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Gene: NME4 |
Gene summary for NME4 |
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Gene information | Species | Human | Gene symbol | NME4 | Gene ID | 4833 |
Gene name | NME/NM23 nucleoside diphosphate kinase 4 | |
Gene Alias | NDPK-D | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087WVT9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4833 | NME4 | GSM4909291 | Human | Breast | IDC | 1.15e-16 | 6.27e-01 | 0.1753 |
4833 | NME4 | GSM4909293 | Human | Breast | IDC | 1.00e-40 | 7.62e-01 | 0.1581 |
4833 | NME4 | GSM4909296 | Human | Breast | IDC | 1.21e-22 | 4.49e-01 | 0.1524 |
4833 | NME4 | GSM4909297 | Human | Breast | IDC | 4.42e-11 | -1.69e-01 | 0.1517 |
4833 | NME4 | GSM4909298 | Human | Breast | IDC | 1.37e-08 | 4.07e-01 | 0.1551 |
4833 | NME4 | GSM4909301 | Human | Breast | IDC | 8.16e-12 | 4.15e-01 | 0.1577 |
4833 | NME4 | GSM4909304 | Human | Breast | IDC | 9.06e-06 | 3.91e-01 | 0.1636 |
4833 | NME4 | GSM4909306 | Human | Breast | IDC | 1.33e-27 | 6.44e-01 | 0.1564 |
4833 | NME4 | GSM4909311 | Human | Breast | IDC | 3.00e-24 | -9.24e-02 | 0.1534 |
4833 | NME4 | GSM4909312 | Human | Breast | IDC | 1.80e-10 | 1.58e-01 | 0.1552 |
4833 | NME4 | GSM4909313 | Human | Breast | IDC | 1.29e-04 | 1.21e-01 | 0.0391 |
4833 | NME4 | GSM4909315 | Human | Breast | IDC | 3.43e-06 | 4.12e-01 | 0.21 |
4833 | NME4 | GSM4909316 | Human | Breast | IDC | 1.72e-17 | 7.07e-01 | 0.21 |
4833 | NME4 | GSM4909319 | Human | Breast | IDC | 8.45e-43 | 1.61e-01 | 0.1563 |
4833 | NME4 | GSM4909320 | Human | Breast | IDC | 4.72e-08 | 2.15e-01 | 0.1575 |
4833 | NME4 | GSM4909321 | Human | Breast | IDC | 2.04e-20 | 2.52e-01 | 0.1559 |
4833 | NME4 | M2 | Human | Breast | IDC | 5.54e-13 | 6.44e-01 | 0.21 |
4833 | NME4 | NCCBC14 | Human | Breast | DCIS | 5.53e-09 | 1.14e-01 | 0.2021 |
4833 | NME4 | NCCBC5 | Human | Breast | DCIS | 3.42e-11 | -4.02e-03 | 0.2046 |
4833 | NME4 | P1 | Human | Breast | IDC | 1.20e-13 | -1.99e-01 | 0.1527 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000914510 | Prostate | BPH | purine nucleoside triphosphate biosynthetic process | 31/3107 | 69/18723 | 3.22e-08 | 9.18e-07 | 31 |
GO:000919910 | Prostate | BPH | ribonucleoside triphosphate metabolic process | 36/3107 | 89/18723 | 7.31e-08 | 1.88e-06 | 36 |
GO:000920610 | Prostate | BPH | purine ribonucleoside triphosphate biosynthetic process | 30/3107 | 68/18723 | 8.85e-08 | 2.18e-06 | 30 |
GO:000914117 | Prostate | BPH | nucleoside triphosphate metabolic process | 40/3107 | 112/18723 | 7.34e-07 | 1.39e-05 | 40 |
GO:000914210 | Prostate | BPH | nucleoside triphosphate biosynthetic process | 33/3107 | 85/18723 | 7.76e-07 | 1.45e-05 | 33 |
GO:000920110 | Prostate | BPH | ribonucleoside triphosphate biosynthetic process | 30/3107 | 74/18723 | 8.28e-07 | 1.54e-05 | 30 |
GO:000913215 | Prostate | BPH | nucleoside diphosphate metabolic process | 42/3107 | 124/18723 | 1.97e-06 | 3.27e-05 | 42 |
GO:000915217 | Prostate | BPH | purine ribonucleotide biosynthetic process | 52/3107 | 169/18723 | 3.46e-06 | 5.42e-05 | 52 |
GO:004693915 | Prostate | BPH | nucleotide phosphorylation | 35/3107 | 101/18723 | 7.69e-06 | 1.09e-04 | 35 |
GO:000911717 | Prostate | BPH | nucleotide metabolic process | 118/3107 | 489/18723 | 9.68e-06 | 1.35e-04 | 118 |
