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Gene: FGFR2 |
Gene summary for FGFR2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FGFR2 | Gene ID | 2263 |
Gene name | fibroblast growth factor receptor 2 | |
Gene Alias | BBDS | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P21802 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2263 | FGFR2 | CA_HPV_1 | Human | Cervix | CC | 8.51e-05 | -1.49e-01 | 0.0264 |
2263 | FGFR2 | CA_HPV_3 | Human | Cervix | CC | 1.97e-23 | 4.50e-01 | 0.0414 |
2263 | FGFR2 | CCI_1 | Human | Cervix | CC | 6.18e-03 | 6.82e-01 | 0.528 |
2263 | FGFR2 | CCI_2 | Human | Cervix | CC | 1.04e-03 | 6.95e-01 | 0.5249 |
2263 | FGFR2 | CCI_3 | Human | Cervix | CC | 2.01e-02 | 5.07e-01 | 0.516 |
2263 | FGFR2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.06e-04 | 4.09e-01 | -0.0811 |
2263 | FGFR2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.15e-10 | 7.37e-01 | -0.1088 |
2263 | FGFR2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.90e-02 | 5.56e-01 | -0.1526 |
2263 | FGFR2 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.09e-11 | 5.73e-01 | -0.1001 |
2263 | FGFR2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.04e-03 | 4.46e-01 | -0.059 |
2263 | FGFR2 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.24e-03 | 5.32e-01 | -0.0842 |
2263 | FGFR2 | A008-E-015 | Human | Colorectum | FAP | 1.76e-02 | 2.45e-01 | 0.0177 |
2263 | FGFR2 | CRC-1-8810 | Human | Colorectum | CRC | 2.86e-02 | -1.80e-01 | 0.6257 |
2263 | FGFR2 | AEH-subject1 | Human | Endometrium | AEH | 1.28e-05 | 3.41e-01 | -0.3059 |
2263 | FGFR2 | AEH-subject3 | Human | Endometrium | AEH | 2.22e-08 | 3.63e-01 | -0.2576 |
2263 | FGFR2 | AEH-subject5 | Human | Endometrium | AEH | 2.41e-14 | 5.35e-01 | -0.2953 |
2263 | FGFR2 | EEC-subject1 | Human | Endometrium | EEC | 2.50e-13 | 5.55e-01 | -0.2682 |
2263 | FGFR2 | EEC-subject2 | Human | Endometrium | EEC | 1.22e-25 | 6.67e-01 | -0.2607 |
2263 | FGFR2 | EEC-subject5 | Human | Endometrium | EEC | 1.43e-05 | 2.79e-01 | -0.249 |
2263 | FGFR2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.88e-11 | 2.52e-01 | -0.1869 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00601734 | Colorectum | CRC | limb development | 34/2078 | 172/18723 | 5.80e-04 | 7.89e-03 | 34 |
GO:00488631 | Colorectum | CRC | stem cell differentiation | 39/2078 | 206/18723 | 5.89e-04 | 7.89e-03 | 39 |
GO:00467774 | Colorectum | CRC | protein autophosphorylation | 42/2078 | 227/18723 | 6.08e-04 | 8.10e-03 | 42 |
GO:00435881 | Colorectum | CRC | skin development | 47/2078 | 263/18723 | 6.63e-04 | 8.74e-03 | 47 |
GO:00309015 | Colorectum | CRC | midbrain development | 21/2078 | 90/18723 | 7.06e-04 | 9.17e-03 | 21 |
GO:00351483 | Colorectum | CRC | tube formation | 30/2078 | 148/18723 | 7.75e-04 | 9.87e-03 | 30 |
GO:00606881 | Colorectum | CRC | regulation of morphogenesis of a branching structure | 14/2078 | 50/18723 | 8.08e-04 | 1.02e-02 | 14 |
GO:0003007 | Colorectum | CRC | heart morphogenesis | 44/2078 | 246/18723 | 9.49e-04 | 1.15e-02 | 44 |
GO:00487622 | Colorectum | CRC | mesenchymal cell differentiation | 42/2078 | 236/18723 | 1.35e-03 | 1.50e-02 | 42 |
GO:00016494 | Colorectum | CRC | osteoblast differentiation | 41/2078 | 229/18723 | 1.36e-03 | 1.50e-02 | 41 |
GO:00303231 | Colorectum | CRC | respiratory tube development | 34/2078 | 181/18723 | 1.47e-03 | 1.57e-02 | 34 |
GO:0021879 | Colorectum | CRC | forebrain neuron differentiation | 12/2078 | 42/18723 | 1.55e-03 | 1.63e-02 | 12 |
GO:00218592 | Colorectum | CRC | pyramidal neuron differentiation | 6/2078 | 13/18723 | 1.59e-03 | 1.68e-02 | 6 |
GO:00506733 | Colorectum | CRC | epithelial cell proliferation | 69/2078 | 437/18723 | 1.61e-03 | 1.69e-02 | 69 |
GO:00017633 | Colorectum | CRC | morphogenesis of a branching structure | 36/2078 | 196/18723 | 1.64e-03 | 1.70e-02 | 36 |
GO:00604281 | Colorectum | CRC | lung epithelium development | 11/2078 | 37/18723 | 1.69e-03 | 1.75e-02 | 11 |
GO:00303241 | Colorectum | CRC | lung development | 33/2078 | 177/18723 | 1.94e-03 | 1.96e-02 | 33 |
GO:00604851 | Colorectum | CRC | mesenchyme development | 49/2078 | 291/18723 | 1.94e-03 | 1.96e-02 | 49 |
GO:0060348 | Colorectum | CRC | bone development | 37/2078 | 205/18723 | 1.96e-03 | 1.96e-02 | 37 |
GO:0002065 | Colorectum | CRC | columnar/cuboidal epithelial cell differentiation | 20/2078 | 91/18723 | 2.04e-03 | 2.03e-02 | 20 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa052157 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0523010 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa0481017 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0521512 | Cervix | CC | Prostate cancer | 27/1267 | 97/8465 | 7.54e-04 | 3.39e-03 | 2.01e-03 | 27 |
hsa0401411 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0523013 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa05215 | Colorectum | AD | Prostate cancer | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa01521 | Colorectum | AD | EGFR tyrosine kinase inhibitor resistance | 29/2092 | 79/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 29 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Cervix | ADJ |
FGF1 | FGFR2 | FGF1_FGFR2 | FGF | Cervix | CC |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Cervix | CC |
FGF2 | FGFR2 | FGF2_FGFR2 | FGF | CRC | ADJ |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | CRC | CRC |
FGF2 | FGFR2 | FGF2_FGFR2 | FGF | Endometrium | ADJ |
FGF2 | FGFR2 | FGF2_FGFR2 | FGF | Endometrium | AEH |
FGF2 | FGFR2 | FGF2_FGFR2 | FGF | Endometrium | EEC |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Endometrium | EEC |
FGF1 | FGFR2 | FGF1_FGFR2 | FGF | HNSCC | OSCC |
FGF2 | FGFR2 | FGF2_FGFR2 | FGF | HNSCC | OSCC |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | HNSCC | OSCC |
FGF18 | FGFR2 | FGF18_FGFR2 | FGF | HNSCC | OSCC |
FGF2 | FGFR2 | FGF2_FGFR2 | FGF | HNSCC | Precancer |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | HNSCC | Precancer |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Lung | AAH |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Lung | ADJ |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Lung | AIS |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Lung | IAC |
FGF7 | FGFR2 | FGF7_FGFR2 | FGF | Lung | Precancer |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FGFR2 | SNV | Missense_Mutation | rs779423644 | c.364G>A | p.Val122Met | p.V122M | P21802 | protein_coding | deleterious(0.01) | possibly_damaging(0.902) | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
FGFR2 | SNV | Missense_Mutation | c.338N>C | p.Val113Ala | p.V113A | P21802 | protein_coding | tolerated(0.52) | benign(0.1) | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
FGFR2 | SNV | Missense_Mutation | c.1763N>G | p.Ser588Cys | p.S588C | P21802 | protein_coding | tolerated(0.31) | possibly_damaging(0.857) | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FGFR2 | SNV | Missense_Mutation | c.785N>C | p.Leu262Pro | p.L262P | P21802 | protein_coding | deleterious(0.01) | probably_damaging(0.937) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FGFR2 | SNV | Missense_Mutation | novel | c.1904N>C | p.Val635Ala | p.V635A | P21802 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FGFR2 | SNV | Missense_Mutation | rs121913474 | c.1147T>C | p.Cys383Arg | p.C383R | P21802 | protein_coding | deleterious(0.02) | possibly_damaging(0.865) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FGFR2 | SNV | Missense_Mutation | c.1650T>G | p.Asn550Lys | p.N550K | P21802 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FGFR2 | SNV | Missense_Mutation | c.1099N>C | p.Glu367Gln | p.E367Q | P21802 | protein_coding | tolerated(0.19) | benign(0.156) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
FGFR2 | SNV | Missense_Mutation | rs121913476 | c.1650T>A | p.Asn550Lys | p.N550K | P21802 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide+tamoxifen | SD |
FGFR2 | SNV | Missense_Mutation | c.1414G>T | p.Asp472Tyr | p.D472Y | P21802 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | AZ6089 | 22869148 | ||
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | CVBT-141H | |||
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | inhibitor | BGJ398 | INFIGRATINIB | |
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | DOVITINIB | DOVITINIB | ||
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | inhibitor | 252827519 | ||
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | TRAFERMIN | TRAFERMIN | ||
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | inhibitor | NINTEDANIB | NINTEDANIB | |
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | Trametinib | TRAMETINIB | 27338794 | |
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | inhibitor | CHEMBL1852688 | INFIGRATINIB | |
2263 | FGFR2 | KINASE, DRUGGABLE GENOME, TYROSINE KINASE, CLINICALLY ACTIONABLE, CELL SURFACE | inhibitor | LENVATINIB | LENVATINIB |
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