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Gene: BAIAP2 |
Gene summary for BAIAP2 |
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Gene information | Species | Human | Gene symbol | BAIAP2 | Gene ID | 10458 |
Gene name | BAR/IMD domain containing adaptor protein 2 | |
Gene Alias | BAP2 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9UQB8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10458 | BAIAP2 | LZE4T | Human | Esophagus | ESCC | 2.19e-03 | 9.01e-02 | 0.0811 |
10458 | BAIAP2 | LZE5T | Human | Esophagus | ESCC | 2.29e-06 | 2.65e-01 | 0.0514 |
10458 | BAIAP2 | LZE7T | Human | Esophagus | ESCC | 1.80e-02 | 4.83e-01 | 0.0667 |
10458 | BAIAP2 | LZE8T | Human | Esophagus | ESCC | 5.61e-08 | 5.85e-01 | 0.067 |
10458 | BAIAP2 | LZE22T | Human | Esophagus | ESCC | 1.98e-06 | 9.14e-01 | 0.068 |
10458 | BAIAP2 | LZE24T | Human | Esophagus | ESCC | 1.83e-08 | 6.31e-01 | 0.0596 |
10458 | BAIAP2 | LZE21T | Human | Esophagus | ESCC | 9.38e-08 | 1.22e+00 | 0.0655 |
10458 | BAIAP2 | P1T-E | Human | Esophagus | ESCC | 1.78e-06 | 8.14e-01 | 0.0875 |
10458 | BAIAP2 | P2T-E | Human | Esophagus | ESCC | 1.86e-14 | 1.30e-01 | 0.1177 |
10458 | BAIAP2 | P4T-E | Human | Esophagus | ESCC | 1.19e-08 | 2.83e-01 | 0.1323 |
10458 | BAIAP2 | P5T-E | Human | Esophagus | ESCC | 2.48e-19 | 5.97e-01 | 0.1327 |
10458 | BAIAP2 | P8T-E | Human | Esophagus | ESCC | 3.13e-20 | 1.88e-01 | 0.0889 |
10458 | BAIAP2 | P9T-E | Human | Esophagus | ESCC | 3.91e-15 | 5.99e-01 | 0.1131 |
10458 | BAIAP2 | P10T-E | Human | Esophagus | ESCC | 2.61e-35 | 7.09e-01 | 0.116 |
10458 | BAIAP2 | P11T-E | Human | Esophagus | ESCC | 5.07e-26 | 1.99e+00 | 0.1426 |
10458 | BAIAP2 | P12T-E | Human | Esophagus | ESCC | 3.83e-46 | 1.38e+00 | 0.1122 |
10458 | BAIAP2 | P15T-E | Human | Esophagus | ESCC | 8.32e-28 | 7.52e-01 | 0.1149 |
10458 | BAIAP2 | P16T-E | Human | Esophagus | ESCC | 2.69e-24 | -1.14e-02 | 0.1153 |
10458 | BAIAP2 | P17T-E | Human | Esophagus | ESCC | 1.44e-05 | 5.54e-01 | 0.1278 |
10458 | BAIAP2 | P20T-E | Human | Esophagus | ESCC | 1.46e-68 | 2.54e+00 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000836018 | Esophagus | ESCC | regulation of cell shape | 92/8552 | 154/18723 | 3.00e-04 | 1.81e-03 | 92 |
GO:001076920 | Esophagus | ESCC | regulation of cell morphogenesis involved in differentiation | 61/8552 | 96/18723 | 3.12e-04 | 1.85e-03 | 61 |
GO:00712296 | Esophagus | ESCC | cellular response to acid chemical | 52/8552 | 80/18723 | 3.79e-04 | 2.20e-03 | 52 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:001077018 | Esophagus | ESCC | positive regulation of cell morphogenesis involved in differentiation | 51/8552 | 79/18723 | 5.48e-04 | 3.00e-03 | 51 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:19020651 | Esophagus | ESCC | response to L-glutamate | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
GO:00109764 | Esophagus | ESCC | positive regulation of neuron projection development | 91/8552 | 163/18723 | 5.72e-03 | 2.13e-02 | 91 |
GO:20002497 | Esophagus | ESCC | regulation of actin cytoskeleton reorganization | 26/8552 | 39/18723 | 6.63e-03 | 2.43e-02 | 26 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
GO:00995635 | Esophagus | ESCC | modification of synaptic structure | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
GO:00082869 | Esophagus | ESCC | insulin receptor signaling pathway | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:003286821 | Liver | HCC | response to insulin | 172/7958 | 264/18723 | 7.14e-14 | 4.23e-12 | 172 |
GO:003286921 | Liver | HCC | cellular response to insulin stimulus | 137/7958 | 203/18723 | 4.69e-13 | 2.44e-11 | 137 |
GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
GO:007137521 | Liver | HCC | cellular response to peptide hormone stimulus | 179/7958 | 290/18723 | 2.54e-11 | 9.88e-10 | 179 |
GO:005125822 | Liver | HCC | protein polymerization | 182/7958 | 297/18723 | 4.17e-11 | 1.58e-09 | 182 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0513526 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0481028 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa05130310 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa05135111 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04810112 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0452042 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0513542 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0513052 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0452052 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0513552 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0513030 | Oral cavity | OSCC | Pathogenic Escherichia coli infection | 129/3704 | 197/8465 | 4.32e-10 | 5.17e-09 | 2.63e-09 | 129 |
hsa0513520 | Oral cavity | OSCC | Yersinia infection | 94/3704 | 137/8465 | 2.85e-09 | 3.08e-08 | 1.57e-08 | 94 |
hsa0452029 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa0481026 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAIAP2 | SNV | Missense_Mutation | novel | c.1307N>T | p.Asp436Val | p.D436V | Q9UQB8 | protein_coding | deleterious(0.05) | benign(0.05) | TCGA-A2-A4S3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BAIAP2 | SNV | Missense_Mutation | novel | c.1146N>G | p.Ile382Met | p.I382M | Q9UQB8 | protein_coding | tolerated(0.06) | possibly_damaging(0.455) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
BAIAP2 | insertion | Frame_Shift_Ins | novel | c.1251_1252insCCTCAGAACCCTGTGATGATTGCGTTAACTGCACAAATTGTTC | p.Ser418ProfsTer16 | p.S418Pfs*16 | Q9UQB8 | protein_coding | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
BAIAP2 | SNV | Missense_Mutation | novel | c.460N>T | p.Pro154Ser | p.P154S | Q9UQB8 | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAIAP2 | SNV | Missense_Mutation | novel | c.1289N>T | p.Ser430Phe | p.S430F | Q9UQB8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9U7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAIAP2 | SNV | Missense_Mutation | c.1229N>A | p.Arg410His | p.R410H | Q9UQB8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5659-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BAIAP2 | SNV | Missense_Mutation | novel | c.1269N>T | p.Met423Ile | p.M423I | Q9UQB8 | protein_coding | tolerated(0.1) | benign(0.018) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
BAIAP2 | SNV | Missense_Mutation | rs760359913 | c.1552N>A | p.Val518Ile | p.V518I | Q9UQB8 | protein_coding | tolerated(0.1) | benign(0.023) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
BAIAP2 | SNV | Missense_Mutation | c.314N>C | p.Leu105Pro | p.L105P | Q9UQB8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
BAIAP2 | SNV | Missense_Mutation | rs768070859 | c.1408N>A | p.Asp470Asn | p.D470N | Q9UQB8 | protein_coding | deleterious(0) | benign(0.109) | TCGA-CM-4752-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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