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Gene: SIRT6 |
Gene summary for SIRT6 |
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Gene information | Species | Human | Gene symbol | SIRT6 | Gene ID | 51548 |
Gene name | sirtuin 6 | |
Gene Alias | SIR2L6 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q8N6T7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51548 | SIRT6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.24e-14 | 5.57e-01 | -0.1808 |
51548 | SIRT6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.52e-03 | 3.31e-01 | -0.1207 |
51548 | SIRT6 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.78e-04 | 3.44e-01 | -0.1464 |
51548 | SIRT6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.60e-02 | 2.35e-01 | -0.059 |
51548 | SIRT6 | LZE4T | Human | Esophagus | ESCC | 3.93e-05 | 1.43e-01 | 0.0811 |
51548 | SIRT6 | LZE7T | Human | Esophagus | ESCC | 1.32e-06 | 3.05e-01 | 0.0667 |
51548 | SIRT6 | LZE8T | Human | Esophagus | ESCC | 1.29e-04 | 1.82e-01 | 0.067 |
51548 | SIRT6 | LZE20T | Human | Esophagus | ESCC | 4.56e-08 | 1.46e-01 | 0.0662 |
51548 | SIRT6 | LZE22T | Human | Esophagus | ESCC | 3.34e-02 | 2.51e-01 | 0.068 |
51548 | SIRT6 | LZE24T | Human | Esophagus | ESCC | 7.12e-09 | 2.23e-01 | 0.0596 |
51548 | SIRT6 | LZE21T | Human | Esophagus | ESCC | 1.34e-04 | 2.25e-01 | 0.0655 |
51548 | SIRT6 | LZE6T | Human | Esophagus | ESCC | 5.08e-05 | 2.52e-01 | 0.0845 |
51548 | SIRT6 | P1T-E | Human | Esophagus | ESCC | 5.05e-08 | 2.48e-01 | 0.0875 |
51548 | SIRT6 | P2T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.52e-01 | 0.1177 |
51548 | SIRT6 | P4T-E | Human | Esophagus | ESCC | 1.37e-18 | 3.52e-01 | 0.1323 |
51548 | SIRT6 | P5T-E | Human | Esophagus | ESCC | 1.13e-08 | 1.87e-01 | 0.1327 |
51548 | SIRT6 | P8T-E | Human | Esophagus | ESCC | 2.28e-35 | 5.94e-01 | 0.0889 |
51548 | SIRT6 | P9T-E | Human | Esophagus | ESCC | 8.65e-21 | 3.56e-01 | 0.1131 |
51548 | SIRT6 | P10T-E | Human | Esophagus | ESCC | 1.01e-32 | 4.74e-01 | 0.116 |
51548 | SIRT6 | P11T-E | Human | Esophagus | ESCC | 4.89e-11 | 3.99e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006056019 | Thyroid | ATC | developmental growth involved in morphogenesis | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:006053724 | Thyroid | ATC | muscle tissue development | 181/6293 | 403/18723 | 1.27e-06 | 1.62e-05 | 181 |
GO:003560114 | Thyroid | ATC | protein deacylation | 61/6293 | 112/18723 | 4.37e-06 | 4.79e-05 | 61 |
GO:000647614 | Thyroid | ATC | protein deacetylation | 56/6293 | 101/18723 | 5.15e-06 | 5.57e-05 | 56 |
GO:000176317 | Thyroid | ATC | morphogenesis of a branching structure | 96/6293 | 196/18723 | 5.68e-06 | 6.04e-05 | 96 |
GO:000628211 | Thyroid | ATC | regulation of DNA repair | 68/6293 | 130/18723 | 8.19e-06 | 8.27e-05 | 68 |
GO:001657512 | Thyroid | ATC | histone deacetylation | 47/6293 | 82/18723 | 8.75e-06 | 8.81e-05 | 47 |
GO:009873213 | Thyroid | ATC | macromolecule deacylation | 61/6293 | 116/18723 | 1.89e-05 | 1.72e-04 | 61 |
GO:001470622 | Thyroid | ATC | striated muscle tissue development | 168/6293 | 384/18723 | 1.91e-05 | 1.73e-04 | 168 |
GO:006113815 | Thyroid | ATC | morphogenesis of a branching epithelium | 88/6293 | 182/18723 | 2.55e-05 | 2.20e-04 | 88 |
GO:003220016 | Thyroid | ATC | telomere organization | 76/6293 | 159/18723 | 1.40e-04 | 9.75e-04 | 76 |
GO:00030075 | Thyroid | ATC | heart morphogenesis | 110/6293 | 246/18723 | 1.76e-04 | 1.20e-03 | 110 |
GO:200077911 | Thyroid | ATC | regulation of double-strand break repair | 45/6293 | 85/18723 | 1.83e-04 | 1.24e-03 | 45 |
GO:00487545 | Thyroid | ATC | branching morphogenesis of an epithelial tube | 71/6293 | 151/18723 | 4.18e-04 | 2.50e-03 | 71 |
