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Gene: PSMG2 |
Gene summary for PSMG2 |
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Gene information | Species | Human | Gene symbol | PSMG2 | Gene ID | 56984 |
Gene name | proteasome assembly chaperone 2 | |
Gene Alias | CLAST3 | |
Cytomap | 18p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q969U7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56984 | PSMG2 | LZE4T | Human | Esophagus | ESCC | 2.49e-13 | 5.65e-01 | 0.0811 |
56984 | PSMG2 | LZE5T | Human | Esophagus | ESCC | 8.77e-04 | 4.90e-01 | 0.0514 |
56984 | PSMG2 | LZE7T | Human | Esophagus | ESCC | 1.59e-07 | 8.25e-01 | 0.0667 |
56984 | PSMG2 | LZE8T | Human | Esophagus | ESCC | 1.33e-10 | 5.85e-01 | 0.067 |
56984 | PSMG2 | LZE20T | Human | Esophagus | ESCC | 1.66e-09 | 2.91e-01 | 0.0662 |
56984 | PSMG2 | LZE24T | Human | Esophagus | ESCC | 1.48e-20 | 9.05e-01 | 0.0596 |
56984 | PSMG2 | LZE21T | Human | Esophagus | ESCC | 2.57e-04 | 5.49e-01 | 0.0655 |
56984 | PSMG2 | P1T-E | Human | Esophagus | ESCC | 6.12e-05 | 6.60e-01 | 0.0875 |
56984 | PSMG2 | P2T-E | Human | Esophagus | ESCC | 1.09e-39 | 9.53e-01 | 0.1177 |
56984 | PSMG2 | P4T-E | Human | Esophagus | ESCC | 5.65e-48 | 1.38e+00 | 0.1323 |
56984 | PSMG2 | P5T-E | Human | Esophagus | ESCC | 1.46e-61 | 1.44e+00 | 0.1327 |
56984 | PSMG2 | P8T-E | Human | Esophagus | ESCC | 5.32e-45 | 9.27e-01 | 0.0889 |
56984 | PSMG2 | P9T-E | Human | Esophagus | ESCC | 9.21e-31 | 1.07e+00 | 0.1131 |
56984 | PSMG2 | P10T-E | Human | Esophagus | ESCC | 7.82e-35 | 6.82e-01 | 0.116 |
56984 | PSMG2 | P11T-E | Human | Esophagus | ESCC | 1.02e-22 | 9.89e-01 | 0.1426 |
56984 | PSMG2 | P12T-E | Human | Esophagus | ESCC | 2.96e-57 | 1.06e+00 | 0.1122 |
56984 | PSMG2 | P15T-E | Human | Esophagus | ESCC | 3.33e-52 | 1.27e+00 | 0.1149 |
56984 | PSMG2 | P16T-E | Human | Esophagus | ESCC | 3.97e-31 | 8.77e-01 | 0.1153 |
56984 | PSMG2 | P17T-E | Human | Esophagus | ESCC | 1.44e-09 | 8.01e-01 | 0.1278 |
56984 | PSMG2 | P19T-E | Human | Esophagus | ESCC | 8.92e-05 | 6.52e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00711734 | Thyroid | ATC | spindle assembly checkpoint | 27/6293 | 38/18723 | 2.64e-06 | 3.06e-05 | 27 |
GO:00711744 | Thyroid | ATC | mitotic spindle checkpoint | 27/6293 | 38/18723 | 2.64e-06 | 3.06e-05 | 27 |
GO:19021004 | Thyroid | ATC | negative regulation of metaphase/anaphase transition of cell cycle | 29/6293 | 42/18723 | 2.85e-06 | 3.27e-05 | 29 |
GO:00315774 | Thyroid | ATC | spindle checkpoint | 27/6293 | 39/18723 | 5.83e-06 | 6.16e-05 | 27 |
GO:00519854 | Thyroid | ATC | negative regulation of chromosome segregation | 30/6293 | 45/18723 | 5.89e-06 | 6.18e-05 | 30 |
GO:19058194 | Thyroid | ATC | negative regulation of chromosome separation | 30/6293 | 45/18723 | 5.89e-06 | 6.18e-05 | 30 |
GO:000007513 | Thyroid | ATC | cell cycle checkpoint | 84/6293 | 169/18723 | 1.05e-05 | 1.04e-04 | 84 |
GO:001094813 | Thyroid | ATC | negative regulation of cell cycle process | 134/6293 | 294/18723 | 1.19e-05 | 1.15e-04 | 134 |
GO:190198813 | Thyroid | ATC | negative regulation of cell cycle phase transition | 116/6293 | 249/18723 | 1.33e-05 | 1.27e-04 | 116 |
GO:005113132 | Thyroid | ATC | chaperone-mediated protein complex assembly | 14/6293 | 23/18723 | 6.70e-03 | 2.67e-02 | 14 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PSMG2 | SNV | Missense_Mutation | c.492N>C | p.Glu164Asp | p.E164D | Q969U7 | protein_coding | tolerated(0.06) | probably_damaging(0.948) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PSMG2 | SNV | Missense_Mutation | novel | c.625N>A | p.Ser209Thr | p.S209T | Q969U7 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSMG2 | insertion | In_Frame_Ins | novel | c.624_625insAAC | p.Val208_Ser209insAsn | p.V208_S209insN | Q969U7 | protein_coding | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PSMG2 | deletion | Frame_Shift_Del | c.778delN | p.Pro261LeufsTer36 | p.P261Lfs*36 | Q969U7 | protein_coding | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
PSMG2 | deletion | Frame_Shift_Del | c.26delN | p.Asp11ThrfsTer8 | p.D11Tfs*8 | Q969U7 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PSMG2 | deletion | Frame_Shift_Del | c.443delN | p.Ser150ValfsTer6 | p.S150Vfs*6 | Q969U7 | protein_coding | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PSMG2 | SNV | Missense_Mutation | c.161N>T | p.Pro54Leu | p.P54L | Q969U7 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PSMG2 | SNV | Missense_Mutation | c.691N>A | p.Leu231Ile | p.L231I | Q969U7 | protein_coding | tolerated(1) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PSMG2 | SNV | Missense_Mutation | novel | c.337A>C | p.Ser113Arg | p.S113R | Q969U7 | protein_coding | tolerated(0.06) | possibly_damaging(0.872) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSMG2 | SNV | Missense_Mutation | novel | c.782N>T | p.Pro261Leu | p.P261L | Q969U7 | protein_coding | tolerated(0.09) | possibly_damaging(0.677) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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