Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TNFRSF21_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TNFRSF21_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TNFRSF21_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/TNFRSF21_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TNFRSF21_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/TNFRSF21_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TNFRSF21_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/TNFRSF21_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TNFRSF21_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00421292 | Stomach | CSG | regulation of T cell proliferation | 19/1034 | 171/18723 | 2.91e-03 | 2.74e-02 | 19 |
GO:00508512 | Stomach | CSG | antigen receptor-mediated signaling pathway | 24/1034 | 240/18723 | 3.65e-03 | 3.26e-02 | 24 |
GO:00466512 | Stomach | CSG | lymphocyte proliferation | 27/1034 | 288/18723 | 5.17e-03 | 4.19e-02 | 27 |
GO:00022531 | Stomach | CSG | activation of immune response | 33/1034 | 375/18723 | 5.70e-03 | 4.54e-02 | 33 |
GO:00329431 | Stomach | CSG | mononuclear cell proliferation | 27/1034 | 291/18723 | 5.93e-03 | 4.66e-02 | 27 |
GO:007099731 | Stomach | CAG | neuron death | 27/552 | 361/18723 | 1.01e-05 | 4.15e-04 | 27 |
GO:00224073 | Stomach | CAG | regulation of cell-cell adhesion | 31/552 | 448/18723 | 1.08e-05 | 4.42e-04 | 31 |
GO:00713563 | Stomach | CAG | cellular response to tumor necrosis factor | 19/552 | 229/18723 | 5.18e-05 | 1.55e-03 | 19 |
GO:00346123 | Stomach | CAG | response to tumor necrosis factor | 20/552 | 253/18723 | 6.54e-05 | 1.85e-03 | 20 |
GO:005140231 | Stomach | CAG | neuron apoptotic process | 19/552 | 246/18723 | 1.34e-04 | 3.22e-03 | 19 |
GO:00706613 | Stomach | CAG | leukocyte proliferation | 22/552 | 318/18723 | 2.03e-04 | 4.32e-03 | 22 |
GO:00071593 | Stomach | CAG | leukocyte cell-cell adhesion | 24/552 | 371/18723 | 2.90e-04 | 5.53e-03 | 24 |
GO:19030373 | Stomach | CAG | regulation of leukocyte cell-cell adhesion | 22/552 | 336/18723 | 4.35e-04 | 7.55e-03 | 22 |
GO:00026833 | Stomach | CAG | negative regulation of immune system process | 26/552 | 434/18723 | 5.35e-04 | 8.98e-03 | 26 |
GO:000716211 | Stomach | CAG | negative regulation of cell adhesion | 20/552 | 303/18723 | 7.06e-04 | 1.11e-02 | 20 |
GO:00224081 | Stomach | CAG | negative regulation of cell-cell adhesion | 15/552 | 196/18723 | 7.30e-04 | 1.13e-02 | 15 |
GO:00508633 | Stomach | CAG | regulation of T cell activation | 21/552 | 329/18723 | 8.08e-04 | 1.22e-02 | 21 |
GO:00706633 | Stomach | CAG | regulation of leukocyte proliferation | 17/552 | 245/18723 | 1.01e-03 | 1.43e-02 | 17 |
GO:00069593 | Stomach | CAG | humoral immune response | 20/552 | 317/18723 | 1.23e-03 | 1.63e-02 | 20 |
GO:00421103 | Stomach | CAG | T cell activation | 27/552 | 487/18723 | 1.34e-03 | 1.74e-02 | 27 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF21 | SNV | Missense_Mutation | | c.1600N>A | p.Ala534Thr | p.A534T | O75509 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
TNFRSF21 | insertion | In_Frame_Ins | novel | c.420_421insTATACCAAAGATGTTTTCTCCATTTCGTGTATTCCAAAG | p.Ser140_Asn141insTyrThrLysAspValPheSerIleSerCysIleProLys | p.S140_N141insYTKDVFSISCIPK | O75509 | protein_coding | | | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
TNFRSF21 | insertion | Frame_Shift_Ins | novel | c.1319_1320insACACACACACACACGCATACGCCTGCACA | p.Ser441HisfsTer48 | p.S441Hfs*48 | O75509 | protein_coding | | | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TNFRSF21 | SNV | Missense_Mutation | rs781439087 | c.1414G>A | p.Glu472Lys | p.E472K | O75509 | protein_coding | deleterious(0.01) | benign(0.266) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNFRSF21 | SNV | Missense_Mutation | | c.1224N>G | p.Ile408Met | p.I408M | O75509 | protein_coding | deleterious(0.04) | possibly_damaging(0.779) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | | c.1036N>G | p.Ile346Val | p.I346V | O75509 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EK-A2RE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | rs778427574 | c.1769N>A | p.Arg590His | p.R590H | O75509 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | | c.1376N>T | p.Ala459Val | p.A459V | O75509 | protein_coding | deleterious(0) | possibly_damaging(0.64) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF21 | SNV | Missense_Mutation | rs867596127 | c.1483N>T | p.Arg495Cys | p.R495C | O75509 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TNFRSF21 | SNV | Missense_Mutation | | c.1363G>A | p.Asp455Asn | p.D455N | O75509 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |