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Gene: PDHB |
Gene summary for PDHB |
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Gene information | Species | Human | Gene symbol | PDHB | Gene ID | 5162 |
Gene name | pyruvate dehydrogenase E1 subunit beta | |
Gene Alias | PDHBD | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P11177 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5162 | PDHB | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.41e-04 | 7.03e-02 | 0.0155 |
5162 | PDHB | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.25e-08 | 3.81e-01 | -0.0811 |
5162 | PDHB | HTA11_78_2000001011 | Human | Colorectum | AD | 2.53e-09 | 2.77e-01 | -0.1088 |
5162 | PDHB | HTA11_347_2000001011 | Human | Colorectum | AD | 4.81e-15 | 3.41e-01 | -0.1954 |
5162 | PDHB | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.26e-12 | 3.44e-01 | -0.059 |
5162 | PDHB | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.20e-04 | 3.56e-01 | -0.1706 |
5162 | PDHB | HTA11_546_2000001011 | Human | Colorectum | AD | 2.85e-03 | 1.37e-01 | -0.0842 |
5162 | PDHB | HTA11_866_3004761011 | Human | Colorectum | AD | 3.84e-06 | 2.11e-01 | 0.096 |
5162 | PDHB | HTA11_6801_2000001011 | Human | Colorectum | SER | 5.10e-03 | 3.61e-01 | 0.0171 |
5162 | PDHB | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.86e-03 | 1.29e-01 | 0.0674 |
5162 | PDHB | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.83e-08 | 3.83e-01 | 0.294 |
5162 | PDHB | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.37e-06 | 7.79e-01 | 0.3487 |
5162 | PDHB | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.29e-06 | 2.41e-01 | 0.281 |
5162 | PDHB | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.22e-08 | 3.52e-01 | 0.3859 |
5162 | PDHB | LZE4T | Human | Esophagus | ESCC | 2.46e-13 | 2.51e-01 | 0.0811 |
5162 | PDHB | LZE8T | Human | Esophagus | ESCC | 1.99e-05 | 8.24e-02 | 0.067 |
5162 | PDHB | LZE20T | Human | Esophagus | ESCC | 3.77e-02 | -5.29e-02 | 0.0662 |
5162 | PDHB | LZE22T | Human | Esophagus | ESCC | 1.13e-04 | 1.36e-01 | 0.068 |
5162 | PDHB | LZE24T | Human | Esophagus | ESCC | 4.27e-17 | 3.40e-01 | 0.0596 |
5162 | PDHB | LZE6T | Human | Esophagus | ESCC | 4.24e-04 | 6.32e-02 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000915028 | Thyroid | PTC | purine ribonucleotide metabolic process | 165/5968 | 368/18723 | 1.03e-07 | 2.05e-06 | 165 |
GO:007252127 | Thyroid | PTC | purine-containing compound metabolic process | 182/5968 | 416/18723 | 1.92e-07 | 3.51e-06 | 182 |
GO:000925927 | Thyroid | PTC | ribonucleotide metabolic process | 170/5968 | 385/18723 | 2.32e-07 | 4.08e-06 | 170 |
GO:000616327 | Thyroid | PTC | purine nucleotide metabolic process | 170/5968 | 396/18723 | 2.02e-06 | 2.75e-05 | 170 |
GO:000675325 | Thyroid | PTC | nucleoside phosphate metabolic process | 205/5968 | 497/18723 | 5.24e-06 | 6.35e-05 | 205 |
GO:000911725 | Thyroid | PTC | nucleotide metabolic process | 202/5968 | 489/18723 | 5.46e-06 | 6.60e-05 | 202 |
GO:001931810 | Thyroid | PTC | hexose metabolic process | 108/5968 | 237/18723 | 6.42e-06 | 7.65e-05 | 108 |
GO:000599614 | Thyroid | PTC | monosaccharide metabolic process | 115/5968 | 257/18723 | 9.36e-06 | 1.05e-04 | 115 |
GO:00060999 | Thyroid | PTC | tricarboxylic acid cycle | 21/5968 | 30/18723 | 2.04e-05 | 2.06e-04 | 21 |
GO:000600615 | Thyroid | PTC | glucose metabolic process | 90/5968 | 196/18723 | 2.54e-05 | 2.50e-04 | 90 |
GO:000915224 | Thyroid | PTC | purine ribonucleotide biosynthetic process | 78/5968 | 169/18723 | 6.88e-05 | 6.01e-04 | 78 |
GO:004639024 | Thyroid | PTC | ribose phosphate biosynthetic process | 85/5968 | 190/18723 | 1.30e-04 | 1.03e-03 | 85 |
GO:000926024 | Thyroid | PTC | ribonucleotide biosynthetic process | 81/5968 | 182/18723 | 2.27e-04 | 1.65e-03 | 81 |
GO:000609020 | Thyroid | PTC | pyruvate metabolic process | 51/5968 | 106/18723 | 3.47e-04 | 2.39e-03 | 51 |
GO:007252219 | Thyroid | PTC | purine-containing compound biosynthetic process | 86/5968 | 200/18723 | 5.85e-04 | 3.72e-03 | 86 |
GO:000616419 | Thyroid | PTC | purine nucleotide biosynthetic process | 81/5968 | 191/18723 | 1.35e-03 | 7.65e-03 | 81 |
GO:00442726 | Thyroid | PTC | sulfur compound biosynthetic process | 63/5968 | 148/18723 | 3.91e-03 | 1.87e-02 | 63 |
GO:000906033 | Thyroid | ATC | aerobic respiration | 126/6293 | 189/18723 | 1.21e-20 | 2.02e-18 | 126 |
GO:000609134 | Thyroid | ATC | generation of precursor metabolites and energy | 256/6293 | 490/18723 | 6.55e-18 | 7.69e-16 | 256 |
GO:004533333 | Thyroid | ATC | cellular respiration | 140/6293 | 230/18723 | 1.76e-17 | 1.89e-15 | 140 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00020 | Colorectum | AD | Citrate cycle (TCA cycle) | 20/2092 | 30/8465 | 1.43e-06 | 1.77e-05 | 1.13e-05 | 20 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa000201 | Colorectum | AD | Citrate cycle (TCA cycle) | 20/2092 | 30/8465 | 1.43e-06 | 1.77e-05 | 1.13e-05 | 20 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa006202 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000202 | Colorectum | SER | Citrate cycle (TCA cycle) | 16/1580 | 30/8465 | 2.06e-05 | 2.74e-04 | 1.99e-04 | 16 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDHB | SNV | Missense_Mutation | novel | c.947N>C | p.Asn316Thr | p.N316T | P11177 | protein_coding | deleterious(0.01) | benign(0.259) | TCGA-E2-A15A-06 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
PDHB | SNV | Missense_Mutation | c.985G>A | p.Asp329Asn | p.D329N | P11177 | protein_coding | deleterious(0.01) | probably_damaging(0.942) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PDHB | SNV | Missense_Mutation | novel | c.445N>A | p.Gly149Ser | p.G149S | P11177 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PDHB | SNV | Missense_Mutation | novel | c.959N>T | p.Ala320Val | p.A320V | P11177 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDHB | SNV | Missense_Mutation | c.157N>A | p.Val53Ile | p.V53I | P11177 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PDHB | SNV | Missense_Mutation | novel | c.787N>C | p.Cys263Arg | p.C263R | P11177 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PDHB | SNV | Missense_Mutation | c.794N>C | p.Val265Ala | p.V265A | P11177 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDHB | SNV | Missense_Mutation | novel | c.839N>C | p.Glu280Ala | p.E280A | P11177 | protein_coding | tolerated(0.33) | benign(0.019) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDHB | SNV | Missense_Mutation | novel | c.970N>T | p.Arg324Cys | p.R324C | P11177 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDHB | SNV | Missense_Mutation | novel | c.345N>A | p.Phe115Leu | p.F115L | P11177 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5162 | PDHB | ENZYME | CPI-613 | |||
5162 | PDHB | ENZYME | DEXLIPOTAM |
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