GO:000926010 | Prostate | BPH | ribonucleotide biosynthetic process | 53/3107 | 182/18723 | 1.63e-05 | 2.05e-04 | 53 |
GO:000675316 | Prostate | BPH | nucleoside phosphate metabolic process | 118/3107 | 497/18723 | 2.13e-05 | 2.58e-04 | 118 |
GO:004639010 | Prostate | BPH | ribose phosphate biosynthetic process | 54/3107 | 190/18723 | 2.90e-05 | 3.34e-04 | 54 |
GO:000616515 | Prostate | BPH | nucleoside diphosphate phosphorylation | 33/3107 | 99/18723 | 3.43e-05 | 3.82e-04 | 33 |
GO:00725229 | Prostate | BPH | purine-containing compound biosynthetic process | 55/3107 | 200/18723 | 6.64e-05 | 6.59e-04 | 55 |
GO:00061649 | Prostate | BPH | purine nucleotide biosynthetic process | 52/3107 | 191/18723 | 1.37e-04 | 1.22e-03 | 52 |
GO:0046039 | Prostate | BPH | GTP metabolic process | 11/3107 | 25/18723 | 1.18e-03 | 7.29e-03 | 11 |
GO:00091657 | Prostate | BPH | nucleotide biosynthetic process | 60/3107 | 254/18723 | 2.34e-03 | 1.28e-02 | 60 |
GO:19012937 | Prostate | BPH | nucleoside phosphate biosynthetic process | 60/3107 | 256/18723 | 2.83e-03 | 1.49e-02 | 60 |
GO:0046051 | Prostate | BPH | UTP metabolic process | 6/3107 | 12/18723 | 7.73e-03 | 3.39e-02 | 6 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00240 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa00983 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa002401 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa009831 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NME4 | SNV | Missense_Mutation | rs200178276 | c.427G>A | p.Val143Ile | p.V143I | O00746 | protein_coding | tolerated(1) | benign(0) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NME4 | SNV | Missense_Mutation | novel | c.247G>A | p.Glu83Lys | p.E83K | O00746 | protein_coding | tolerated(0.29) | benign(0.086) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NME4 | SNV | Missense_Mutation | novel | c.559N>A | p.Ala187Thr | p.A187T | O00746 | protein_coding | deleterious_low_confidence(0) | benign(0.014) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NME4 | SNV | Missense_Mutation | novel | c.187N>G | p.Arg63Gly | p.R63G | O00746 | protein_coding | deleterious(0.01) | possibly_damaging(0.501) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NME4 | SNV | Missense_Mutation | rs571220712 | c.454G>A | p.Ala152Thr | p.A152T | O00746 | protein_coding | deleterious(0.02) | benign(0.314) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
NME4 | SNV | Missense_Mutation | rs778308477 | c.506G>T | p.Ser169Ile | p.S169I | O00746 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-66-2778-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
NME4 | SNV | Missense_Mutation | rs145944648 | c.382N>A | p.Asp128Asn | p.D128N | O00746 | protein_coding | tolerated(1) | benign(0.055) | TCGA-CN-A63T-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
NME4 | SNV | Missense_Mutation | novel | c.458N>A | p.Ser153Asn | p.S153N | O00746 | protein_coding | deleterious(0) | possibly_damaging(0.851) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NME4 | deletion | Frame_Shift_Del | rs770464890 | c.471delN | p.Ala159ProfsTer15 | p.A159Pfs*15 | O00746 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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