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Gene: ECT2 |
Gene summary for ECT2 |
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Gene information | Species | Human | Gene symbol | ECT2 | Gene ID | 1894 |
Gene name | epithelial cell transforming 2 | |
Gene Alias | ARHGEF31 | |
Cytomap | 3q26.31 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9H8V3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1894 | ECT2 | CA_HPV_2 | Human | Cervix | CC | 1.63e-10 | 3.63e-01 | 0.0391 |
1894 | ECT2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.14e-04 | 2.37e-01 | 0.0208 |
1894 | ECT2 | CCI_2 | Human | Cervix | CC | 5.01e-20 | 1.99e+00 | 0.5249 |
1894 | ECT2 | CCI_3 | Human | Cervix | CC | 7.19e-19 | 9.38e-01 | 0.516 |
1894 | ECT2 | Tumor | Human | Cervix | CC | 3.12e-03 | 2.36e-01 | 0.1241 |
1894 | ECT2 | sample1 | Human | Cervix | CC | 3.51e-03 | 2.94e-01 | 0.0959 |
1894 | ECT2 | sample3 | Human | Cervix | CC | 3.24e-14 | 2.50e-01 | 0.1387 |
1894 | ECT2 | T1 | Human | Cervix | CC | 1.20e-02 | 2.00e-01 | 0.0918 |
1894 | ECT2 | T3 | Human | Cervix | CC | 4.43e-12 | 2.60e-01 | 0.1389 |
1894 | ECT2 | LZE2T | Human | Esophagus | ESCC | 6.82e-10 | 1.29e+00 | 0.082 |
1894 | ECT2 | LZE4T | Human | Esophagus | ESCC | 7.97e-07 | 2.79e-01 | 0.0811 |
1894 | ECT2 | LZE7T | Human | Esophagus | ESCC | 7.96e-08 | 4.88e-01 | 0.0667 |
1894 | ECT2 | LZE22T | Human | Esophagus | ESCC | 9.88e-03 | 2.61e-01 | 0.068 |
1894 | ECT2 | LZE24T | Human | Esophagus | ESCC | 2.55e-02 | 1.72e-01 | 0.0596 |
1894 | ECT2 | LZE21T | Human | Esophagus | ESCC | 1.61e-08 | 4.81e-01 | 0.0655 |
1894 | ECT2 | LZE6T | Human | Esophagus | ESCC | 2.39e-04 | 1.73e-01 | 0.0845 |
1894 | ECT2 | P2T-E | Human | Esophagus | ESCC | 3.98e-14 | 7.67e-01 | 0.1177 |
1894 | ECT2 | P4T-E | Human | Esophagus | ESCC | 1.64e-14 | 5.33e-01 | 0.1323 |
1894 | ECT2 | P5T-E | Human | Esophagus | ESCC | 4.20e-15 | 5.56e-01 | 0.1327 |
1894 | ECT2 | P8T-E | Human | Esophagus | ESCC | 1.50e-08 | 3.46e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046822111 | Skin | cSCC | regulation of nucleocytoplasmic transport | 59/4864 | 106/18723 | 8.03e-11 | 3.68e-09 | 59 |
GO:000091021 | Skin | cSCC | cytokinesis | 84/4864 | 173/18723 | 1.36e-10 | 6.04e-09 | 84 |
GO:009031623 | Skin | cSCC | positive regulation of intracellular protein transport | 79/4864 | 160/18723 | 1.71e-10 | 7.52e-09 | 79 |
GO:1904951112 | Skin | cSCC | positive regulation of establishment of protein localization | 134/4864 | 319/18723 | 2.60e-10 | 1.09e-08 | 134 |
GO:190018022 | Skin | cSCC | regulation of protein localization to nucleus | 69/4864 | 136/18723 | 5.37e-10 | 2.14e-08 | 69 |
GO:005117016 | Skin | cSCC | import into nucleus | 77/4864 | 159/18723 | 9.17e-10 | 3.58e-08 | 77 |
GO:006219729 | Skin | cSCC | cellular response to chemical stress | 138/4864 | 337/18723 | 1.10e-09 | 4.23e-08 | 138 |
GO:007147824 | Skin | cSCC | cellular response to radiation | 86/4864 | 186/18723 | 1.81e-09 | 6.67e-08 | 86 |
GO:190018219 | Skin | cSCC | positive regulation of protein localization to nucleus | 49/4864 | 87/18723 | 1.84e-09 | 6.73e-08 | 49 |
