Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001056341 | Stomach | SIM | negative regulation of phosphorus metabolic process | 31/708 | 442/18723 | 7.56e-04 | 1.06e-02 | 31 |
GO:003367341 | Stomach | SIM | negative regulation of kinase activity | 19/708 | 237/18723 | 1.74e-03 | 1.99e-02 | 19 |
GO:000640311 | Stomach | SIM | RNA localization | 16/708 | 201/18723 | 4.15e-03 | 3.72e-02 | 16 |
GO:000193331 | Stomach | SIM | negative regulation of protein phosphorylation | 23/708 | 342/18723 | 5.72e-03 | 4.67e-02 | 23 |
GO:006109911 | Stomach | SIM | negative regulation of protein tyrosine kinase activity | 5/708 | 31/18723 | 5.72e-03 | 4.67e-02 | 5 |
GO:0006403112 | Thyroid | PTC | RNA localization | 130/5968 | 201/18723 | 9.23e-22 | 1.94e-19 | 130 |
GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
GO:0051236110 | Thyroid | PTC | establishment of RNA localization | 100/5968 | 166/18723 | 4.26e-14 | 2.58e-12 | 100 |
GO:0050657110 | Thyroid | PTC | nucleic acid transport | 98/5968 | 163/18723 | 9.08e-14 | 4.90e-12 | 98 |
GO:0050658110 | Thyroid | PTC | RNA transport | 98/5968 | 163/18723 | 9.08e-14 | 4.90e-12 | 98 |
GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
GO:0042326113 | Thyroid | PTC | negative regulation of phosphorylation | 189/5968 | 385/18723 | 1.00e-12 | 4.64e-11 | 189 |
GO:0015931110 | Thyroid | PTC | nucleobase-containing compound transport | 120/5968 | 222/18723 | 5.45e-12 | 2.35e-10 | 120 |
GO:005102817 | Thyroid | PTC | mRNA transport | 78/5968 | 130/18723 | 3.44e-11 | 1.26e-09 | 78 |
GO:0051348113 | Thyroid | PTC | negative regulation of transferase activity | 137/5968 | 268/18723 | 3.78e-11 | 1.36e-09 | 137 |
GO:0006469111 | Thyroid | PTC | negative regulation of protein kinase activity | 107/5968 | 212/18723 | 1.24e-08 | 2.96e-07 | 107 |
GO:0033673111 | Thyroid | PTC | negative regulation of kinase activity | 115/5968 | 237/18723 | 5.98e-08 | 1.26e-06 | 115 |
GO:004677716 | Thyroid | PTC | protein autophosphorylation | 110/5968 | 227/18723 | 1.25e-07 | 2.44e-06 | 110 |
GO:003812720 | Thyroid | PTC | ERBB signaling pathway | 66/5968 | 121/18723 | 1.97e-07 | 3.54e-06 | 66 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MVP | SNV | Missense_Mutation | | c.510G>C | p.Gln170His | p.Q170H | Q14764 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MVP | SNV | Missense_Mutation | | c.1234G>A | p.Glu412Lys | p.E412K | Q14764 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MVP | insertion | Frame_Shift_Ins | novel | c.2374_2375insAAGGCCTTTTGCAATGGCTATTCCTGCTGCCCAGAAAGCT | p.Val792GlufsTer38 | p.V792Efs*38 | Q14764 | protein_coding | | | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
MVP | insertion | Frame_Shift_Ins | novel | c.874_875insA | p.Gly292GlufsTer55 | p.G292Efs*55 | Q14764 | protein_coding | | | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
MVP | insertion | In_Frame_Ins | novel | c.875_876insCTCTTCCTTTGAGCCCCAGTTTCAGTT | p.Gly292_Lys293insSerSerPheGluProGlnPheGlnPhe | p.G292_K293insSSFEPQFQF | Q14764 | protein_coding | | | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
MVP | insertion | Frame_Shift_Ins | novel | c.2596_2597insAGGTGAGAGTTGGGGAAGGTGTGTTGGTTTCAGGA | p.Pro866GlnfsTer43 | p.P866Qfs*43 | Q14764 | protein_coding | | | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
MVP | insertion | Frame_Shift_Ins | rs778534743 | c.1744dupG | p.Ala582GlyfsTer9 | p.A582Gfs*9 | Q14764 | protein_coding | | | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD |
MVP | SNV | Missense_Mutation | novel | c.2012C>T | p.Ala671Val | p.A671V | Q14764 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MVP | SNV | Missense_Mutation | novel | c.10N>A | p.Glu4Lys | p.E4K | Q14764 | protein_coding | tolerated(0.15) | benign(0.08) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MVP | SNV | Missense_Mutation | | c.2641N>G | p.Gln881Glu | p.Q881E | Q14764 | protein_coding | tolerated_low_confidence(0.21) | benign(0) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |