![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: IMP3 |
Gene summary for IMP3 |
![]() |
Gene information | Species | Human | Gene symbol | IMP3 | Gene ID | 55272 |
Gene name | IMP U3 small nucleolar ribonucleoprotein 3 | |
Gene Alias | BRMS2 | |
Cytomap | 15q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NV31 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55272 | IMP3 | LZE4T | Human | Esophagus | ESCC | 3.54e-19 | 7.34e-01 | 0.0811 |
55272 | IMP3 | LZE7T | Human | Esophagus | ESCC | 3.48e-17 | 1.21e+00 | 0.0667 |
55272 | IMP3 | LZE8T | Human | Esophagus | ESCC | 1.72e-08 | 4.75e-01 | 0.067 |
55272 | IMP3 | LZE20T | Human | Esophagus | ESCC | 2.01e-08 | 3.28e-01 | 0.0662 |
55272 | IMP3 | LZE22T | Human | Esophagus | ESCC | 1.56e-04 | 6.43e-01 | 0.068 |
55272 | IMP3 | LZE24T | Human | Esophagus | ESCC | 5.53e-16 | 6.28e-01 | 0.0596 |
55272 | IMP3 | LZE21T | Human | Esophagus | ESCC | 6.14e-04 | 6.07e-01 | 0.0655 |
55272 | IMP3 | LZE6T | Human | Esophagus | ESCC | 1.56e-03 | 3.95e-01 | 0.0845 |
55272 | IMP3 | P1T-E | Human | Esophagus | ESCC | 5.65e-15 | 1.20e+00 | 0.0875 |
55272 | IMP3 | P2T-E | Human | Esophagus | ESCC | 8.77e-30 | 7.02e-01 | 0.1177 |
55272 | IMP3 | P4T-E | Human | Esophagus | ESCC | 2.02e-56 | 1.72e+00 | 0.1323 |
55272 | IMP3 | P5T-E | Human | Esophagus | ESCC | 1.93e-20 | 5.13e-01 | 0.1327 |
55272 | IMP3 | P8T-E | Human | Esophagus | ESCC | 7.40e-45 | 9.29e-01 | 0.0889 |
55272 | IMP3 | P9T-E | Human | Esophagus | ESCC | 7.23e-46 | 1.28e+00 | 0.1131 |
55272 | IMP3 | P10T-E | Human | Esophagus | ESCC | 1.28e-62 | 1.20e+00 | 0.116 |
55272 | IMP3 | P11T-E | Human | Esophagus | ESCC | 5.06e-19 | 1.12e+00 | 0.1426 |
55272 | IMP3 | P12T-E | Human | Esophagus | ESCC | 7.53e-45 | 1.06e+00 | 0.1122 |
55272 | IMP3 | P15T-E | Human | Esophagus | ESCC | 2.28e-53 | 1.19e+00 | 0.1149 |
55272 | IMP3 | P16T-E | Human | Esophagus | ESCC | 8.87e-54 | 1.31e+00 | 0.1153 |
55272 | IMP3 | P17T-E | Human | Esophagus | ESCC | 1.08e-11 | 5.27e-01 | 0.1278 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176112 | Skin | SCCIS | regulation of protein catabolic process | 54/919 | 391/18723 | 5.60e-12 | 7.43e-09 | 54 |
GO:2001236112 | Skin | SCCIS | regulation of extrinsic apoptotic signaling pathway | 24/919 | 151/18723 | 3.42e-07 | 3.03e-05 | 24 |
GO:0045861112 | Skin | SCCIS | negative regulation of proteolysis | 40/919 | 351/18723 | 6.58e-07 | 5.13e-05 | 40 |
GO:190204119 | Skin | SCCIS | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 12/919 | 49/18723 | 3.12e-06 | 1.49e-04 | 12 |
GO:2001235111 | Skin | SCCIS | positive regulation of apoptotic signaling pathway | 20/919 | 126/18723 | 3.27e-06 | 1.53e-04 | 20 |
GO:0052547112 | Skin | SCCIS | regulation of peptidase activity | 46/919 | 461/18723 | 4.09e-06 | 1.82e-04 | 46 |
GO:0052548112 | Skin | SCCIS | regulation of endopeptidase activity | 43/919 | 432/18723 | 8.92e-06 | 3.22e-04 | 43 |
