Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SLC25A13

Gene summary for SLC25A13

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SLC25A13

Gene ID

10165

Gene namesolute carrier family 25 member 13
Gene AliasARALAR2
Cytomap7q21.3
Gene Typeprotein-coding
GO ID

GO:0003333

UniProtAcc

Q9UJS0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10165SLC25A13CCI_1HumanCervixCC1.72e-037.30e-010.528
10165SLC25A13CCI_3HumanCervixCC4.56e-065.80e-010.516
10165SLC25A13HTA11_3410_2000001011HumanColorectumAD4.63e-17-6.04e-010.0155
10165SLC25A13HTA11_1938_2000001011HumanColorectumAD3.00e-03-3.07e-01-0.0811
10165SLC25A13HTA11_696_2000001011HumanColorectumAD2.49e-04-3.67e-01-0.1464
10165SLC25A13HTA11_7862_2000001011HumanColorectumAD2.45e-04-5.92e-01-0.0179
10165SLC25A13HTA11_866_3004761011HumanColorectumAD4.00e-05-4.34e-010.096
10165SLC25A13HTA11_9408_2000001011HumanColorectumAD4.89e-02-8.14e-010.0451
10165SLC25A13HTA11_10711_2000001011HumanColorectumAD2.15e-03-4.52e-010.0338
10165SLC25A13HTA11_7696_3000711011HumanColorectumAD5.31e-17-5.26e-010.0674
10165SLC25A13HTA11_99999965104_69814HumanColorectumMSS6.75e-034.93e-010.281
10165SLC25A13HTA11_99999974143_84620HumanColorectumMSS8.83e-04-3.79e-010.3005
10165SLC25A13F007HumanColorectumFAP1.13e-05-4.86e-010.1176
10165SLC25A13A015-C-203HumanColorectumFAP7.56e-32-5.51e-01-0.1294
10165SLC25A13A015-C-204HumanColorectumFAP1.86e-08-4.68e-01-0.0228
10165SLC25A13A014-C-040HumanColorectumFAP5.02e-05-4.88e-01-0.1184
10165SLC25A13A002-C-201HumanColorectumFAP3.26e-17-5.17e-010.0324
10165SLC25A13A001-C-119HumanColorectumFAP9.42e-06-4.27e-01-0.1557
10165SLC25A13A001-C-108HumanColorectumFAP8.29e-20-4.58e-01-0.0272
10165SLC25A13A002-C-205HumanColorectumFAP2.57e-23-5.17e-01-0.1236
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000925912LiverCirrhoticribonucleotide metabolic process151/4634385/187231.72e-108.70e-09151
GO:007252112LiverCirrhoticpurine-containing compound metabolic process156/4634416/187233.74e-091.52e-07156
GO:000915012LiverCirrhoticpurine ribonucleotide metabolic process141/4634368/187234.22e-091.70e-07141
GO:000599612LiverCirrhoticmonosaccharide metabolic process104/4634257/187231.74e-086.32e-07104
GO:001931812LiverCirrhotichexose metabolic process97/4634237/187232.67e-089.16e-0797
GO:000616312LiverCirrhoticpurine nucleotide metabolic process146/4634396/187234.12e-081.34e-06146
GO:19016051LiverCirrhoticalpha-amino acid metabolic process82/4634195/187237.72e-082.30e-0682
GO:000600611LiverCirrhoticglucose metabolic process82/4634196/187231.01e-072.93e-0682
GO:000652011LiverCirrhoticcellular amino acid metabolic process103/4634284/187238.88e-061.30e-04103
GO:005159211LiverCirrhoticresponse to calcium ion61/4634149/187239.47e-061.38e-0461
GO:00463641LiverCirrhoticmonosaccharide biosynthetic process37/463482/187234.52e-055.30e-0437
GO:00463905LiverCirrhoticribose phosphate biosynthetic process71/4634190/187237.09e-057.98e-0471
GO:00092605LiverCirrhoticribonucleotide biosynthetic process68/4634182/187231.00e-041.05e-0368
GO:00091654LiverCirrhoticnucleotide biosynthetic process89/4634254/187231.45e-041.40e-0389
GO:00160511LiverCirrhoticcarbohydrate biosynthetic process73/4634202/187231.91e-041.77e-0373
GO:19012934LiverCirrhoticnucleoside phosphate biosynthetic process89/4634256/187231.97e-041.82e-0389
GO:00091526LiverCirrhoticpurine ribonucleotide biosynthetic process62/4634169/187233.52e-043.00e-0362
GO:19905425LiverCirrhoticmitochondrial transmembrane transport41/4634102/187234.08e-043.37e-0341
GO:00193191LiverCirrhotichexose biosynthetic process33/463478/187234.94e-043.96e-0333
GO:00060941LiverCirrhoticgluconeogenesis32/463475/187235.00e-043.98e-0332
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SLC25A13SNVMissense_Mutationrs376257669c.572N>Ap.Arg191Hisp.R191HQ9UJS0protein_codingdeleterious(0.02)benign(0.049)TCGA-A2-A0CT-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
SLC25A13SNVMissense_Mutationc.874N>Gp.Arg292Glyp.R292GQ9UJS0protein_codingtolerated(0.06)benign(0.081)TCGA-A7-A26G-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
SLC25A13SNVMissense_Mutationrs142308242c.874N>Tp.Arg292Trpp.R292WQ9UJS0protein_codingdeleterious(0)possibly_damaging(0.586)TCGA-AR-A0TU-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificDoxorubicinSD
SLC25A13SNVMissense_Mutationc.1460N>Tp.Ala487Valp.A487VQ9UJS0protein_codingtolerated(0.06)probably_damaging(0.933)TCGA-E2-A1L9-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
SLC25A13insertionFrame_Shift_Insnovelc.943_944insTTATGTACp.Ser315PhefsTer42p.S315Ffs*42Q9UJS0protein_codingTCGA-AN-A04C-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SLC25A13insertionNonsense_Mutationnovelc.941_942insATATTTCTGAGACTCAGTATTATCACp.Ser315TyrfsTer3p.S315Yfs*3Q9UJS0protein_codingTCGA-AN-A04C-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SLC25A13SNVMissense_Mutationnovelc.690G>Ap.Met230Ilep.M230IQ9UJS0protein_codingtolerated(0.09)benign(0.222)TCGA-C5-A7X5-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycarboplatinPD
SLC25A13SNVMissense_Mutationc.871N>Ap.Glu291Lysp.E291KQ9UJS0protein_codingtolerated(0.08)benign(0.058)TCGA-UC-A7PF-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SLC25A13SNVMissense_Mutationc.1001G>Ap.Gly334Aspp.G334DQ9UJS0protein_codingtolerated(0.27)benign(0.088)TCGA-A6-3810-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
SLC25A13SNVMissense_Mutationc.2010N>Tp.Lys670Asnp.K670NQ9UJS0protein_codingtolerated_low_confidence(0.45)benign(0.01)TCGA-AA-3811-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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