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Gene: ZBTB2 |
Gene summary for ZBTB2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZBTB2 | Gene ID | 57621 |
| Gene name | zinc finger and BTB domain containing 2 | |
| Gene Alias | ZNF437 | |
| Cytomap | 6q25.1 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8N680 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57621 | ZBTB2 | LZE4T | Human | Esophagus | ESCC | 2.05e-03 | -1.19e-02 | 0.0811 |
| 57621 | ZBTB2 | LZE24T | Human | Esophagus | ESCC | 6.19e-08 | 1.22e-01 | 0.0596 |
| 57621 | ZBTB2 | P2T-E | Human | Esophagus | ESCC | 6.30e-07 | 8.50e-02 | 0.1177 |
| 57621 | ZBTB2 | P4T-E | Human | Esophagus | ESCC | 1.18e-06 | 1.79e-01 | 0.1323 |
| 57621 | ZBTB2 | P5T-E | Human | Esophagus | ESCC | 2.68e-10 | 2.87e-02 | 0.1327 |
| 57621 | ZBTB2 | P8T-E | Human | Esophagus | ESCC | 6.28e-07 | 8.27e-02 | 0.0889 |
| 57621 | ZBTB2 | P9T-E | Human | Esophagus | ESCC | 5.84e-04 | 5.82e-03 | 0.1131 |
| 57621 | ZBTB2 | P10T-E | Human | Esophagus | ESCC | 8.27e-06 | -5.79e-02 | 0.116 |
| 57621 | ZBTB2 | P11T-E | Human | Esophagus | ESCC | 6.25e-03 | 3.35e-01 | 0.1426 |
| 57621 | ZBTB2 | P15T-E | Human | Esophagus | ESCC | 6.17e-07 | 2.33e-01 | 0.1149 |
| 57621 | ZBTB2 | P16T-E | Human | Esophagus | ESCC | 2.73e-05 | 1.31e-01 | 0.1153 |
| 57621 | ZBTB2 | P17T-E | Human | Esophagus | ESCC | 1.15e-02 | 3.08e-02 | 0.1278 |
| 57621 | ZBTB2 | P19T-E | Human | Esophagus | ESCC | 3.19e-02 | 1.39e-01 | 0.1662 |
| 57621 | ZBTB2 | P20T-E | Human | Esophagus | ESCC | 3.10e-06 | 9.51e-03 | 0.1124 |
| 57621 | ZBTB2 | P21T-E | Human | Esophagus | ESCC | 3.71e-15 | 6.86e-02 | 0.1617 |
| 57621 | ZBTB2 | P22T-E | Human | Esophagus | ESCC | 4.90e-07 | -1.54e-02 | 0.1236 |
| 57621 | ZBTB2 | P23T-E | Human | Esophagus | ESCC | 7.13e-07 | 3.71e-01 | 0.108 |
| 57621 | ZBTB2 | P24T-E | Human | Esophagus | ESCC | 3.62e-02 | 7.71e-02 | 0.1287 |
| 57621 | ZBTB2 | P26T-E | Human | Esophagus | ESCC | 6.77e-05 | 2.36e-01 | 0.1276 |
| 57621 | ZBTB2 | P27T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.12e-01 | 0.1055 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00460312 | Colorectum | MSS | ADP metabolic process | 33/3467 | 90/18723 | 3.70e-05 | 7.09e-04 | 33 |
| GO:00713312 | Colorectum | MSS | cellular response to hexose stimulus | 49/3467 | 153/18723 | 4.01e-05 | 7.61e-04 | 49 |
| GO:00060902 | Colorectum | MSS | pyruvate metabolic process | 37/3467 | 106/18723 | 4.48e-05 | 8.28e-04 | 37 |
| GO:00713262 | Colorectum | MSS | cellular response to monosaccharide stimulus | 49/3467 | 154/18723 | 4.84e-05 | 8.80e-04 | 49 |
| GO:00060962 | Colorectum | MSS | glycolytic process | 30/3467 | 81/18723 | 6.61e-05 | 1.15e-03 | 30 |
| GO:00091322 | Colorectum | MSS | nucleoside diphosphate metabolic process | 41/3467 | 124/18723 | 7.44e-05 | 1.24e-03 | 41 |
| GO:00067572 | Colorectum | MSS | ATP generation from ADP | 30/3467 | 82/18723 | 8.59e-05 | 1.39e-03 | 30 |
| GO:00469392 | Colorectum | MSS | nucleotide phosphorylation | 33/3467 | 101/18723 | 4.57e-04 | 5.43e-03 | 33 |
| GO:00061101 | Colorectum | MSS | regulation of glycolytic process | 18/3467 | 45/18723 | 6.38e-04 | 6.99e-03 | 18 |
| GO:00434701 | Colorectum | MSS | regulation of carbohydrate catabolic process | 21/3467 | 56/18723 | 6.51e-04 | 7.06e-03 | 21 |
| GO:00061652 | Colorectum | MSS | nucleoside diphosphate phosphorylation | 32/3467 | 99/18723 | 6.83e-04 | 7.37e-03 | 32 |
| GO:00160522 | Colorectum | MSS | carbohydrate catabolic process | 45/3467 | 154/18723 | 7.93e-04 | 8.36e-03 | 45 |
| GO:19035801 | Colorectum | MSS | positive regulation of ATP metabolic process | 15/3467 | 38/18723 | 2.07e-03 | 1.76e-02 | 15 |
| GO:00620121 | Colorectum | MSS | regulation of small molecule metabolic process | 83/3467 | 334/18723 | 2.25e-03 | 1.85e-02 | 83 |
| GO:00459811 | Colorectum | MSS | positive regulation of nucleotide metabolic process | 16/3467 | 43/18723 | 3.04e-03 | 2.33e-02 | 16 |
| GO:19005441 | Colorectum | MSS | positive regulation of purine nucleotide metabolic process | 16/3467 | 43/18723 | 3.04e-03 | 2.33e-02 | 16 |
| GO:00061091 | Colorectum | MSS | regulation of carbohydrate metabolic process | 47/3467 | 178/18723 | 5.75e-03 | 3.90e-02 | 47 |
| GO:0062013 | Colorectum | MSS | positive regulation of small molecule metabolic process | 39/3467 | 143/18723 | 6.34e-03 | 4.23e-02 | 39 |
| GO:1900542 | Colorectum | MSS | regulation of purine nucleotide metabolic process | 25/3467 | 84/18723 | 8.27e-03 | 4.99e-02 | 25 |
| GO:00460343 | Colorectum | MSI-H | ATP metabolic process | 71/1319 | 277/18723 | 3.18e-22 | 8.32e-19 | 71 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZBTB2 | MYOFIB | Colorectum | CRC | EMCN,SPTLC2,NUAK1, etc. | 2.89e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZBTB2 | SNV | Missense_Mutation | c.764N>T | p.Ala255Val | p.A255V | Q8N680 | protein_coding | tolerated(0.98) | benign(0.07) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZBTB2 | SNV | Missense_Mutation | c.233N>G | p.His78Arg | p.H78R | Q8N680 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-AR-A1AW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | |
| ZBTB2 | SNV | Missense_Mutation | c.406C>G | p.Gln136Glu | p.Q136E | Q8N680 | protein_coding | deleterious(0) | possibly_damaging(0.622) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| ZBTB2 | SNV | Missense_Mutation | c.239N>A | p.Met80Lys | p.M80K | Q8N680 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-D8-A1XZ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen+anastrozolum | SD | |
| ZBTB2 | SNV | Missense_Mutation | c.629N>G | p.Pro210Arg | p.P210R | Q8N680 | protein_coding | tolerated(0.58) | benign(0.044) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZBTB2 | SNV | Missense_Mutation | c.28N>G | p.Leu10Val | p.L10V | Q8N680 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| ZBTB2 | insertion | Frame_Shift_Ins | novel | c.823_824insCGAAGGGCGATCCATTCTCCTGGGC | p.Ile275ThrfsTer18 | p.I275Tfs*18 | Q8N680 | protein_coding | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
| ZBTB2 | SNV | Missense_Mutation | c.602N>T | p.Ser201Leu | p.S201L | Q8N680 | protein_coding | tolerated(0.22) | benign(0.144) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
| ZBTB2 | SNV | Missense_Mutation | rs762417728 | c.635C>T | p.Pro212Leu | p.P212L | Q8N680 | protein_coding | tolerated(0.33) | benign(0.025) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| ZBTB2 | SNV | Missense_Mutation | rs191541534 | c.340N>A | p.Ala114Thr | p.A114T | Q8N680 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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