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Gene: DDRGK1 |
Gene summary for DDRGK1 |
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Gene information | Species | Human | Gene symbol | DDRGK1 | Gene ID | 65992 |
Gene name | DDRGK domain containing 1 | |
Gene Alias | C20orf116 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q96HY6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65992 | DDRGK1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.94e-03 | 1.59e-01 | 0.0155 |
65992 | DDRGK1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.25e-04 | 2.45e-01 | -0.1808 |
65992 | DDRGK1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.89e-12 | 4.02e-01 | -0.0811 |
65992 | DDRGK1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.38e-09 | 2.53e-01 | -0.1954 |
65992 | DDRGK1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.60e-03 | 5.04e-01 | -0.2196 |
65992 | DDRGK1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.08e-02 | 2.27e-01 | -0.1207 |
65992 | DDRGK1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.42e-13 | 3.38e-01 | -0.1464 |
65992 | DDRGK1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.66e-03 | 1.71e-01 | -0.1001 |
65992 | DDRGK1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.64e-14 | 4.43e-01 | -0.059 |
65992 | DDRGK1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.30e-03 | 3.71e-01 | -0.1706 |
65992 | DDRGK1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.99e-04 | 3.33e-01 | -0.2061 |
65992 | DDRGK1 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.35e-13 | 3.61e-01 | 0.096 |
65992 | DDRGK1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.57e-02 | 3.00e-01 | 0.0171 |
65992 | DDRGK1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.36e-08 | 3.41e-01 | 0.0338 |
65992 | DDRGK1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.86e-13 | 3.81e-01 | 0.0674 |
65992 | DDRGK1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.58e-05 | 4.28e-01 | 0.0112 |
65992 | DDRGK1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.67e-04 | 2.18e-01 | 0.294 |
65992 | DDRGK1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.77e-02 | 5.06e-01 | 0.3487 |
65992 | DDRGK1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.11e-08 | 3.50e-01 | 0.281 |
65992 | DDRGK1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.07e-03 | 2.92e-01 | 0.2585 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254712 | Liver | Cirrhotic | regulation of peptidase activity | 185/4634 | 461/18723 | 1.32e-13 | 1.09e-11 | 185 |
GO:001623611 | Liver | Cirrhotic | macroautophagy | 129/4634 | 291/18723 | 1.75e-13 | 1.41e-11 | 129 |
GO:190382912 | Liver | Cirrhotic | positive regulation of cellular protein localization | 123/4634 | 276/18723 | 4.06e-13 | 3.22e-11 | 123 |
GO:190336412 | Liver | Cirrhotic | positive regulation of cellular protein catabolic process | 80/4634 | 155/18723 | 5.04e-13 | 3.86e-11 | 80 |
GO:190305012 | Liver | Cirrhotic | regulation of proteolysis involved in cellular protein catabolic process | 103/4634 | 221/18723 | 1.14e-12 | 8.61e-11 | 103 |
GO:00359677 | Liver | Cirrhotic | cellular response to topologically incorrect protein | 64/4634 | 116/18723 | 2.20e-12 | 1.62e-10 | 64 |
GO:200005812 | Liver | Cirrhotic | regulation of ubiquitin-dependent protein catabolic process | 81/4634 | 164/18723 | 7.22e-12 | 4.92e-10 | 81 |
GO:005109812 | Liver | Cirrhotic | regulation of binding | 148/4634 | 363/18723 | 9.14e-12 | 5.97e-10 | 148 |
GO:00346207 | Liver | Cirrhotic | cellular response to unfolded protein | 54/4634 | 96/18723 | 4.16e-11 | 2.42e-09 | 54 |
GO:00709724 | Liver | Cirrhotic | protein localization to endoplasmic reticulum | 45/4634 | 74/18723 | 4.79e-11 | 2.73e-09 | 45 |
GO:19030084 | Liver | Cirrhotic | organelle disassembly | 59/4634 | 114/18723 | 4.82e-10 | 2.27e-08 | 59 |
GO:00309686 | Liver | Cirrhotic | endoplasmic reticulum unfolded protein response | 43/4634 | 74/18723 | 9.86e-10 | 4.48e-08 | 43 |
GO:007138312 | Liver | Cirrhotic | cellular response to steroid hormone stimulus | 90/4634 | 204/18723 | 1.04e-09 | 4.70e-08 | 90 |
GO:19058977 | Liver | Cirrhotic | regulation of response to endoplasmic reticulum stress | 46/4634 | 82/18723 | 1.28e-09 | 5.56e-08 | 46 |
GO:006113612 | Liver | Cirrhotic | regulation of proteasomal protein catabolic process | 84/4634 | 187/18723 | 1.28e-09 | 5.56e-08 | 84 |
GO:004586112 | Liver | Cirrhotic | negative regulation of proteolysis | 136/4634 | 351/18723 | 3.46e-09 | 1.42e-07 | 136 |
GO:190305211 | Liver | Cirrhotic | positive regulation of proteolysis involved in cellular protein catabolic process | 64/4634 | 133/18723 | 4.23e-09 | 1.70e-07 | 64 |
GO:003243412 | Liver | Cirrhotic | regulation of proteasomal ubiquitin-dependent protein catabolic process | 64/4634 | 134/18723 | 6.16e-09 | 2.40e-07 | 64 |
GO:003052212 | Liver | Cirrhotic | intracellular receptor signaling pathway | 105/4634 | 265/18723 | 5.44e-08 | 1.69e-06 | 105 |
GO:200006012 | Liver | Cirrhotic | positive regulation of ubiquitin-dependent protein catabolic process | 52/4634 | 107/18723 | 7.75e-08 | 2.30e-06 | 52 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDRGK1 | SNV | Missense_Mutation | rs751324528 | c.490N>T | p.Arg164Cys | p.R164C | Q96HY6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDRGK1 | SNV | Missense_Mutation | c.559N>A | p.Glu187Lys | p.E187K | Q96HY6 | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
DDRGK1 | SNV | Missense_Mutation | novel | c.131N>G | p.Ala44Gly | p.A44G | Q96HY6 | protein_coding | tolerated(0.14) | benign(0.027) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DDRGK1 | SNV | Missense_Mutation | c.205G>A | p.Asp69Asn | p.D69N | Q96HY6 | protein_coding | tolerated(1) | benign(0.07) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DDRGK1 | SNV | Missense_Mutation | rs763621314 | c.857N>A | p.Arg286Gln | p.R286Q | Q96HY6 | protein_coding | deleterious(0.02) | benign(0.041) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DDRGK1 | SNV | Missense_Mutation | novel | c.55N>A | p.Leu19Ile | p.L19I | Q96HY6 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDRGK1 | SNV | Missense_Mutation | rs753666292 | c.367C>T | p.Arg123Trp | p.R123W | Q96HY6 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDRGK1 | SNV | Missense_Mutation | c.750N>T | p.Gln250His | p.Q250H | Q96HY6 | protein_coding | tolerated(0.05) | benign(0.202) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
DDRGK1 | SNV | Missense_Mutation | rs764215113 | c.341N>T | p.Ser114Leu | p.S114L | Q96HY6 | protein_coding | deleterious(0.05) | benign(0) | TCGA-AX-A2IO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
DDRGK1 | SNV | Missense_Mutation | novel | c.813N>G | p.Ile271Met | p.I271M | Q96HY6 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
65992 | DDRGK1 | NUCLEAR HORMONE RECEPTOR | azathioprine | AZATHIOPRINE | 21961091 |
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