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Gene: MAF |
Gene summary for MAF |
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Gene information | Species | Human | Gene symbol | MAF | Gene ID | 4094 |
Gene name | MAF bZIP transcription factor | |
Gene Alias | AYGRP | |
Cytomap | 16q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O75444 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4094 | MAF | LZE4T | Human | Esophagus | ESCC | 6.27e-20 | 6.88e-01 | 0.0811 |
4094 | MAF | LZE20T | Human | Esophagus | ESCC | 4.14e-09 | 3.16e-01 | 0.0662 |
4094 | MAF | LZE24T | Human | Esophagus | ESCC | 1.70e-09 | 3.83e-01 | 0.0596 |
4094 | MAF | P1T-E | Human | Esophagus | ESCC | 4.23e-02 | 1.84e-01 | 0.0875 |
4094 | MAF | P2T-E | Human | Esophagus | ESCC | 1.34e-07 | 3.69e-02 | 0.1177 |
4094 | MAF | P4T-E | Human | Esophagus | ESCC | 8.80e-10 | 1.68e-01 | 0.1323 |
4094 | MAF | P5T-E | Human | Esophagus | ESCC | 3.27e-31 | 5.06e-01 | 0.1327 |
4094 | MAF | P8T-E | Human | Esophagus | ESCC | 6.55e-09 | 9.23e-02 | 0.0889 |
4094 | MAF | P9T-E | Human | Esophagus | ESCC | 6.99e-06 | 2.09e-01 | 0.1131 |
4094 | MAF | P10T-E | Human | Esophagus | ESCC | 9.13e-18 | 3.41e-01 | 0.116 |
4094 | MAF | P11T-E | Human | Esophagus | ESCC | 2.29e-09 | 5.97e-01 | 0.1426 |
4094 | MAF | P12T-E | Human | Esophagus | ESCC | 1.18e-15 | 2.40e-01 | 0.1122 |
4094 | MAF | P15T-E | Human | Esophagus | ESCC | 1.17e-03 | 2.07e-01 | 0.1149 |
4094 | MAF | P19T-E | Human | Esophagus | ESCC | 3.72e-02 | 2.16e-01 | 0.1662 |
4094 | MAF | P20T-E | Human | Esophagus | ESCC | 5.86e-08 | 2.28e-01 | 0.1124 |
4094 | MAF | P21T-E | Human | Esophagus | ESCC | 3.55e-13 | 1.94e-01 | 0.1617 |
4094 | MAF | P22T-E | Human | Esophagus | ESCC | 4.19e-47 | 8.28e-01 | 0.1236 |
4094 | MAF | P23T-E | Human | Esophagus | ESCC | 5.24e-06 | 2.14e-01 | 0.108 |
4094 | MAF | P24T-E | Human | Esophagus | ESCC | 3.30e-04 | 4.94e-02 | 0.1287 |
4094 | MAF | P26T-E | Human | Esophagus | ESCC | 3.18e-13 | 4.73e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004564610 | Prostate | BPH | regulation of erythrocyte differentiation | 19/3107 | 47/18723 | 8.77e-05 | 8.27e-04 | 19 |
GO:19021058 | Prostate | BPH | regulation of leukocyte differentiation | 71/3107 | 279/18723 | 9.94e-05 | 9.21e-04 | 71 |
GO:00085448 | Prostate | BPH | epidermis development | 80/3107 | 324/18723 | 1.12e-04 | 1.02e-03 | 80 |
GO:00147066 | Prostate | BPH | striated muscle tissue development | 91/3107 | 384/18723 | 1.90e-04 | 1.57e-03 | 91 |
GO:004211010 | Prostate | BPH | T cell activation | 111/3107 | 487/18723 | 2.11e-04 | 1.72e-03 | 111 |
GO:00454447 | Prostate | BPH | fat cell differentiation | 59/3107 | 229/18723 | 2.60e-04 | 2.04e-03 | 59 |
GO:00026839 | Prostate | BPH | negative regulation of immune system process | 100/3107 | 434/18723 | 2.83e-04 | 2.20e-03 | 100 |
GO:19031315 | Prostate | BPH | mononuclear cell differentiation | 98/3107 | 426/18723 | 3.43e-04 | 2.55e-03 | 98 |
GO:00099138 | Prostate | BPH | epidermal cell differentiation | 52/3107 | 202/18723 | 5.95e-04 | 4.11e-03 | 52 |
GO:00485384 | Prostate | BPH | thymus development | 16/3107 | 45/18723 | 1.62e-03 | 9.39e-03 | 16 |
GO:00027615 | Prostate | BPH | regulation of myeloid leukocyte differentiation | 33/3107 | 120/18723 | 1.76e-03 | 1.01e-02 | 33 |
GO:00456044 | Prostate | BPH | regulation of epidermal cell differentiation | 19/3107 | 58/18723 | 1.90e-03 | 1.08e-02 | 19 |
GO:0045638 | Prostate | BPH | negative regulation of myeloid cell differentiation | 26/3107 | 90/18723 | 2.46e-03 | 1.33e-02 | 26 |
GO:00300982 | Prostate | BPH | lymphocyte differentiation | 83/3107 | 374/18723 | 2.76e-03 | 1.46e-02 | 83 |
GO:00456824 | Prostate | BPH | regulation of epidermis development | 20/3107 | 65/18723 | 3.36e-03 | 1.73e-02 | 20 |
GO:00063562 | Prostate | BPH | regulation of transcription by RNA polymerase I | 12/3107 | 34/18723 | 6.45e-03 | 2.91e-02 | 12 |
GO:00302174 | Prostate | BPH | T cell differentiation | 58/3107 | 257/18723 | 7.66e-03 | 3.39e-02 | 58 |
GO:00605383 | Prostate | BPH | skeletal muscle organ development | 40/3107 | 166/18723 | 8.09e-03 | 3.52e-02 | 40 |
GO:00075175 | Prostate | BPH | muscle organ development | 71/3107 | 327/18723 | 9.00e-03 | 3.84e-02 | 71 |
GO:00303163 | Prostate | BPH | osteoclast differentiation | 25/3107 | 94/18723 | 9.36e-03 | 3.98e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa046585 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0465812 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa046584 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
hsa0465811 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAF | SNV | Missense_Mutation | novel | c.1082C>T | p.Ser361Leu | p.S361L | O75444 | protein_coding | deleterious(0) | possibly_damaging(0.902) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAF | SNV | Missense_Mutation | rs377735141 | c.1159N>A | p.Ala387Thr | p.A387T | O75444 | protein_coding | tolerated_low_confidence(0.16) | benign(0) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAF | SNV | Missense_Mutation | rs759815012 | c.314N>T | p.Ala105Val | p.A105V | O75444 | protein_coding | tolerated(0.08) | probably_damaging(0.92) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
MAF | SNV | Missense_Mutation | c.1015N>T | p.Arg339Cys | p.R339C | O75444 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MAF | SNV | Missense_Mutation | novel | c.842N>G | p.Val281Gly | p.V281G | O75444 | protein_coding | deleterious(0.01) | probably_damaging(0.92) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAF | SNV | Missense_Mutation | c.227C>T | p.Pro76Leu | p.P76L | O75444 | protein_coding | deleterious(0) | benign(0.203) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MAF | SNV | Missense_Mutation | c.58G>A | p.Glu20Lys | p.E20K | O75444 | protein_coding | deleterious(0) | possibly_damaging(0.807) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAF | SNV | Missense_Mutation | c.1097N>T | p.Pro366Leu | p.P366L | O75444 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MAF | SNV | Missense_Mutation | novel | c.929T>C | p.Val310Ala | p.V310A | O75444 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAF | deletion | Frame_Shift_Del | novel | c.206delC | p.Pro69LeufsTer26 | p.P69Lfs*26 | O75444 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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