Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DNAJC3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DNAJC3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/DNAJC3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DNAJC3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/DNAJC3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DNAJC3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DNAJC3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000926622 | Oral cavity | EOLP | response to temperature stimulus | 45/2218 | 178/18723 | 5.23e-07 | 1.40e-05 | 45 |
GO:000644624 | Oral cavity | EOLP | regulation of translational initiation | 25/2218 | 79/18723 | 2.47e-06 | 5.50e-05 | 25 |
GO:005160721 | Oral cavity | EOLP | defense response to virus | 55/2218 | 265/18723 | 2.16e-05 | 3.35e-04 | 55 |
GO:014054621 | Oral cavity | EOLP | defense response to symbiont | 55/2218 | 265/18723 | 2.16e-05 | 3.35e-04 | 55 |
GO:004355521 | Oral cavity | EOLP | regulation of translation in response to stress | 9/2218 | 20/18723 | 2.23e-04 | 2.21e-03 | 9 |
GO:003497524 | Oral cavity | EOLP | protein folding in endoplasmic reticulum | 6/2218 | 11/18723 | 7.46e-04 | 6.03e-03 | 6 |
GO:003649021 | Oral cavity | EOLP | regulation of translation in response to endoplasmic reticulum stress | 6/2218 | 11/18723 | 7.46e-04 | 6.03e-03 | 6 |
GO:001099821 | Oral cavity | EOLP | regulation of translational initiation by eIF2 alpha phosphorylation | 5/2218 | 10/18723 | 3.50e-03 | 2.00e-02 | 5 |
GO:004355821 | Oral cavity | EOLP | regulation of translational initiation in response to stress | 6/2218 | 14/18723 | 3.54e-03 | 2.01e-02 | 6 |
GO:000641333 | Oral cavity | NEOLP | translational initiation | 39/2005 | 118/18723 | 5.20e-11 | 6.30e-09 | 39 |
GO:000641734 | Oral cavity | NEOLP | regulation of translation | 97/2005 | 468/18723 | 9.94e-11 | 1.05e-08 | 97 |
GO:000961531 | Oral cavity | NEOLP | response to virus | 80/2005 | 367/18723 | 3.70e-10 | 3.14e-08 | 80 |
GO:004593633 | Oral cavity | NEOLP | negative regulation of phosphate metabolic process | 88/2005 | 441/18723 | 5.20e-09 | 2.87e-07 | 88 |
GO:001056333 | Oral cavity | NEOLP | negative regulation of phosphorus metabolic process | 88/2005 | 442/18723 | 5.82e-09 | 3.15e-07 | 88 |
GO:004232633 | Oral cavity | NEOLP | negative regulation of phosphorylation | 79/2005 | 385/18723 | 8.76e-09 | 4.48e-07 | 79 |
GO:000193332 | Oral cavity | NEOLP | negative regulation of protein phosphorylation | 70/2005 | 342/18723 | 6.77e-08 | 2.61e-06 | 70 |
GO:003497632 | Oral cavity | NEOLP | response to endoplasmic reticulum stress | 56/2005 | 256/18723 | 1.39e-07 | 4.84e-06 | 56 |
GO:005160731 | Oral cavity | NEOLP | defense response to virus | 57/2005 | 265/18723 | 1.97e-07 | 6.55e-06 | 57 |
GO:014054631 | Oral cavity | NEOLP | defense response to symbiont | 57/2005 | 265/18723 | 1.97e-07 | 6.55e-06 | 57 |
GO:000644631 | Oral cavity | NEOLP | regulation of translational initiation | 25/2005 | 79/18723 | 3.75e-07 | 1.15e-05 | 25 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414139 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa0516420 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa04141114 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa05164110 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0516435 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0516410 | Liver | Cirrhotic | Influenza A | 66/2530 | 171/8465 | 8.56e-03 | 2.91e-02 | 1.79e-02 | 66 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0516411 | Liver | Cirrhotic | Influenza A | 66/2530 | 171/8465 | 8.56e-03 | 2.91e-02 | 1.79e-02 | 66 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0516421 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0516431 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
hsa0414116 | Lung | IAC | Protein processing in endoplasmic reticulum | 37/1053 | 174/8465 | 6.53e-04 | 5.73e-03 | 3.81e-03 | 37 |
hsa0516412 | Lung | IAC | Influenza A | 35/1053 | 171/8465 | 1.82e-03 | 1.00e-02 | 6.66e-03 | 35 |
hsa0414117 | Lung | IAC | Protein processing in endoplasmic reticulum | 37/1053 | 174/8465 | 6.53e-04 | 5.73e-03 | 3.81e-03 | 37 |
hsa0516413 | Lung | IAC | Influenza A | 35/1053 | 171/8465 | 1.82e-03 | 1.00e-02 | 6.66e-03 | 35 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC3 | SNV | Missense_Mutation | | c.1090G>A | p.Glu364Lys | p.E364K | Q13217 | protein_coding | tolerated(0.34) | benign(0.021) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DNAJC3 | SNV | Missense_Mutation | rs533997604 | c.467G>A | p.Arg156His | p.R156H | Q13217 | protein_coding | tolerated(0.22) | benign(0.005) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC3 | SNV | Missense_Mutation | | c.640N>A | p.Ala214Thr | p.A214T | Q13217 | protein_coding | tolerated(0.93) | benign(0.003) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
DNAJC3 | SNV | Missense_Mutation | rs778884455 | c.1423N>A | p.Gly475Ser | p.G475S | Q13217 | protein_coding | tolerated(0.35) | benign(0.124) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
DNAJC3 | SNV | Missense_Mutation | novel | c.337C>G | p.His113Asp | p.H113D | Q13217 | protein_coding | deleterious(0.02) | benign(0.132) | TCGA-E9-A226-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
DNAJC3 | insertion | Frame_Shift_Ins | novel | c.596dupT | p.Glu201ArgfsTer5 | p.E201Rfs*5 | Q13217 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
DNAJC3 | insertion | Nonsense_Mutation | novel | c.597_598insTTGTAAGGCACATTTATATACTTCGACATGTCACATACCAC | p.Lys200LeufsTer2 | p.K200Lfs*2 | Q13217 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
DNAJC3 | SNV | Missense_Mutation | rs144153992 | c.1483G>A | p.Gly495Arg | p.G495R | Q13217 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DNAJC3 | SNV | Missense_Mutation | | c.917T>C | p.Val306Ala | p.V306A | Q13217 | protein_coding | tolerated(0.46) | benign(0) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC3 | SNV | Missense_Mutation | novel | c.82N>A | p.Gly28Ser | p.G28S | Q13217 | protein_coding | tolerated(0.13) | benign(0.013) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |