Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SELE

Gene summary for SELE

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SELE

Gene ID

6401

Gene nameselectin E
Gene AliasCD62E
Cytomap1q24.2
Gene Typeprotein-coding
GO ID

GO:0002090

UniProtAcc

P16581


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6401SELEP2T-EHumanEsophagusESCC2.96e-099.01e-010.1177
6401SELEP38T-EHumanEsophagusESCC3.60e-042.01e-010.127
6401SELEP61T-EHumanEsophagusESCC1.63e-066.22e-020.099
6401SELEP80T-EHumanEsophagusESCC2.02e-025.43e-020.155
6401SELEP127T-EHumanEsophagusESCC7.96e-042.63e-020.0826
6401SELEP128T-EHumanEsophagusESCC5.36e-311.16e+000.1241
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:200124210CervixCCregulation of intrinsic apoptotic signaling pathway52/2311164/187235.06e-111.01e-0852
GO:001049810CervixCCproteasomal protein catabolic process111/2311490/187238.98e-111.58e-08111
GO:002240710CervixCCregulation of cell-cell adhesion103/2311448/187231.78e-102.87e-08103
GO:004578510CervixCCpositive regulation of cell adhesion101/2311437/187231.96e-103.08e-08101
GO:000697910CervixCCresponse to oxidative stress102/2311446/187232.99e-104.36e-08102
GO:00421108CervixCCT cell activation107/2311487/187231.24e-091.46e-07107
GO:00508638CervixCCregulation of T cell activation80/2311329/187231.28e-091.47e-0780
GO:00060919CervixCCgeneration of precursor metabolites and energy105/2311490/187237.40e-096.61e-07105
GO:00071598CervixCCleukocyte cell-cell adhesion85/2311371/187238.27e-097.07e-0785
GO:004316110CervixCCproteasome-mediated ubiquitin-dependent protein catabolic process91/2311412/187231.65e-081.25e-0691
GO:00026837CervixCCnegative regulation of immune system process94/2311434/187232.63e-081.87e-0694
GO:00159809CervixCCenergy derivation by oxidation of organic compounds74/2311318/187233.83e-082.53e-0674
GO:19030378CervixCCregulation of leukocyte cell-cell adhesion77/2311336/187234.08e-082.54e-0677
GO:006219710CervixCCcellular response to chemical stress76/2311337/187231.01e-075.25e-0676
GO:200123410CervixCCnegative regulation of apoptotic signaling pathway56/2311224/187231.39e-076.70e-0656
GO:00018197CervixCCpositive regulation of cytokine production95/2311467/187234.88e-071.85e-0595
GO:00022379CervixCCresponse to molecule of bacterial origin78/2311363/187235.55e-072.06e-0578
GO:00324969CervixCCresponse to lipopolysaccharide74/2311343/187239.15e-073.25e-0574
GO:190589710CervixCCregulation of response to endoplasmic reticulum stress27/231182/187239.24e-073.25e-0527
GO:00509007CervixCCleukocyte migration78/2311369/187231.09e-063.80e-0578
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05418211EsophagusESCCFluid shear stress and atherosclerosis109/4205139/84652.00e-123.72e-111.90e-11109
hsa0466810EsophagusESCCTNF signaling pathway89/4205114/84653.36e-104.01e-092.06e-0989
hsa05417211EsophagusESCCLipid and atherosclerosis143/4205215/84653.30e-072.45e-061.26e-06143
hsa0493310EsophagusESCCAGE-RAGE signaling pathway in diabetic complications72/4205100/84654.15e-062.28e-051.17e-0572
hsa05418310EsophagusESCCFluid shear stress and atherosclerosis109/4205139/84652.00e-123.72e-111.90e-11109
hsa0466817EsophagusESCCTNF signaling pathway89/4205114/84653.36e-104.01e-092.06e-0989
hsa05417310EsophagusESCCLipid and atherosclerosis143/4205215/84653.30e-072.45e-061.26e-06143
hsa0493317EsophagusESCCAGE-RAGE signaling pathway in diabetic complications72/4205100/84654.15e-062.28e-051.17e-0572
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
SELECD44SELE_CD44SELEBreastADJ
SELEGLG1SELE_GLG1SELEBreastADJ
SELPLGSELESELPLG_SELESELPLGBreastADJ
SELECD44SELE_CD44SELEBreastHealthy
SELEGLG1SELE_GLG1SELEBreastHealthy
SELPLGSELESELPLG_SELESELPLGBreastHealthy
SELECEACAM1SELE_CEACAM1CEACAMBreastHealthy
SELECD44SELE_CD44SELEBreastPrecancer
SELECD44SELE_CD44SELECervixADJ
SELEGLG1SELE_GLG1SELECervixADJ
SELPLGSELESELPLG_SELESELPLGCervixADJ
SELECD44SELE_CD44SELECervixCC
SELEGLG1SELE_GLG1SELECervixCC
SELECEACAM1SELE_CEACAM1CEACAMCervixCC
SELPLGSELESELPLG_SELESELPLGCervixCC
SELECD44SELE_CD44SELEEndometriumADJ
SELEGLG1SELE_GLG1SELEEndometriumADJ
SELPLGSELESELPLG_SELESELPLGEndometriumADJ
SELECD44SELE_CD44SELEEndometriumAEH
SELEGLG1SELE_GLG1SELEEndometriumAEH
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SELESNVMissense_Mutationc.80N>Gp.Ser27Cysp.S27CP16581protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A0AL-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
SELESNVMissense_Mutationnovelc.464N>Gp.Val155Glyp.V155GP16581protein_codingdeleterious(0)probably_damaging(0.984)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SELEinsertionIn_Frame_Insnovelc.465_466insACTp.Val155_Glu156insThrp.V155_E156insTP16581protein_codingTCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SELESNVMissense_Mutationc.1681N>Tp.Leu561Phep.L561FP16581protein_codingdeleterious(0.01)probably_damaging(0.913)TCGA-Q1-A5R3-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPR
SELESNVMissense_Mutationc.113N>Ap.Ala38Aspp.A38DP16581protein_codingtolerated(0.57)benign(0.009)TCGA-VS-A9UB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SELESNVMissense_Mutationnovelc.518A>Gp.Lys173Argp.K173RP16581protein_codingtolerated(0.53)benign(0.003)TCGA-ZJ-AB0H-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
SELESNVMissense_Mutationc.1408N>Gp.Ser470Alap.S470AP16581protein_codingtolerated(0.13)benign(0.217)TCGA-AA-3811-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownPD
SELESNVMissense_Mutationc.113N>Tp.Ala38Valp.A38VP16581protein_codingtolerated(0.25)benign(0.069)TCGA-AZ-4313-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
SELESNVMissense_Mutationnovelc.544G>Ap.Ala182Thrp.A182TP16581protein_codingtolerated(0.24)possibly_damaging(0.543)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
SELESNVMissense_Mutationc.1758G>Tp.Lys586Asnp.K586NP16581protein_codingdeleterious(0)benign(0.42)TCGA-AZ-4614-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEleucovorinLEUCOVORIN24980946
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEBIMOSIAMOSEBIMOSIAMOSE
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEfluorouracilFLUOROURACIL24980946
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEcapecitabineCAPECITABINE24980946
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEinhibitorCHEMBL1215923BIMOSIAMOSE
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEBimosiamoseBIMOSIAMOSE
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEGMI-1359
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEGMI-1070RIVIPANSEL20508165
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANEantagonistCHEMBL3707446RIVIPANSEL
6401SELEDRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANESIALYL LEWIS XSIALYL LEWIS X
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