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Gene: ADIPOR1 |
Gene summary for ADIPOR1 |
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Gene information | Species | Human | Gene symbol | ADIPOR1 | Gene ID | 51094 |
Gene name | adiponectin receptor 1 | |
Gene Alias | ACDCR1 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q96A54 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51094 | ADIPOR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.96e-02 | 2.24e-01 | -0.1808 |
51094 | ADIPOR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.27e-03 | 2.51e-01 | -0.0811 |
51094 | ADIPOR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.77e-08 | 4.21e-01 | -0.1088 |
51094 | ADIPOR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.17e-09 | 2.96e-01 | -0.1954 |
51094 | ADIPOR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.47e-06 | 3.15e-01 | -0.059 |
51094 | ADIPOR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.97e-02 | 3.22e-01 | -0.1706 |
51094 | ADIPOR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.07e-06 | 1.82e-01 | 0.096 |
51094 | ADIPOR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.25e-02 | 1.99e-01 | 0.0674 |
51094 | ADIPOR1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.02e-04 | 3.49e-01 | 0.0588 |
51094 | ADIPOR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.47e-08 | 3.17e-01 | 0.294 |
51094 | ADIPOR1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.88e-02 | 5.32e-01 | 0.3487 |
51094 | ADIPOR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.54e-09 | 4.72e-01 | 0.281 |
51094 | ADIPOR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.06e-12 | 4.52e-01 | 0.3859 |
51094 | ADIPOR1 | LZE3D | Human | Esophagus | HGIN | 4.56e-07 | 3.14e-01 | 0.0668 |
51094 | ADIPOR1 | LZE4T | Human | Esophagus | ESCC | 1.28e-06 | 4.48e-01 | 0.0811 |
51094 | ADIPOR1 | LZE7T | Human | Esophagus | ESCC | 1.95e-05 | 8.58e-01 | 0.0667 |
51094 | ADIPOR1 | LZE20T | Human | Esophagus | ESCC | 9.37e-05 | 3.56e-01 | 0.0662 |
51094 | ADIPOR1 | LZE22T | Human | Esophagus | ESCC | 7.21e-03 | 1.05e+00 | 0.068 |
51094 | ADIPOR1 | LZE24T | Human | Esophagus | ESCC | 1.70e-18 | 1.04e+00 | 0.0596 |
51094 | ADIPOR1 | LZE21T | Human | Esophagus | ESCC | 1.41e-03 | 1.33e-01 | 0.0655 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190122211 | Prostate | Tumor | regulation of NIK/NF-kappaB signaling | 34/3246 | 112/18723 | 4.92e-04 | 3.64e-03 | 34 |
GO:003033613 | Prostate | Tumor | negative regulation of cell migration | 84/3246 | 344/18723 | 4.95e-04 | 3.66e-03 | 84 |
GO:000828614 | Prostate | Tumor | insulin receptor signaling pathway | 34/3246 | 116/18723 | 9.83e-04 | 6.36e-03 | 34 |
GO:003030811 | Prostate | Tumor | negative regulation of cell growth | 49/3246 | 188/18723 | 1.65e-03 | 9.87e-03 | 49 |
GO:00193187 | Prostate | Tumor | hexose metabolic process | 59/3246 | 237/18723 | 1.96e-03 | 1.14e-02 | 59 |
GO:001067511 | Prostate | Tumor | regulation of cellular carbohydrate metabolic process | 39/3246 | 146/18723 | 2.93e-03 | 1.58e-02 | 39 |
GO:001090611 | Prostate | Tumor | regulation of glucose metabolic process | 33/3246 | 119/18723 | 3.13e-03 | 1.65e-02 | 33 |
GO:01201623 | Prostate | Tumor | positive regulation of cold-induced thermogenesis | 28/3246 | 97/18723 | 3.35e-03 | 1.74e-02 | 28 |
GO:00059967 | Prostate | Tumor | monosaccharide metabolic process | 62/3246 | 257/18723 | 3.38e-03 | 1.75e-02 | 62 |
GO:19908453 | Prostate | Tumor | adaptive thermogenesis | 41/3246 | 157/18723 | 3.63e-03 | 1.86e-02 | 41 |
GO:00192166 | Prostate | Tumor | regulation of lipid metabolic process | 76/3246 | 331/18723 | 5.04e-03 | 2.45e-02 | 76 |
GO:00016593 | Prostate | Tumor | temperature homeostasis | 44/3246 | 174/18723 | 5.04e-03 | 2.45e-02 | 44 |
GO:004426212 | Prostate | Tumor | cellular carbohydrate metabolic process | 66/3246 | 283/18723 | 5.90e-03 | 2.74e-02 | 66 |
GO:01061064 | Prostate | Tumor | cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