GO:000751716 | Thyroid | ATC | muscle organ development | 139/6293 | 327/18723 | 4.45e-04 | 2.64e-03 | 139 |
GO:000630212 | Thyroid | ATC | double-strand break repair | 110/6293 | 251/18723 | 4.48e-04 | 2.65e-03 | 110 |
GO:010610621 | Thyroid | ATC | cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:012016121 | Thyroid | ATC | regulation of cold-induced thermogenesis | 68/6293 | 144/18723 | 4.70e-04 | 2.76e-03 | 68 |
GO:004576621 | Thyroid | ATC | positive regulation of angiogenesis | 82/6293 | 181/18723 | 6.79e-04 | 3.83e-03 | 82 |
GO:190401821 | Thyroid | ATC | positive regulation of vasculature development | 82/6293 | 181/18723 | 6.79e-04 | 3.83e-03 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa052302 | Colorectum | SER | Central carbon metabolism in cancer | 25/1580 | 70/8465 | 5.43e-04 | 4.51e-03 | 3.27e-03 | 25 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa052303 | Colorectum | SER | Central carbon metabolism in cancer | 25/1580 | 70/8465 | 5.43e-04 | 4.51e-03 | 3.27e-03 | 25 |
hsa04714211 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0523018 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa04714310 | Esophagus | ESCC | Thermogenesis | 163/4205 | 232/8465 | 9.22e-11 | 1.14e-09 | 5.86e-10 | 163 |
hsa0523019 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa0471430 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa0523016 | Oral cavity | OSCC | Central carbon metabolism in cancer | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
hsa04714113 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa0523017 | Oral cavity | OSCC | Central carbon metabolism in cancer | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIRT6 | SNV | Missense_Mutation | rs540970217 | c.583C>T | p.Arg195Trp | p.R195W | Q8N6T7 | protein_coding | deleterious(0) | benign(0.344) | TCGA-BH-A203-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SIRT6 | deletion | Frame_Shift_Del | novel | c.193delN | p.Arg65GlyfsTer95 | p.R65Gfs*95 | Q8N6T7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SIRT6 | deletion | Frame_Shift_Del | c.671delN | p.Asn224ThrfsTer39 | p.N224Tfs*39 | Q8N6T7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
SIRT6 | SNV | Missense_Mutation | c.787N>C | p.Thr263Pro | p.T263P | Q8N6T7 | protein_coding | tolerated(0.09) | benign(0.046) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
SIRT6 | SNV | Missense_Mutation | c.956N>T | p.Pro319Leu | p.P319L | Q8N6T7 | protein_coding | deleterious(0) | benign(0.133) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SIRT6 | SNV | Missense_Mutation | c.806N>A | p.Leu269Gln | p.L269Q | Q8N6T7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SIRT6 | SNV | Missense_Mutation | c.94N>T | p.Arg32Trp | p.R32W | Q8N6T7 | protein_coding | deleterious(0.02) | possibly_damaging(0.466) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIRT6 | SNV | Missense_Mutation | novel | c.908N>A | p.Ser303Tyr | p.S303Y | Q8N6T7 | protein_coding | tolerated(0.05) | benign(0.085) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIRT6 | SNV | Missense_Mutation | novel | c.1055N>T | p.Ala352Val | p.A352V | Q8N6T7 | protein_coding | tolerated_low_confidence(0.33) | benign(0) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIRT6 | SNV | Missense_Mutation | novel | c.653N>G | p.Gln218Arg | p.Q218R | Q8N6T7 | protein_coding | deleterious(0) | benign(0.327) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51548 | SIRT6 | TRANSCRIPTION FACTOR, ENZYME | inhibitor | 252827474 | ||
51548 | SIRT6 | TRANSCRIPTION FACTOR, ENZYME | allosteric modulator | 381118833 |
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