GO:007037114 | Skin | SCCIS | ERK1 and ERK2 cascade | 35/919 | 330/18723 | 1.59e-05 | 4.98e-04 | 35 |
GO:200123819 | Skin | SCCIS | positive regulation of extrinsic apoptotic signaling pathway | 11/919 | 48/18723 | 1.59e-05 | 4.98e-04 | 11 |
GO:190204315 | Skin | SCCIS | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | 6/919 | 13/18723 | 1.75e-05 | 5.38e-04 | 6 |
GO:0051346111 | Skin | SCCIS | negative regulation of hydrolase activity | 38/919 | 379/18723 | 2.49e-05 | 6.97e-04 | 38 |
GO:0097191112 | Skin | SCCIS | extrinsic apoptotic signaling pathway | 26/919 | 219/18723 | 2.87e-05 | 7.82e-04 | 26 |
GO:0010951110 | Skin | SCCIS | negative regulation of endopeptidase activity | 28/919 | 252/18723 | 4.82e-05 | 1.18e-03 | 28 |
GO:0042177112 | Skin | SCCIS | negative regulation of protein catabolic process | 17/919 | 121/18723 | 8.66e-05 | 1.98e-03 | 17 |
GO:0010466110 | Skin | SCCIS | negative regulation of peptidase activity | 28/919 | 262/18723 | 9.55e-05 | 2.12e-03 | 28 |
GO:0031330112 | Skin | SCCIS | negative regulation of cellular catabolic process | 28/919 | 262/18723 | 9.55e-05 | 2.12e-03 | 28 |
GO:00703725 | Skin | SCCIS | regulation of ERK1 and ERK2 cascade | 31/919 | 309/18723 | 1.34e-04 | 2.77e-03 | 31 |
GO:0008625110 | Skin | SCCIS | extrinsic apoptotic signaling pathway via death domain receptors | 13/919 | 82/18723 | 1.69e-04 | 3.32e-03 | 13 |
GO:0043409111 | Skin | SCCIS | negative regulation of MAPK cascade | 21/919 | 180/18723 | 2.09e-04 | 3.93e-03 | 21 |
GO:0009895112 | Skin | SCCIS | negative regulation of catabolic process | 30/919 | 320/18723 | 5.43e-04 | 8.33e-03 | 30 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IMP3 | SNV | Missense_Mutation | rs746193463 | c.227C>T | p.Ser76Leu | p.S76L | Q9NV31 | protein_coding | deleterious(0.02) | benign(0.242) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
IMP3 | SNV | Missense_Mutation | c.538N>G | p.Phe180Val | p.F180V | Q9NV31 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
IMP3 | SNV | Missense_Mutation | rs200453864 | c.521N>G | p.Asn174Ser | p.N174S | Q9NV31 | protein_coding | deleterious(0.04) | benign(0.063) | TCGA-AG-3594-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
IMP3 | SNV | Missense_Mutation | novel | c.268N>T | p.Pro90Ser | p.P90S | Q9NV31 | protein_coding | tolerated(0.53) | benign(0.015) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
IMP3 | SNV | Missense_Mutation | novel | c.541N>C | p.Asp181His | p.D181H | Q9NV31 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-HD-A4C1-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IMP3 | insertion | Frame_Shift_Ins | novel | c.456_457insGC | p.Ser153AlafsTer20 | p.S153Afs*20 | Q9NV31 | protein_coding | TCGA-CV-6003-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
IMP3 | SNV | Missense_Mutation | c.540N>A | p.Phe180Leu | p.F180L | Q9NV31 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-G9-7510-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |