | 1.33e-02 | 39 |
| GO:00421291 | Stomach | CAG with IM | regulation of T cell proliferation | 20/1050 | 171/18723 | 1.48e-03 | 1.68e-02 | 20 |
| GO:00024601 | Stomach | CAG with IM | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 33/1050 | 356/18723 | 3.26e-03 | 2.99e-02 | 33 |
| GO:00466511 | Stomach | CAG with IM | lymphocyte proliferation | 28/1050 | 288/18723 | 3.33e-03 | 3.03e-02 | 28 |
| GO:0032943 | Stomach | CAG with IM | mononuclear cell proliferation | 28/1050 | 291/18723 | 3.84e-03 | 3.37e-02 | 28 |
| GO:00506701 | Stomach | CAG with IM | regulation of lymphocyte proliferation | 23/1050 | 225/18723 | 4.01e-03 | 3.47e-02 | 23 |
| GO:0032944 | Stomach | CAG with IM | regulation of mononuclear cell proliferation | 23/1050 | 227/18723 | 4.47e-03 | 3.76e-02 | 23 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZBTB7B | MLUM | Breast | IDC | ENC1,FASN,SIM2, etc. | 5.52e-01 |  |
| ZBTB7B | TREG | Cervix | CC | CORO1B,ZNF700,CD40LG, etc. | 1.29e-01 |  |
| ZBTB7B | CD4TN | Cervix | Healthy | CORO1B,ZNF700,CD40LG, etc. | 1.55e-01 |  |
| ZBTB7B | CD8TEXP | Cervix | Healthy | CORO1B,ZNF700,CD40LG, etc. | 1.10e-01 | |
| ZBTB7B | TREG | Cervix | Healthy | CORO1B,ZNF700,CD40LG, etc. | 1.03e-01 | |
| ZBTB7B | TFH | Cervix | Healthy | CORO1B,ZNF700,CD40LG, etc. | 1.24e-01 | |
| ZBTB7B | TREG | Cervix | HSIL_HPV | CORO1B,ZNF700,CD40LG, etc. | 1.07e-01 |  |
| ZBTB7B | TFH | Cervix | HSIL_HPV | CORO1B,ZNF700,CD40LG, etc. | 1.36e-01 | |
| ZBTB7B | CD4TN | Cervix | N_HPV | CORO1B,ZNF700,CD40LG, etc. | 2.56e-01 |  |
| ZBTB7B | TREG | Cervix | N_HPV | CORO1B,ZNF700,CD40LG, etc. | 8.11e-02 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 3 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZBTB7B | SNV | Missense_Mutation | novel | c.1385N>A | p.Arg462Gln | p.R462Q | O15156 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
| ZBTB7B | SNV | Missense_Mutation | c.110N>A | p.Ser37Asn | p.S37N | O15156 | protein_coding | tolerated(0.53) | probably_damaging(0.969) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZBTB7B | SNV | Missense_Mutation | c.1024N>C | p.Asp342His | p.D342H | O15156 | protein_coding | deleterious(0.04) | probably_damaging(0.988) | TCGA-D8-A27I-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adrimycin+cyclophosphamide | SD | |
| ZBTB7B | SNV | Missense_Mutation | c.895N>A | p.Glu299Lys | p.E299K | O15156 | protein_coding | tolerated(0.25) | benign(0.222) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZBTB7B | SNV | Missense_Mutation | c.232G>A | p.Glu78Lys | p.E78K | O15156 | protein_coding | deleterious(0.01) | benign(0.161) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZBTB7B | insertion | In_Frame_Ins | novel | c.690_691insCCCAAA | p.Pro230_Val231insProLys | p.P230_V231insPK | O15156 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
| ZBTB7B | SNV | Missense_Mutation | c.1120N>T | p.Arg374Cys | p.R374C | O15156 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZBTB7B | SNV | Missense_Mutation | c.274T>C | p.Tyr92His | p.Y92H | O15156 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | PD | |
| ZBTB7B | SNV | Missense_Mutation | c.968N>T | p.Gly323Val | p.G323V | O15156 | protein_coding | tolerated(0.07) | probably_damaging(0.977) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
| ZBTB7B | SNV | Missense_Mutation | c.651G>T | p.Gln217His | p.Q217H | O15156 | protein_coding | tolerated(0.39) | probably_damaging(0.923) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 7 8 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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