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Gene: HNRNPC |
Gene summary for HNRNPC |
Gene summary. |
Gene information | Species | Human | Gene symbol | HNRNPC | Gene ID | 3183 |
Gene name | heterogeneous nuclear ribonucleoprotein C | |
Gene Alias | C1 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P07910 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3183 | HNRNPC | GSM4909277 | Human | Breast | Precancer | 6.77e-03 | 2.38e-01 | 0.0177 |
3183 | HNRNPC | GSM4909286 | Human | Breast | IDC | 1.59e-04 | -1.13e-01 | 0.1081 |
3183 | HNRNPC | GSM4909287 | Human | Breast | IDC | 3.42e-04 | 4.72e-02 | 0.2057 |
3183 | HNRNPC | GSM4909288 | Human | Breast | IDC | 4.84e-04 | -5.99e-02 | 0.0988 |
3183 | HNRNPC | GSM4909292 | Human | Breast | IDC | 8.62e-03 | -5.22e-01 | 0.1236 |
3183 | HNRNPC | GSM4909293 | Human | Breast | IDC | 5.82e-10 | 3.35e-01 | 0.1581 |
3183 | HNRNPC | GSM4909294 | Human | Breast | IDC | 3.39e-09 | -1.41e-01 | 0.2022 |
3183 | HNRNPC | GSM4909296 | Human | Breast | IDC | 2.15e-15 | -1.67e-01 | 0.1524 |
3183 | HNRNPC | GSM4909297 | Human | Breast | IDC | 1.66e-24 | -2.69e-01 | 0.1517 |
3183 | HNRNPC | GSM4909302 | Human | Breast | IDC | 3.63e-03 | -8.62e-02 | 0.1545 |
3183 | HNRNPC | GSM4909309 | Human | Breast | IDC | 1.50e-05 | -3.67e-02 | 0.0483 |
3183 | HNRNPC | GSM4909311 | Human | Breast | IDC | 1.02e-50 | -6.63e-01 | 0.1534 |
3183 | HNRNPC | GSM4909312 | Human | Breast | IDC | 3.12e-13 | -1.73e-02 | 0.1552 |
3183 | HNRNPC | GSM4909313 | Human | Breast | IDC | 2.99e-05 | -6.29e-02 | 0.0391 |
3183 | HNRNPC | GSM4909316 | Human | Breast | IDC | 5.77e-08 | -4.37e-01 | 0.21 |
3183 | HNRNPC | GSM4909319 | Human | Breast | IDC | 1.34e-66 | -4.37e-01 | 0.1563 |
3183 | HNRNPC | GSM4909320 | Human | Breast | IDC | 1.97e-11 | -3.91e-01 | 0.1575 |
3183 | HNRNPC | GSM4909321 | Human | Breast | IDC | 1.93e-19 | -1.45e-01 | 0.1559 |
3183 | HNRNPC | ctrl6 | Human | Breast | Precancer | 7.78e-09 | 4.38e-01 | -0.0061 |
3183 | HNRNPC | brca2 | Human | Breast | Precancer | 2.12e-02 | 1.52e-01 | -0.024 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00610135 | Colorectum | CRC | regulation of mRNA catabolic process | 45/2078 | 166/18723 | 8.14e-09 | 1.85e-06 | 45 |
GO:00313305 | Colorectum | CRC | negative regulation of cellular catabolic process | 61/2078 | 262/18723 | 1.27e-08 | 2.54e-06 | 61 |
GO:00064015 | Colorectum | CRC | RNA catabolic process | 63/2078 | 278/18723 | 2.21e-08 | 3.23e-06 | 63 |
GO:00434885 | Colorectum | CRC | regulation of mRNA stability | 40/2078 | 158/18723 | 3.96e-07 | 3.21e-05 | 40 |
GO:00003775 | Colorectum | CRC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/2078 | 320/18723 | 4.39e-07 | 3.37e-05 | 66 |
GO:00003985 | Colorectum | CRC | mRNA splicing, via spliceosome | 66/2078 | 320/18723 | 4.39e-07 | 3.37e-05 | 66 |
GO:00003755 | Colorectum | CRC | RNA splicing, via transesterification reactions | 66/2078 | 324/18723 | 7.00e-07 | 4.61e-05 | 66 |
GO:00434875 | Colorectum | CRC | regulation of RNA stability | 41/2078 | 170/18723 | 1.13e-06 | 6.69e-05 | 41 |
GO:00510525 | Colorectum | CRC | regulation of DNA metabolic process | 70/2078 | 359/18723 | 1.75e-06 | 8.92e-05 | 70 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:00346555 | Colorectum | CRC | nucleobase-containing compound catabolic process | 73/2078 | 407/18723 | 2.28e-05 | 6.57e-04 | 73 |
GO:20002785 | Colorectum | CRC | regulation of DNA biosynthetic process | 27/2078 | 106/18723 | 2.59e-05 | 7.16e-04 | 27 |
GO:00442705 | Colorectum | CRC | cellular nitrogen compound catabolic process | 78/2078 | 451/18723 | 4.48e-05 | 1.07e-03 | 78 |
GO:00467005 | Colorectum | CRC | heterocycle catabolic process | 77/2078 | 445/18723 | 4.92e-05 | 1.14e-03 | 77 |
GO:00106394 | Colorectum | CRC | negative regulation of organelle organization | 63/2078 | 348/18723 | 6.09e-05 | 1.35e-03 | 63 |
GO:19033125 | Colorectum | CRC | negative regulation of mRNA metabolic process | 23/2078 | 92/18723 | 1.36e-04 | 2.56e-03 | 23 |
GO:19023694 | Colorectum | CRC | negative regulation of RNA catabolic process | 20/2078 | 75/18723 | 1.42e-04 | 2.62e-03 | 20 |
GO:00194395 | Colorectum | CRC | aromatic compound catabolic process | 77/2078 | 467/18723 | 2.42e-04 | 4.00e-03 | 77 |
GO:00330443 | Colorectum | CRC | regulation of chromosome organization | 37/2078 | 187/18723 | 3.34e-04 | 5.10e-03 | 37 |
GO:19013615 | Colorectum | CRC | organic cyclic compound catabolic process | 80/2078 | 495/18723 | 3.52e-04 | 5.34e-03 | 80 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPC | SNV | Missense_Mutation | rs199624650 | c.742N>C | p.Asn248His | p.N248H | P07910 | protein_coding | tolerated(0.21) | benign(0) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HNRNPC | SNV | Missense_Mutation | c.571G>A | p.Asp191Asn | p.D191N | P07910 | protein_coding | tolerated(0.15) | probably_damaging(0.94) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
HNRNPC | SNV | Missense_Mutation | c.545N>A | p.Ser182Tyr | p.S182Y | P07910 | protein_coding | deleterious(0.01) | probably_damaging(0.949) | TCGA-OL-A5D6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPC | SNV | Missense_Mutation | novel | c.188C>G | p.Ala63Gly | p.A63G | P07910 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
HNRNPC | SNV | Missense_Mutation | c.913N>A | p.Asp305Asn | p.D305N | P07910 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.971) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HNRNPC | SNV | Missense_Mutation | novel | c.309N>T | p.Glu103Asp | p.E103D | P07910 | protein_coding | tolerated(0.41) | benign(0.003) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HNRNPC | SNV | Missense_Mutation | c.299C>A | p.Ser100Tyr | p.S100Y | P07910 | protein_coding | deleterious(0) | benign(0.009) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HNRNPC | SNV | Missense_Mutation | c.32N>T | p.Pro11Leu | p.P11L | P07910 | protein_coding | deleterious(0) | benign(0.414) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HNRNPC | SNV | Missense_Mutation | novel | c.793N>A | p.Asp265Asn | p.D265N | P07910 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HNRNPC | insertion | Frame_Shift_Ins | novel | c.440_441insC | p.Pro148SerfsTer29 | p.P148Sfs*29 | P07910 | protein_coding | TCGA-AD-6548-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3183 | HNRNPC | NA | DABIGATRAN | DABIGATRAN | 22494098 |
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