GO:01201614 | Prostate | Tumor | regulation of cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
GO:001604925 | Skin | cSCC | cell growth | 173/4864 | 482/18723 | 7.21e-07 | 1.34e-05 | 173 |
GO:004343426 | Skin | cSCC | response to peptide hormone | 150/4864 | 414/18723 | 2.11e-06 | 3.43e-05 | 150 |
GO:007137518 | Skin | cSCC | cellular response to peptide hormone stimulus | 104/4864 | 290/18723 | 1.15e-04 | 1.06e-03 | 104 |
GO:1901653110 | Skin | cSCC | cellular response to peptide | 124/4864 | 359/18723 | 1.75e-04 | 1.49e-03 | 124 |
GO:000975518 | Skin | cSCC | hormone-mediated signaling pathway | 72/4864 | 190/18723 | 1.92e-04 | 1.61e-03 | 72 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04211 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa042111 | Colorectum | AD | Longevity regulating pathway | 33/2092 | 89/8465 | 6.15e-03 | 2.68e-02 | 1.71e-02 | 33 |
hsa042112 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
hsa041522 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa042113 | Colorectum | MSS | Longevity regulating pathway | 33/1875 | 89/8465 | 9.33e-04 | 5.58e-03 | 3.42e-03 | 33 |
hsa041523 | Colorectum | MSS | AMPK signaling pathway | 41/1875 | 121/8465 | 1.91e-03 | 9.83e-03 | 6.03e-03 | 41 |
hsa04932210 | Esophagus | ESCC | Non-alcoholic fatty liver disease | 122/4205 | 155/8465 | 5.69e-14 | 1.59e-12 | 8.14e-13 | 122 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa0421114 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0493238 | Esophagus | ESCC | Non-alcoholic fatty liver disease | 122/4205 | 155/8465 | 5.69e-14 | 1.59e-12 | 8.14e-13 | 122 |
hsa0415213 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa0421115 | Esophagus | ESCC | Longevity regulating pathway | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0493222 | Liver | Cirrhotic | Non-alcoholic fatty liver disease | 106/2530 | 155/8465 | 2.16e-23 | 2.40e-21 | 1.48e-21 | 106 |
hsa04936 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
hsa0415221 | Liver | Cirrhotic | AMPK signaling pathway | 49/2530 | 121/8465 | 7.90e-03 | 2.74e-02 | 1.69e-02 | 49 |
hsa042118 | Liver | Cirrhotic | Longevity regulating pathway | 37/2530 | 89/8465 | 1.22e-02 | 3.89e-02 | 2.40e-02 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADIPOR1 | SNV | Missense_Mutation | novel | c.824N>A | p.Gly275Asp | p.G275D | Q96A54 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ADIPOR1 | SNV | Missense_Mutation | c.167T>C | p.Val56Ala | p.V56A | Q96A54 | protein_coding | tolerated(0.89) | benign(0) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
ADIPOR1 | SNV | Missense_Mutation | novel | c.559N>C | p.Ser187Pro | p.S187P | Q96A54 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR |
ADIPOR1 | SNV | Missense_Mutation | novel | c.648T>G | p.Ile216Met | p.I216M | Q96A54 | protein_coding | deleterious(0.04) | possibly_damaging(0.706) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ADIPOR1 | SNV | Missense_Mutation | c.296T>C | p.Val99Ala | p.V99A | Q96A54 | protein_coding | tolerated(0.52) | benign(0) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADIPOR1 | SNV | Missense_Mutation | novel | c.605G>A | p.Arg202Gln | p.R202Q | Q96A54 | protein_coding | tolerated(0.09) | benign(0.025) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADIPOR1 | SNV | Missense_Mutation | novel | c.677N>G | p.Tyr226Cys | p.Y226C | Q96A54 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADIPOR1 | SNV | Missense_Mutation | novel | c.493N>T | p.Ala165Ser | p.A165S | Q96A54 | protein_coding | tolerated(0.19) | benign(0.199) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ADIPOR1 | SNV | Missense_Mutation | novel | c.226G>A | p.Ala76Thr | p.A76T | Q96A54 | protein_coding | tolerated(0.08) | possibly_damaging(0.701) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
ADIPOR1 | SNV | Missense_Mutation | novel | c.797C>T | p.Thr266Ile | p.T266I | Q96A54 | protein_coding | tolerated(0.38) | benign(0.017) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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