GO:007121425 | Skin | cSCC | cellular response to abiotic stimulus | 135/4864 | 331/18723 | 2.26e-09 | 8.11e-08 | 135 |
GO:010400425 | Skin | cSCC | cellular response to environmental stimulus | 135/4864 | 331/18723 | 2.26e-09 | 8.11e-08 | 135 |
GO:0051222112 | Skin | cSCC | positive regulation of protein transport | 125/4864 | 303/18723 | 3.88e-09 | 1.32e-07 | 125 |
GO:000030228 | Skin | cSCC | response to reactive oxygen species | 97/4864 | 222/18723 | 6.88e-09 | 2.25e-07 | 97 |
GO:0043123110 | Skin | cSCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 84/4864 | 186/18723 | 1.09e-08 | 3.40e-07 | 84 |
GO:000660615 | Skin | cSCC | protein import into nucleus | 73/4864 | 155/18723 | 1.13e-08 | 3.48e-07 | 73 |
GO:000724925 | Skin | cSCC | I-kappaB kinase/NF-kappaB signaling | 116/4864 | 281/18723 | 1.33e-08 | 4.08e-07 | 116 |
GO:004312225 | Skin | cSCC | regulation of I-kappaB kinase/NF-kappaB signaling | 105/4864 | 249/18723 | 1.70e-08 | 5.09e-07 | 105 |
GO:00325067 | Skin | cSCC | cytokinetic process | 27/4864 | 39/18723 | 1.87e-08 | 5.53e-07 | 27 |
GO:003459928 | Skin | cSCC | cellular response to oxidative stress | 117/4864 | 288/18723 | 3.37e-08 | 8.95e-07 | 117 |
GO:004254227 | Skin | cSCC | response to hydrogen peroxide | 68/4864 | 146/18723 | 6.10e-08 | 1.56e-06 | 68 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ECT2 | SNV | Missense_Mutation | c.1235N>T | p.Ser412Phe | p.S412F | Q9H8V3 | protein_coding | deleterious(0.01) | probably_damaging(0.943) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ECT2 | SNV | Missense_Mutation | c.2594N>A | p.Arg865Lys | p.R865K | Q9H8V3 | protein_coding | tolerated(0.94) | benign(0.003) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ECT2 | SNV | Missense_Mutation | novel | c.646N>G | p.His216Asp | p.H216D | Q9H8V3 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ECT2 | SNV | Missense_Mutation | novel | c.1580A>G | p.Asp527Gly | p.D527G | Q9H8V3 | protein_coding | tolerated(0.05) | benign(0.012) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ECT2 | SNV | Missense_Mutation | c.84N>T | p.Glu28Asp | p.E28D | Q9H8V3 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.986) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ECT2 | SNV | Missense_Mutation | c.1304N>G | p.Ser435Cys | p.S435C | Q9H8V3 | protein_coding | deleterious(0.04) | possibly_damaging(0.886) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ECT2 | SNV | Missense_Mutation | novel | c.598N>T | p.His200Tyr | p.H200Y | Q9H8V3 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-VS-A9UO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ECT2 | SNV | Missense_Mutation | rs748437185 | c.1462N>T | p.Arg488Cys | p.R488C | Q9H8V3 | protein_coding | tolerated(0.09) | possibly_damaging(0.806) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ECT2 | SNV | Missense_Mutation | c.2605A>G | p.Ser869Gly | p.S869G | Q9H8V3 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
ECT2 | SNV | Missense_Mutation | c.2607C>A | p.Ser869Arg | p.S869R | Q9H8V3 | protein_coding | tolerated(0.06) | benign(0.07) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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