Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PCM1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PCM1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PCM1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PCM1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PCM1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PCM1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PCM1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PCM1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PCM1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00309006 | Skin | AK | forebrain development | 66/1910 | 379/18723 | 1.02e-05 | 2.17e-04 | 66 |
GO:003070519 | Skin | AK | cytoskeleton-dependent intracellular transport | 40/1910 | 195/18723 | 1.29e-05 | 2.58e-04 | 40 |
GO:003238823 | Skin | AK | positive regulation of intracellular transport | 41/1910 | 202/18723 | 1.32e-05 | 2.62e-04 | 41 |
GO:00311228 | Skin | AK | cytoplasmic microtubule organization | 17/1910 | 56/18723 | 2.63e-05 | 4.66e-04 | 17 |
GO:00519607 | Skin | AK | regulation of nervous system development | 72/1910 | 443/18723 | 4.53e-05 | 7.11e-04 | 72 |
GO:009031618 | Skin | AK | positive regulation of intracellular protein transport | 33/1910 | 160/18723 | 6.37e-05 | 9.31e-04 | 33 |
GO:00315036 | Skin | AK | protein-containing complex localization | 36/1910 | 220/18723 | 2.97e-03 | 1.87e-02 | 36 |
GO:00613513 | Skin | AK | neural precursor cell proliferation | 26/1910 | 145/18723 | 3.08e-03 | 1.92e-02 | 26 |
GO:00107215 | Skin | AK | negative regulation of cell development | 30/1910 | 180/18723 | 4.81e-03 | 2.74e-02 | 30 |
GO:00109708 | Skin | AK | transport along microtubule | 26/1910 | 155/18723 | 7.60e-03 | 3.86e-02 | 26 |
GO:00017644 | Skin | AK | neuron migration | 26/1910 | 156/18723 | 8.26e-03 | 4.13e-02 | 26 |
GO:005165624 | Skin | cSCC | establishment of organelle localization | 178/4864 | 390/18723 | 2.18e-17 | 2.32e-15 | 178 |
GO:0032386110 | Skin | cSCC | regulation of intracellular transport | 156/4864 | 337/18723 | 4.48e-16 | 3.96e-14 | 156 |
GO:003315724 | Skin | cSCC | regulation of intracellular protein transport | 115/4864 | 229/18723 | 2.74e-15 | 2.23e-13 | 115 |
GO:0032388111 | Skin | cSCC | positive regulation of intracellular transport | 96/4864 | 202/18723 | 3.14e-11 | 1.52e-09 | 96 |
GO:009031623 | Skin | cSCC | positive regulation of intracellular protein transport | 79/4864 | 160/18723 | 1.71e-10 | 7.52e-09 | 79 |
GO:1904951112 | Skin | cSCC | positive regulation of establishment of protein localization | 134/4864 | 319/18723 | 2.60e-10 | 1.09e-08 | 134 |
GO:0051222112 | Skin | cSCC | positive regulation of protein transport | 125/4864 | 303/18723 | 3.88e-09 | 1.32e-07 | 125 |
GO:003150315 | Skin | cSCC | protein-containing complex localization | 95/4864 | 220/18723 | 2.00e-08 | 5.82e-07 | 95 |
GO:001982715 | Skin | cSCC | stem cell population maintenance | 58/4864 | 131/18723 | 4.20e-06 | 6.24e-05 | 58 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCM1 | SNV | Missense_Mutation | rs374857257 | c.5357N>G | p.Ser1786Cys | p.S1786C | Q15154 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PCM1 | SNV | Missense_Mutation | novel | c.1067N>A | p.Ser356Tyr | p.S356Y | Q15154 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCM1 | SNV | Missense_Mutation | | c.3985N>C | p.Lys1329Gln | p.K1329Q | Q15154 | protein_coding | tolerated(0.46) | benign(0.077) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
PCM1 | insertion | Frame_Shift_Ins | novel | c.142_143insG | p.Asn48ArgfsTer2 | p.N48Rfs*2 | Q15154 | protein_coding | | | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
PCM1 | insertion | Nonsense_Mutation | novel | c.1270_1271insTCTAGGCTACTTATA | p.His424delinsLeuTerAlaThrTyrAsn | p.H424delinsL*ATYN | Q15154 | protein_coding | | | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | | CR |
PCM1 | insertion | Frame_Shift_Ins | novel | c.2643_2644insGGGCAGATCATGAGGTCAGGTATTCA | p.Arg882GlyfsTer26 | p.R882Gfs*26 | Q15154 | protein_coding | | | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
PCM1 | SNV | Missense_Mutation | rs768119487 | c.6034N>G | p.Thr2012Ala | p.T2012A | Q15154 | protein_coding | tolerated(0.59) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PCM1 | SNV | Missense_Mutation | | c.1435N>A | p.Glu479Lys | p.E479K | Q15154 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PCM1 | SNV | Missense_Mutation | | c.4408G>C | p.Asp1470His | p.D1470H | Q15154 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PCM1 | SNV | Missense_Mutation | novel | c.3398C>T | p.Ser1133Leu | p.S1133L | Q15154 | protein_coding | deleterious(0) | benign(0.225) | TCGA-VS-A954-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |